Aptamer 学术简报 — neurodegeneration — 2026-06-15

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 4 篇命中（aptamer 池 231 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [10.8] A label-free electrochemical aptasensor enables ultrasensitive and specific detection of neurofilament light.

Plasma neurofilament light chain (NfL) has been identified as a promising early-stage Alzheimer's disease (AD) biomarker, reflecting neuroaxonal degeneration at preclinical stages. However, its extremely low concentration in blood presents a major analytical challenge. Although single-molecule array (Simoa) assays provide exceptional sensitivity...

#2 [9.6] Circular RNA in human brain: Systematic review of synaptic functions and disease associations.

Circular RNAs (circRNAs) are covalently closed, non-canonical transcripts, highly enriched in the mammalian brain and especially synaptic compartments. Generated via back-splicing of precursor mRNAs, their intrinsic stability and spatiotemporally regulated expression enable the modulating function for synaptic physiology through multiple mechani...

#3 [5.7] Circular RNA aptamers act as superb sub-stoichiometric chaperones to prevent cytosolic TDP-43 condensation

Pathological protein misfolding and aggregation underlie many devastating human diseases, yet strategies to selectively neutralize aggregation-prone protein states without perturbing their normal functions remain limited. Here we identify loosely structured circular RNA (cRNA) aptamers, circT3 and its minimized 116-nt variant circT3-M3, as super...

#4 [5.3] Multidimensional successively targeted glucose-aptamer nano-system to achieve "Point-Surface" early intervention of Alzheimer's disease.

Difficulties such as low blood-brain barrier (BBB) permeability, insufficient accumulation of lesions and late treatment stage lead to difficulties in the treatment of Alzheimer's disease (AD). In this paper, a successively targeted polydopamine nano-system (Apt@PDA-Glu) was prepared for the first two difficulties, and the high transmittance of ...

Methodology