Aptamer 学术简报 — neurodegeneration — 2026-06-05

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 10 篇命中（aptamer 池 234 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [12.9] Circular RNA in human brain: Systematic review of synaptic functions and disease associations.

Circular RNAs (circRNAs) are covalently closed, non-canonical transcripts, highly enriched in the mammalian brain and especially synaptic compartments. Generated via back-splicing of precursor mRNAs, their intrinsic stability and spatiotemporally regulated expression enable the modulating function for synaptic physiology through multiple mechani...

#2 [11.8] Screening molecular recognition element-based SWCNT optical sensors for the inflammatory cytokine TNF-α.

TNF-α (Tumor Necrosis Factor) is a proinflammatory cytokine that amplifies inflammatory response and promotes leukocyte recruitment. TNF-α is primarily produced by activated macrophages, among others, in response to infection, inflammation, or tissue damage. Given its central role in normal and abnormal immune responses, it is the target of seve...

#3 [10.7] Label-Free Electrochemiluminescence Detection of Urinary AD7c-NTP Using Structurally Optimized Iridium(III) Complexes on Boron-Doped Diamond Electrodes.

Evaluation of Alzheimer's disease-associated neuronal thread protein (AD7c-NTP) in urine holds significant potential as a noninvasive and accessible biomarker for the early diagnosis of Alzheimer's disease (AD). In this study, a novel label-free and ultrasensitive electrochemiluminescence (ECL) sensor for detection of AD7c-NTP was designed based...

#4 [9.7] Multicompartment Drug Monitoring Reveals Paired Brain-Liver Kinetics and Selective Central Nervous System Barrier Permeability in Rats.

Characterizing drug distribution to target organs is of central importance to drug discovery, especially for compounds intended to reach the central nervous system (CNS). However, the current benchmark standard measurements, based on tissue homogenate, provide limited spatial and temporal resolution. Here, we use real-time electrochemical aptame...

#5 [9.0] Circular RNA aptamers act as superb sub-stoichiometric chaperones to prevent cytosolic TDP-43 condensation

Pathological protein misfolding and aggregation underlie many devastating human diseases, yet strategies to selectively neutralize aggregation-prone protein states without perturbing their normal functions remain limited. Here we identify loosely structured circular RNA (cRNA) aptamers, circT3 and its minimized 116-nt variant circT3-M3, as super...

#6 [7.7] Xerogel-Engineered Graphitic Carbon Nitride Interfaces Enable Aptamer-Based Detection of Salivary Lactoferrin for Noninvasive Diagnosis of Alzheimer's Disease.

Alzheimer's disease (AD), the primary cause of dementia, is a progressive neurodegenerative disorder that requires early diagnosis using noninvasive biosensing strategies. Salivary lactoferrin has consequently emerged as a compelling early-stage AD biomarker, as its dysregulated expression reflects underlying neuroinflammatory mechanisms associa...

#7 [7.0] Synthesis of Phenyl 2-Acetamidoselenogalactoside Mimetics and Interaction with Amyloid β1–42

Background/Objectives: Protein–carbohydrate interactions are implicated in amyloid aggregation pathways associated with Alzheimer’s disease (AD). Designing glycomimetics that modulate amyloid assembly represents a promising strategy. In addition, the interaction of Aβ1–42 oligomers (Aβo) with prion protein (PrPC) activates Fyn kinase and leads t...

#8 [6.3] Decoding the Spatiotemporal Logic of Cellular Senescence through Multimodal Exosomal miRNA Integration.

We have developed a multimodal biosensing platform for the in situ monitoring of exosomal RNAs without cell lysis. This system employs a cascade of aptamer recognition, rolling circle amplification (RCA), and G-quadruplex/hemin signal transduction. Electrochemical and colorimetric outputs are seamlessly integrated using an inverse-variance-weigh...

#9 [5.3] Harnessing TfR1 for Cross-Species Systemic Delivery of siRNAs to Deep Brain Regions Using Single-Domain Antibodies

Despite their therapeutic potential across a wide range of central nervous system (CNS) disorders, nucleic acid-based therapeutics are limited by inefficient delivery to deep brain regions at clinically viable doses. Transferrin receptor 1 (TfR1) has emerged as an attractive target for receptor-mediated transcytosis across the blood-brain barrie...

Methodology