Aptamer 学术简报 — neurodegeneration — 2026-05-31

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 neurodegeneration：近 14 天 12 篇命中（aptamer 池 212 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [12.3] Label-Free Electrochemiluminescence Detection of Urinary AD7c-NTP Using Structurally Optimized Iridium(III) Complexes on Boron-Doped Diamond Electrodes.

Evaluation of Alzheimer's disease-associated neuronal thread protein (AD7c-NTP) in urine holds significant potential as a noninvasive and accessible biomarker for the early diagnosis of Alzheimer's disease (AD). In this study, a novel label-free and ultrasensitive electrochemiluminescence (ECL) sensor for detection of AD7c-NTP was designed based...

#2 [11.3] Multicompartment Drug Monitoring Reveals Paired Brain-Liver Kinetics and Selective Central Nervous System Barrier Permeability in Rats.

Characterizing drug distribution to target organs is of central importance to drug discovery, especially for compounds intended to reach the central nervous system (CNS). However, the current benchmark standard measurements, based on tissue homogenate, provide limited spatial and temporal resolution. Here, we use real-time electrochemical aptame...

#3 [11.3] Aptamer-Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN-STAT3 Complex and Enables Liquid Biopsy Detection.

Colorectal cancer (CRC) poses a significant global health challenge, highlighting the need for better diagnostic tools and molecular targets. Compared to traditional antibodies, aptamers, which are single-stranded oligonucleotides with high affinity and low immunogenicity, offer an ideal platform for discovering novel biomarkers. Based on this a...

#4 [10.0] Determination of Small-Sized α-Synuclein Oligomers Using Solid-State Nanopore Assisted with Circular Single-Stranded DNA Frame.

Misfolded α-synuclein (αS) is significantly associated with the onset and progression of Parkinson's disease (PD), a critical neurodegenerative disorder. In particular, small-sized aggregated αS oligomers are more cytotoxic than mature amyloid-type aggregates and are essential inducers of PD. Solid-state nanopores, functioning as single-molecule...

#5 [9.3] Xerogel-Engineered Graphitic Carbon Nitride Interfaces Enable Aptamer-Based Detection of Salivary Lactoferrin for Noninvasive Diagnosis of Alzheimer's Disease.

Alzheimer's disease (AD), the primary cause of dementia, is a progressive neurodegenerative disorder that requires early diagnosis using noninvasive biosensing strategies. Salivary lactoferrin has consequently emerged as a compelling early-stage AD biomarker, as its dysregulated expression reflects underlying neuroinflammatory mechanisms associa...

#6 [8.7] Synthesis of Phenyl 2-Acetamidoselenogalactoside Mimetics and Interaction with Amyloid β1–42

Background/Objectives: Protein–carbohydrate interactions are implicated in amyloid aggregation pathways associated with Alzheimer’s disease (AD). Designing glycomimetics that modulate amyloid assembly represents a promising strategy. In addition, the interaction of Aβ1–42 oligomers (Aβo) with prion protein (PrPC) activates Fyn kinase and leads t...

#7 [8.0] Decoding the Spatiotemporal Logic of Cellular Senescence through Multimodal Exosomal miRNA Integration.

We have developed a multimodal biosensing platform for the in situ monitoring of exosomal RNAs without cell lysis. This system employs a cascade of aptamer recognition, rolling circle amplification (RCA), and G-quadruplex/hemin signal transduction. Electrochemical and colorimetric outputs are seamlessly integrated using an inverse-variance-weigh...

#8 [7.0] Harnessing TfR1 for Cross-Species Systemic Delivery of siRNAs to Deep Brain Regions Using Single-Domain Antibodies

Despite their therapeutic potential across a wide range of central nervous system (CNS) disorders, nucleic acid-based therapeutics are limited by inefficient delivery to deep brain regions at clinically viable doses. Transferrin receptor 1 (TfR1) has emerged as an attractive target for receptor-mediated transcytosis across the blood-brain barrie...

#9 [6.0] Biomarker-targeted functionalized magnetic nanoparticles: synthesis and aptamer conjugation optimization toward Alzheimer's disease biosensing.

Magnetic-plasmonic hybrid nanoparticles are gaining prominence in biomedical diagnostics due to their dual functionality, combining magnetic manipulation and signal enhancement. A major challenge remains the reproducible synthesis of core-shell nanostructures with controlled size, composition, and stability. In this work, we present a robust two...

#10 [6.0] Aptamer-based technologies for theranostics of central nervous system disorders

Abstract Aptamers are short single-stranded DNA or RNA ligands that fold into defined three-dimensional structures and bind targets with antibody-like affinity and specificity, yet retain key advantages for central nervous system (CNS) applications including chemical synthesis, low immunogenicity, thermal stability, and facile modular engineerin...

Methodology