Aptamer 学术简报 — infectious_disease — 2026-09-25

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 11 篇命中（aptamer 池 124 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.1] Live imaging and interactome analysis of Zika and chikungunya viral RNAs via dual-action aptamer tag

Arthropod-borne, positive-sense RNA viruses encompass many human pathogens posing significant health threats worldwide. Understanding intracellular dynamics and host-factor interactions of the viral genome is essential for devising effective antiviral strategies. Here, we engineer dual-labeled Zika and chikungunya viruses incorporating a Mango-I...

#2 [13.2] A Sprayable Multifunctional Film Based on EGFR-Targeting DNA Nanoactivators for Burn Wound Healing.

Burn treatment remains a tough clinical hurdle, as traditional epidermal growth factor (EGF) treatments suffer from rapid proteolytic degradation and poor skin permeation. Herein, a sprayable, multifunctional film (STAR) based on EGFR-targeting DNA nanoactivators is reported for efficient burn wound healing. The STAR platform combines tannic aci...

#3 [11.7] RPA-CRISPR/Cas12a and Aptamer-Based Electrochemical Biosensing Duplex Platform for On-Site Monitoring of Antimicrobial Resistance in Water

Abstract Monitoring antimicrobial resistance (AMR) in aquatic systems is essential for tracking resistance mechanisms and identifying microbial sources. Here, we present a dual-module electrochemical sensing platform that integrates a gold-electrode-based RPA–CRISPR/Cas12a biosensor for detecting antibiotic resistance genes (ARGs) with a paper-b...

#4 [11.6] Streptavidin-Displaying E. coli Scaffolds Enable Target-Mediated Gold Nanoparticle Assembly for Colorimetric Biosensing

Enhancing the visual detection sensitivity of point-of-care (POC) optical sensors without resorting to complex, multistep chemical or enzymatic signal amplification remains a major challenge in sensor nanotechnology. Here, we present a multifunctional bio-nanostructured hybrid platform that integrates engineered Escherichia coli cellular scaffol...

#5 [11.1] Atomically dispersed ruthenium on magnetic layered double hydroxide nanozyme for a multi-mode aptasensor enabling highly sensitive kanamycin detection.

Kanamycin residues in food pose health risks due to their ototoxicity, nephrotoxicity, and antimicrobial resistance promotion. This work reports a multi-mode aptasensor combining atomically dispersed ruthenium-doped magnetic layered double hydroxide (RuSA/MLDH) with exonuclease I-assisted amplification. RuSA/MLDH exhibits DNA-enhanced peroxidase...

#6 [9.3] High-fidelity genotyping and therapeutic oligonucleotides analysis by liquid-phase ion trap coupled with mass spectrometry

Rapid and accurate nucleic acid analysis is essential for disease diagnostics and drug development, yet persistent metal cation interference severely limits mass spectrometry’s effectiveness. We developed a liquid-phase ion trap (LPIT) system that utilizes strong electric fields to simultaneously dissociate metal contaminants and enrich purified...

#7 [8.3] Disease Biomarker Detection Using Fluorescence Polarization Assays: Principles and Clinical Applications

Modern clinical diagnostics require highly sensitive, rapid, and technologically simple methods for quantitatively determining biomarkers directly at the patient’s bedside. Fluorescence polarization (FP) meets these criteria, as it enables the homogeneous recording of an analytical signal based on changes in the rotational diffusion of a fluores...

#8 [7.0] Signatures of the neutralizing dengue virus-reactive memory B cell repertoire identified by multiplexed envelope dimer probes

Sequential dengue virus (DENV) infection is thought to induce long-lived protection against dengue. However, little is known about the specificity, phenotype, and repertoire of the enduring B cell response due to limitations in high-throughput methods. We used stabilized DENV envelope (E) dimers as probes for in-depth memory B cell repertoire ch...

#9 [6.7] Antiviral Activity Does Not Establish Packaging Inhibition: An Evidence Audit of HIV-1 Packaging-Signal RNA Decoys

Background. Selective encapsidation of HIV-1 genomic RNA (gRNA) is essential for infectivity, and RNA constructs derived from the packaging signal (Ψ) have been explored as antivirals for over three decades. Antiviral activity and packaging-specific inhibition are, however, distinct claims, and the literature has not consistently separated them....

#10 [6.7] Antiviral Activity Does Not Establish Packaging Inhibition: An Evidence Audit of HIV-1 Packaging-Signal RNA Decoys

Background. Selective encapsidation of HIV-1 genomic RNA (gRNA) is essential for infectivity, and RNA constructs derived from the packaging signal (Ψ) have been explored as antivirals for over three decades. Antiviral activity and packaging-specific inhibition are, however, distinct claims, and the literature has not consistently separated them....

Methodology