Aptamer 学术简报 — infectious_disease — 2026-09-21

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 11 篇命中（aptamer 池 137 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.5] A Sprayable Multifunctional Film Based on EGFR-Targeting DNA Nanoactivators for Burn Wound Healing.

Burn treatment remains a tough clinical hurdle, as traditional epidermal growth factor (EGF) treatments suffer from rapid proteolytic degradation and poor skin permeation. Herein, a sprayable, multifunctional film (STAR) based on EGFR-targeting DNA nanoactivators is reported for efficient burn wound healing. The STAR platform combines tannic aci...

#2 [13.0] RPA-CRISPR/Cas12a and Aptamer-Based Electrochemical Biosensing Duplex Platform for On-Site Monitoring of Antimicrobial Resistance in Water

Abstract Monitoring antimicrobial resistance (AMR) in aquatic systems is essential for tracking resistance mechanisms and identifying microbial sources. Here, we present a dual-module electrochemical sensing platform that integrates a gold-electrode-based RPA–CRISPR/Cas12a biosensor for detecting antibiotic resistance genes (ARGs) with a paper-b...

#3 [12.5] Atomically dispersed ruthenium on magnetic layered double hydroxide nanozyme for a multi-mode aptasensor enabling highly sensitive kanamycin detection.

Kanamycin residues in food pose health risks due to their ototoxicity, nephrotoxicity, and antimicrobial resistance promotion. This work reports a multi-mode aptasensor combining atomically dispersed ruthenium-doped magnetic layered double hydroxide (RuSA/MLDH) with exonuclease I-assisted amplification. RuSA/MLDH exhibits DNA-enhanced peroxidase...

#4 [10.6] Harmonizing amplification and cleavage kinetics through crRNA scaffold mutation enables robust one-pot CRISPR–Cas12 diagnostics

CRISPR-based diagnostics (CRISPR-Dx) integrated with isothermal nucleic acid amplification have emerged as a promising strategy for point-of-care molecular testing. Their practical deployment, however, remains constrained by workflow-related limitations. Conventional two-step formats are laborious and highly susceptible to aerosol contamination ...

#5 [8.9] An interface-engineered signal-on electrochemical aptasensor for H5N2 avian influenza virus detection.

Outbreaks of avian influenza virus (AIV) cause substantial economic losses in the poultry industry, highlighting the need for sensitive, reliable and field-adaptable detection platforms. In this study, we report a signal-on electrochemical aptasensor for avian influenza virus H5N2(K08-404) by translating a previously reported J3/JH4 cognate apta...

#6 [8.3] Signatures of the neutralizing dengue virus-reactive memory B cell repertoire identified by multiplexed envelope dimer probes

Sequential dengue virus (DENV) infection is thought to induce long-lived protection against dengue. However, little is known about the specificity, phenotype, and repertoire of the enduring B cell response due to limitations in high-throughput methods. We used stabilized DENV envelope (E) dimers as probes for in-depth memory B cell repertoire ch...

#7 [8.0] Antiviral Activity Does Not Establish Packaging Inhibition: An Evidence Audit of HIV-1 Packaging-Signal RNA Decoys

Background. Selective encapsidation of HIV-1 genomic RNA (gRNA) is essential for infectivity, and RNA constructs derived from the packaging signal (Ψ) have been explored as antivirals for over three decades. Antiviral activity and packaging-specific inhibition are, however, distinct claims, and the literature has not consistently separated them....

#8 [8.0] Antiviral Activity Does Not Establish Packaging Inhibition: An Evidence Audit of HIV-1 Packaging-Signal RNA Decoys

Background. Selective encapsidation of HIV-1 genomic RNA (gRNA) is essential for infectivity, and RNA constructs derived from the packaging signal (Ψ) have been explored as antivirals for over three decades. Antiviral activity and packaging-specific inhibition are, however, distinct claims, and the literature has not consistently separated them....

#9 [6.0] Nanomaterials in Optical Biosensors for Nucleic Acid Detection

This review presents a comprehensive overview of modern nanomaterial-based biosensors for nucleic acid detection, with a particular focus on optical, colorimetric, and surface-enhanced Raman spectroscopy (SERS) methods that operate without enzymes or external labels. The fundamental principle underlying many of these platforms is the specific hy...

#10 [5.3] Multifunctional CMC–Nanographene Oxide Hydrogels Couple Fluorophore-Free Cancer Cell Imaging with Antioxidant and Antimicrobial Activity

Background: The development of sustainable biomaterials that combine imaging capability with complementary biological functions without relying on incorporated drugs or exogenous fluorophores represents an attractive strategy for multifunctional biomedical platforms. Methods: Here, carboxymethyl cellulose (CMC) hydrogels reinforced with nanograp...

Methodology