Aptamer 学术简报 — infectious_disease — 2026-09-17

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 10 篇命中（aptamer 池 137 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.9] A Sprayable Multifunctional Film Based on EGFR-Targeting DNA Nanoactivators for Burn Wound Healing.

Burn treatment remains a tough clinical hurdle, as traditional epidermal growth factor (EGF) treatments suffer from rapid proteolytic degradation and poor skin permeation. Herein, a sprayable, multifunctional film (STAR) based on EGFR-targeting DNA nanoactivators is reported for efficient burn wound healing. The STAR platform combines tannic aci...

#2 [11.9] Harmonizing amplification and cleavage kinetics through crRNA scaffold mutation enables robust one-pot CRISPR–Cas12 diagnostics

CRISPR-based diagnostics (CRISPR-Dx) integrated with isothermal nucleic acid amplification have emerged as a promising strategy for point-of-care molecular testing. Their practical deployment, however, remains constrained by workflow-related limitations. Conventional two-step formats are laborious and highly susceptible to aerosol contamination ...

#3 [10.2] An interface-engineered signal-on electrochemical aptasensor for H5N2 avian influenza virus detection.

Outbreaks of avian influenza virus (AIV) cause substantial economic losses in the poultry industry, highlighting the need for sensitive, reliable and field-adaptable detection platforms. In this study, we report a signal-on electrochemical aptasensor for avian influenza virus H5N2(K08-404) by translating a previously reported J3/JH4 cognate apta...

#4 [9.3] Antiviral Activity Does Not Establish Packaging Inhibition: An Evidence Audit of HIV-1 Packaging-Signal RNA Decoys

Background. Selective encapsidation of HIV-1 genomic RNA (gRNA) is essential for infectivity, and RNA constructs derived from the packaging signal (Ψ) have been explored as antivirals for over three decades. Antiviral activity and packaging-specific inhibition are, however, distinct claims, and the literature has not consistently separated them....

#5 [9.3] Antiviral Activity Does Not Establish Packaging Inhibition: An Evidence Audit of HIV-1 Packaging-Signal RNA Decoys

Background. Selective encapsidation of HIV-1 genomic RNA (gRNA) is essential for infectivity, and RNA constructs derived from the packaging signal (Ψ) have been explored as antivirals for over three decades. Antiviral activity and packaging-specific inhibition are, however, distinct claims, and the literature has not consistently separated them....

#6 [7.3] Nanomaterials in Optical Biosensors for Nucleic Acid Detection

This review presents a comprehensive overview of modern nanomaterial-based biosensors for nucleic acid detection, with a particular focus on optical, colorimetric, and surface-enhanced Raman spectroscopy (SERS) methods that operate without enzymes or external labels. The fundamental principle underlying many of these platforms is the specific hy...

#7 [6.7] Multifunctional CMC–Nanographene Oxide Hydrogels Couple Fluorophore-Free Cancer Cell Imaging with Antioxidant and Antimicrobial Activity

Background: The development of sustainable biomaterials that combine imaging capability with complementary biological functions without relying on incorporated drugs or exogenous fluorophores represents an attractive strategy for multifunctional biomedical platforms. Methods: Here, carboxymethyl cellulose (CMC) hydrogels reinforced with nanograp...

#8 [6.0] DNA aptamers to interfere with HasA, the hemophore of the heme assimilation system in Pseudomonas aeruginosa, as a potential antimicrobial strategy

Pseudomonas aeruginosa relies on heme acquisition to sustain growth and virulence in the iron-limited environment of the host, particularly in the acidic airways of patients with cystic fibrosis where antibiotic efficacy is markedly reduced. The Has heme assimilation system is initiated by the secreted hemophore HasA, which binds extracellular h...

#9 [5.3] Identification of a SARS-CoV-2 Spike RNA-Cleaving DNAzyme and Optimization of Its AS1411 Chimera

Sequence-specific cleavage of viral RNA by deoxyribozymes offers a direct approach for suppressing viral gene expression, although limited cellular accessibility remains a major barrier to their functional application. In this study, a panel of eight deoxyribozymes representing different catalytic motifs and target regions was designed against S...

Methodology