Aptamer 学术简报 — infectious_disease — 2026-08-24

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 12 篇命中（aptamer 池 205 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [12.5] High-ThroughputOn-Chip Screening Enables Rapid Adaptationof DNA Aptamers to SARS-CoV-2 Evolution

Abstract Rapid pathogen evolution threatens public health by eroding the effectiveness of vaccines, therapeutics, and diagnostic tools. Although spike-protein-targeting monoclonal antibodies (mAbs) were developed within 10–12 months of the initial outbreak to serve as key theranostic agents, their redesign has struggled to keep pace with viral e...

#2 [12.5] Chimeric ascorbic acid phosphate-releasing nucleotide probes for isothermal signal-amplified protein detection.

Protein detection is essential for disease diagnosis and biomarker analysis but often relies on antibodies and sophisticated instrumentation. Here, we report a signal-amplified protein detection strategy based on chimeric ascorbic acid-2-phosphate (AAP)-releasing nucleotide probes and strand displacement amplification (SDA). Two tetraphosphate n...

#3 [11.8] Surface-confined CRISPR-Cas12a biosensor with metal-enhanced fluorescence for rapid and ultrasensitive detection of SARS-CoV-2 nucleocapsid protein.

CRISPR-Cas12a integrated with nanomaterials has formulated powerful biosensors for viral protein detection, addressing the urgent need for point-of-care diagnostics. However, existing platforms are hindered by either multi-step separation procedures or insufficient signal amplification, limiting their sensitivity and practicality. Here, we repor...

#4 [11.1] Single-Particle Tracking and Positional Phenotyping Reveal Variant-Specific Early Checkpoints in SARS-CoV-2 Cell Entry.

Bulk assays of SARS-CoV-2 entry obscure individual virions and conflate binding with internalization. We developed a quantitative single-particle imaging assay that classifies fluorescent virus-like particles (VLPs) as surface, crossing, or internal on HEK293T-ACE2 cells, separating binding from internalization. Comparing G614 and Omicron BA.5 S...

#5 [9.3] Inhibitor-RegulatedCas12a Activation Enables HighlySensitive and One-Pot Detection of Drug-Resistant Genes in River Water

Abstract Monitoring environmental drug-resistance genes (DRGs) plays a pivotal role in preventing the transmission of antimicrobial resistance, thereby reducing public health risks. In this study, a one-pot recombinase polymerase amplification (RPA)/clustered regularly interspaced short palindromic repeat (CRISPR) assay was developed for monitor...

#6 [8.3] High-Sensitivity Magnetic Particle Spectroscopy Platform for Precise, Specific, and Rapid Detection of Infectious Disease and Cancer-Related Biomarkers.

Accurate biosensing using magnetic particle spectroscopy (MPS) depends on the interplay between biomolecular binding and the fidelity of the measurement system. MPS enables wash-free, label-free biosensing by monitoring Brownian relaxation-induced changes in magnetic nanoparticle (MNP) dynamics. However, its practical performance is often limite...

#7 [7.7] A label-free and highly sensitive fluorescence aptasensor for enrofloxacin detection based on G-triplex-mediated signal amplification.

Enrofloxacin (ENR), a third-generation fluoroquinolone veterinary antibiotic, is widely used in aquaculture and animal husbandry for bacterial infection control due to its broad-spectrum antimicrobial activity, potent bactericidal efficacy, and cost-effectiveness. However, its excessive and non-standard use has caused widespread residues in anim...

#8 [6.3] Threomer Inhibition of S1−ACE2 Binding

Abstract The interaction between the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S1) and human ACE2 receptor is essential for viral entry into host epithelial cells and a key target for drug discovery. Here, we describe the evolution of a threomer, a base-modified version of threose nucleic acid (TNA), that binds to the S1 pro...

#9 [6.0] Surface-Enhanced Raman Spectroscopy for Viral Diagnostics: Principles, Strategies, Clinical Challenges, and Future Directions.

Viral outbreaks such as SARS-CoV, MERS-CoV, and COVID-19 underscore the urgent need for rapid, sensitive, and scalable diagnostic technologies. Current standard methods, including nucleic acid amplification tests and immunoassays, offer complementary strengths but face limitations in cost, turnaround time, and early-stage detection. Surface-enha...

Methodology