Aptamer 学术简报 — infectious_disease — 2026-08-12

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 10 篇命中（aptamer 池 198 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.3] FOCUS: A Dual-Mismatch crRNA Strategy Unlocks High-Fidelity One-Step SNV Detection with Cas12a

CRISPR/Cas12a has emerged as a powerful tool for nucleic acid detection; however, its clinical utility is severely hampered by intrinsic limitations in single-nucleotide variant (SNV) discrimination, reliance on pre-processed single-stranded DNA (ssDNA) templates, and cumbersome multi-step workflows. Here, we report a novel molecular design prin...

#2 [13.3] Inhibitor-RegulatedCas12a Activation Enables HighlySensitive and One-Pot Detection of Drug-Resistant Genes in River Water

Abstract Monitoring environmental drug-resistance genes (DRGs) plays a pivotal role in preventing the transmission of antimicrobial resistance, thereby reducing public health risks. In this study, a one-pot recombinase polymerase amplification (RPA)/clustered regularly interspaced short palindromic repeat (CRISPR) assay was developed for monitor...

#3 [10.9] Strategies for biofilm disruption: Mechanisms, polymeric networks, mixed infections, and emerging biomaterials.

Biofilms represent the predominant microbial lifestyle in clinical and environmental settings, where the extracellular polymeric substance (EPS) matrix provides structural integrity, metabolic cooperation, and pronounced antimicrobial tolerance. This matrix forms a dynamic macromolecular network of polysaccharides, proteins, extracellular DNA (e...

#4 [10.6] Synergistic magnetic nano-chemotherapy overcomes chemoresistance in 3D breast cancer models.

Monodispersed highly magnetic iron oxide nanocubes and nanospheres with magnetization (78.72 emu/gcubic and 72.08 emu/gsphere with an average size of 17.45 ± 5.13 nm for spherical (IONPs) and with edge lengths ranging from 20.85 ± 6.60 nm for nanocubes (IONCs) have been successfully synthesized and functionalized with methoxy-polyethylene glycol...

#5 [10.4] Single-Particle Tracking and Positional Phenotyping Reveal Variant-Specific Early Checkpoints in SARS-CoV-2 Cell Entry

Abstract Bulk assays of SARS-CoV-2 entry obscure individual virions and conflate binding with internalization. We developed a quantitative single-particle imaging assay that classifies fluorescent virus-like particles (VLPs) as surface, crossing, or internal on HEK293T-ACE2 cells, separating binding from internalization. Comparing G614 and Omicr...

#6 [10.0] Amplification-free Electrochemiluminescence Biosensors based on Peptide-templated gold Nanocluster and CRISPR-Cas12a for Mycobacterium Tuberculosis IS6110 Detection

#7 [9.7] A Rationally Designed Split Lettuce Aptamer Based on Large-Scale Mutational Analysis

Abstract Split-aptamer biosensors offer exceptionally low background by assembling only in the presence of a target analyte; however, their performance is frequently limited by the lack of robust design rules for selecting effective split sites. Existing approaches largely rely on heuristic, structure-based assumptions that are poorly validated ...

#8 [7.0] ACE2-PNA conjugates exploit viral endocytosis for targeted intracellular delivery and exhibit dual antiviral efficacy against SARS-CoV-2

The COVID-19 pandemic and its protracted consequences underscore the urgent need for more effective antiviral strategies. Current antiviral strategies face a persistent challenge achieving sufficient viral suppression while minimizing off-target toxicity, particularly against such highly mutable viruses. Here, we describe a Receptor-Drug Conjuga...

#9 [5.7] Surface-EnhancedRaman Spectroscopy for Viral Diagnostics:Principles, Strategies, Clinical Challenges, and Future Directions

Abstract Viral outbreaks such as SARS-CoV, MERS-CoV, and COVID-19 underscore the urgent need for rapid, sensitive, and scalable diagnostic technologies. Current standard methods, including nucleic acid amplification tests and immunoassays, offer complementary strengths but face limitations in cost, turnaround time, and early-stage detection. Sur...

Methodology