Aptamer 学术简报 — infectious_disease — 2026-07-28

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 6 篇命中（aptamer 池 192 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [11.5] A novel nanosensor for in situ detection of EV-miR-107 enables noninvasive tuberculosis diagnosis and treatment monitoring.

Tuberculosis (TB) remains a leading cause of infectious death globally, creating an urgent need for rapid and non-invasive diagnostics. Extracellular vesicles (EVs) have emerged as promising carriers of disease-specific microRNAs with biomarker potential. This study identifies EV-miR-107 as a candidate host-response biomarker for TB, showing sig...

#2 [10.2] The Intrinsic Disordered N-Terminus of Nucleocapsid Protein of SARS-CoV-2 Is Critical in DNA Aptamer Binding

SARS-CoV-2 nucleocapsid protein (N protein) binds nucleic acids and packages viral RNA. DNA aptamers that specifically bind the N protein have been used in antigen-based COVID-19 detection and have potential clinical applications for preventing SARS-CoV-2 infection. However, the complex structures of the N protein with DNA aptamers and the mecha...

#3 [9.2] In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies.

Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins, and efficiently optimizing their binding affinities, remain challenging. Here, we present CAAMO (Computer-Aided Aptamer Modeling and Optimization), which integrates in silico aptamer design with experimental vali...

#4 [9.2] In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

Abstract Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins and efficiently optimizing their binding affinities remain challenging. Here, we present CAAMO (Computer-Aided Aptamer Modeling and Optimization), which integrates in silico aptamer design with experiment...

#5 [8.3] Enhanced label-free SARS-CoV-2 biomarker detection using a gold-functionalized Ag–ZnO–Fe₂O₃ multilayer surface plasmon resonance biosensor

#6 [5.3] Rationally designed split Lettuce aptamer based on large scale mutational analysis

Split aptamer biosensors offer exceptionally low background by assembling only in the presence of a target analyte; however, their performance is frequently limited by the lack of robust design rules for selecting effective split sites. Existing approaches largely rely on heuristic, structure-based assumptions that are poorly validated and often...

Methodology