Aptamer 学术简报 — infectious_disease — 2026-07-21

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 11 篇命中（aptamer 池 178 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.8] A novel nanosensor for in situ detection of EV-miR-107 enables noninvasive tuberculosis diagnosis and treatment monitoring.

Tuberculosis (TB) remains a leading cause of infectious death globally, creating an urgent need for rapid and non-invasive diagnostics. Extracellular vesicles (EVs) have emerged as promising carriers of disease-specific microRNAs with biomarker potential. This study identifies EV-miR-107 as a candidate host-response biomarker for TB, showing sig...

#2 [11.6] In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies.

Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins, and efficiently optimizing their binding affinities, remain challenging. Here, we present CAAMO (Computer-Aided Aptamer Modeling and Optimization), which integrates in silico aptamer design with experimental vali...

#3 [11.6] In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

Abstract Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins and efficiently optimizing their binding affinities remain challenging. Here, we present CAAMO (Computer-Aided Aptamer Modeling and Optimization), which integrates in silico aptamer design with experiment...

#4 [11.0] Recent Progress in Artificial Intelligence in Biosensor Development: From Bioprobe Design to Fabrication and Signal Analysis

The coronavirus disease 2019 (COVID-19) pandemic highlighted the need for rapid, accurate, and point-of-care diagnostic technologies, accelerating interest in biosensors as next-generation analytical platforms. However, biosensor performance is governed by a connected sequence of processes, including bioprobe–target recognition, sensor fabricati...

#5 [10.0] Plasmonic response of aptamer-functionalized gold nanoparticles via target-induced aggregation for oxytetracycline detection.

The widespread use of oxytetracycline (OTC) in sericulture to control bacterial infections and improve silkworm productivity has raised significant concerns regarding the emergence of antimicrobial resistance and antibiotic residue accumulation in seri-products, highlighting the need for reliable monitoring strategies. In this work, we report a ...

#6 [7.7] Rationally designed split Lettuce aptamer based on large scale mutational analysis

Split aptamer biosensors offer exceptionally low background by assembling only in the presence of a target analyte; however, their performance is frequently limited by the lack of robust design rules for selecting effective split sites. Existing approaches largely rely on heuristic, structure-based assumptions that are poorly validated and often...

#7 [6.3] Pushing the Limits of Protein Detection... Ultrasensitive Aptasensor Based on a Quantum-Biological Interface

Published in the journal Frontiers in Photonics, this study designs an aptamer-based platform to detect the clinically relevant dengue NS1 protein, completely reinterpreting it from the perspective of a quantum-biological interface. Moving beyond classical approaches, the research demonstrates that electrochemical capacitance systems can be trea...

#8 [6.3] Pushing the Limits of Protein Detection... Ultrasensitive Aptasensor Based on a Quantum-Biological Interface

Published in the journal Frontiers in Photonics, this study designs an aptamer-based platform to detect the clinically relevant dengue NS1 protein, completely reinterpreting it from the perspective of a quantum-biological interface. Moving beyond classical approaches, the research demonstrates that electrochemical capacitance systems can be trea...

#9 [5.7] SELEX to Clinic: Evolution, Innovations and Applications of Aptamers in Precision Medicine

Aptamers are short, single-stranded DNA or RNA oligonucleotides selected in vitro via SELEX (Systematic Evolution of Ligands by Exponential Enrichment) that fold into defined 3-D structures and bind cognate targets with antibody-like affinity yet superior versatility. Thirty-five years after their simultaneous disclosure by Ellington & Szostak a...

#10 [5.7] SELEX to Clinic: Evolution, Innovations and Applications of Aptamers in Precision Medicine

Aptamers are short, single-stranded DNA or RNA oligonucleotides selected in vitro via SELEX (Systematic Evolution of Ligands by Exponential Enrichment) that fold into defined 3-D structures and bind cognate targets with antibody-like affinity yet superior versatility. Thirty-five years after their simultaneous disclosure by Ellington & Szostak a...

Methodology