Aptamer 学术简报 — infectious_disease — 2026-06-24

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 7 篇命中（aptamer 池 168 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.1] Functionalized carbon nanotube-assisted dual-mode CRISPR/Cas12a detection of hepatitis C virus via catalytic assembly circuit-driven Y-shaped dsDNA activators.

Hepatitis C virus (HCV) is a major etiological agent of liver diseases and remains a serious global health threat. Herein, we report a dual-modal HCV biosensing platform for ultrasensitive HCV RNA detection by integrating near-infrared fluorescence and colorimetric readouts. In this system, the presence of HCV RNA initiates a catalytic assembly ...

#2 [10.3] Amino Acid-Programmed Biomineralization for Radical-Proximal Enzyme-MOF Interfaces in Electrochemiluminescent Influenza Hemagglutinin Sensing.

Electrochemiluminescent (ECL) biosensing is fundamentally limited by inefficient coupling between catalytic radical generation and luminophore excitation. Here, we report an amino acid-programmed biomineralization strategy for constructing radical-proximal enzyme-MOF interfaces under mild aqueous conditions. Serine reconfigures zirconium precurs...

#3 [9.7] Aptamer-based biosensing strategies for influenza virus detection: a systematic and critical review of electrochemical and optical platforms.

Influenza virus remains a major global health challenge due to its genetic variability and frequent emergence of novel strains. Subtyping is determined by the diverse arrangements of hemagglutinin (HA) and neuraminidase (NA) glycoproteins, with HA frequently serving as the molecular target for diagnostic assays. Conventional detection methods, h...

#4 [8.3] Geometric Deep Learning Reveals Ligandable and Cryptic RNA Binding Small Molecule Pockets (SMARTPocket)

RNAs are important therapeutic targets, however identifying ligandable small-molecule binding pockets remains a major barrier to RNA-targeted drug discovery. Here, SMARTPocket, an atomic-level geometric deep learning framework for predicting RNA-small molecule binding pockets directly from three-dimensional structure is introduced. SMARTPocket r...

#5 [7.0] An AutocatalyticMolecular Sensor Enables Rapid, Sensitive,and One-Pot Detection of Nucleic Acids

Circulating nucleic acids are emerging disease markers whose clinical applications are hindered by the lack of rapid, sensitive, convenient, and cost-effective detection assays. Inspired by the natural replication of virus, here, we developed a biomimetic one-step, one-pot, isothermal detection assay named RAPID to realize rapid and sensitive de...

#6 [5.3] Sennoside A and Ceftazidime Inhibit Nucleocapsid RNA Binding Across SARS-CoV-2, SARS-CoV, and MERS-CoV

SARS-CoV, MERS-CoV, and SARS-CoV-2 exemplify the persistent threat posed by coronaviruses, with their capacity for zoonotic spill over, rapid transmission, and high mortality, and thus underscores the urgent need for broad-spectrum antiviral strategies. The nucleocapsid (N) protein, essential for RNA binding, genome packaging, and viral replicat...

Methodology