Aptamer 学术简报 — infectious_disease — 2026-06-16

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 10 篇命中（aptamer 池 155 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [20.5] Aptamer modified NPA hollow nanozymes with intrinsic peroxidase-like activity for colorimetric sensing of H1N1.

A colorimetric sensor based on aptamer-functionalized nanozyme probes was successfully developed for the sensitive and specific detection of influenza A (H1N1) virus. In this study, trimetallic nickel-palladium-gold hollow nanozymes (NPA) with excellent peroxidase (POD)-like activity were used as catalytic probes. Compared to the horseradish per...

#2 [13.0] Amino Acid-Programmed Biomineralization for Radical-Proximal Enzyme-MOF Interfaces in Electrochemiluminescent Influenza Hemagglutinin Sensing.

Electrochemiluminescent (ECL) biosensing is fundamentally limited by inefficient coupling between catalytic radical generation and luminophore excitation. Here, we report an amino acid-programmed biomineralization strategy for constructing radical-proximal enzyme-MOF interfaces under mild aqueous conditions. Serine reconfigures zirconium precurs...

#3 [10.0] A Portable Dual-Mode Aptasensor for Rapid Detection of Influenza A Hemagglutinin.

We report a highly portable dual modality aptasensing platform for the detection of surface glycoprotein, hemagglutinin (HA), of the influenza A virus. The sensing device consists of a colorimetric detection component composed of a microfluidic paper-based analytical device (μPAD) having four analyte testing areas, as well as a flexible, miniatu...

#4 [8.0] Sennoside A and Ceftazidime Inhibit Nucleocapsid RNA Binding Across SARS-CoV-2, SARS-CoV, and MERS-CoV

SARS-CoV, MERS-CoV, and SARS-CoV-2 exemplify the persistent threat posed by coronaviruses, with their capacity for zoonotic spill over, rapid transmission, and high mortality, and thus underscores the urgent need for broad-spectrum antiviral strategies. The nucleocapsid (N) protein, essential for RNA binding, genome packaging, and viral replicat...

#5 [6.3] Synthesis and Evaluation of Aromatic Sulfonamide and Disulfonamide Derivatives as Dengue Virus NS3–NS5 Interaction Inhibitors

Emerging viral threats highlight the urgent need for antivirals targeting viral replication mechanisms. Based on previous research, we expanded a series of asymmetric benzene‐1,4‐disulfonamides. As these proved to be synthetically challenging and generally more toxic than expected, we optimized a hit structure by omitting one sulfonamide group. ...

#6 [6.3] A High-Sensitivity Colorimetric Dot-Blot Aptamer Assay Platform for SARS-CoV-2 Nucleocapsid Protein Detection in Resource-Limited Settings.

We developed a colorimetric dot-blot aptamer assay to address the urgent need for accessible, high-performance SARS-CoV-2 diagnostics in resource-limited settings. Our in-house 96-well dot-blot platform featuring optimized PVDF membrane fluidics and standardized clamping combines nucleocapsid protein (N)-specific monoclonal antibody capture with...

#7 [6.3] A High-SensitivityColorimetric Dot-Blot Aptamer AssayPlatform for SARS-CoV‑2 Nucleocapsid Protein Detection in Resource-LimitedSettings

We developed a colorimetric dot-blot aptamer assay to address the urgent need for accessible, high-performance SARS-CoV-2 diagnostics in resource-limited settings. Our in-house 96-well dot-blot platform featuring optimized PVDF membrane fluidics and standardized clamping combines nucleocapsid protein (N)-specific monoclonal antibody capture with...

#8 [5.7] Translating biosynthetic gene cluster architecture into biosensor design for microbial natural product discovery.

Antimicrobial resistance (AMR) is a growing global health crisis, with mortality already in the millions and projections of up to 10 million deaths annually by 2050. Traditional discovery strategies, such as one strain many compounds-based screening of large strain collections, have yielded most of our current antibiotics but are slow, resource-...

Methodology