Aptamer 学术简报 — infectious_disease — 2026-06-08

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 15 篇命中（aptamer 池 236 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.6] Aptamer modified NPA hollow nanozymes with intrinsic peroxidase-like activity for colorimetric sensing of H1N1.

A colorimetric sensor based on aptamer-functionalized nanozyme probes was successfully developed for the sensitive and specific detection of influenza A (H1N1) virus. In this study, trimetallic nickel-palladium-gold hollow nanozymes (NPA) with excellent peroxidase (POD)-like activity were used as catalytic probes. Compared to the horseradish per...

#2 [12.7] A Portable Dual-Mode Aptasensor for Rapid Detection of Influenza A Hemagglutinin.

We report a highly portable dual modality aptasensing platform for the detection of surface glycoprotein, hemagglutinin (HA), of the influenza A virus. The sensing device consists of a colorimetric detection component composed of a microfluidic paper-based analytical device (μPAD) having four analyte testing areas, as well as a flexible, miniatu...

#3 [9.4] A framework for the development and validation of an aptamer-based assay for pathogen detection using SARS-CoV-2 as a model.

The COVID-19 pandemic exposed major disparities in global diagnostic capacity, particularly in low- and middle-income countries (LMICs) where reliance on conventional assays and external technologies hindered rapid response. Aptamers offer a promising alternative; however, practical and experimentally validated frameworks that connect aptamer di...

#4 [9.0] Synthesis and Evaluation of Aromatic Sulfonamide and Disulfonamide Derivatives as Dengue Virus NS3–NS5 Interaction Inhibitors

Emerging viral threats highlight the urgent need for antivirals targeting viral replication mechanisms. Based on previous research, we expanded a series of asymmetric benzene‐1,4‐disulfonamides. As these proved to be synthetically challenging and generally more toxic than expected, we optimized a hit structure by omitting one sulfonamide group. ...

#5 [9.0] A High-Sensitivity Colorimetric Dot-Blot Aptamer Assay Platform for SARS-CoV-2 Nucleocapsid Protein Detection in Resource-Limited Settings.

We developed a colorimetric dot-blot aptamer assay to address the urgent need for accessible, high-performance SARS-CoV-2 diagnostics in resource-limited settings. Our in-house 96-well dot-blot platform featuring optimized PVDF membrane fluidics and standardized clamping combines nucleocapsid protein (N)-specific monoclonal antibody capture with...

#6 [8.7] Rapid detection of Mycobacterium tuberculosis based on aptamer modified surface-enhanced Raman scattering biosensors.

Tuberculosis (TB), a deadly infectious disease caused by Mycobacterium tuberculosis (Mtb), was the second leading cause of death from a single infectious agent after COVID-19 in 2022, killing nearly twice as many people as AIDS, and still affecting more than 10 million people every year. Traditional diagnostic methods have the problems of low se...

#7 [8.3] Translating biosynthetic gene cluster architecture into biosensor design for microbial natural product discovery.

Antimicrobial resistance (AMR) is a growing global health crisis, with mortality already in the millions and projections of up to 10 million deaths annually by 2050. Traditional discovery strategies, such as one strain many compounds-based screening of large strain collections, have yielded most of our current antibiotics but are slow, resource-...

#8 [7.7] Selective capture and digital counting of intact HIV pseudovirus using designer DNA nets, tethered motion, and photonic resonator interferometric scattering microscopy.

Rapid and quantitatively accurate detection of HIV (human immunodeficiency virus) viral load using a simple workflow, automated instrumentation, and real-time data processing with easily interpretable output is required for an approach to become practical for point-of-care environments. We recently demonstrated a form of interferometric scatteri...

#9 [5.7] Fluorescent Aptamers Go Viral: Tracking the Coseparation of a SARS-CoV-2 RNA Fragment with the Nucleocapsid Protein Using the Encoded Mango II Tag.

Fluorescent aptamers (FLAPs) are encodable RNA tags that light up upon binding to their cognate fluorogenic dyes, thereby facilitating RNA imaging. While single-molecule imaging remains challenging, RNA assembly into biocondensates can be tracked by using FLAP-based systems. This has been demonstrated for human RNA-protein condensates but not fo...

#10 [5.7] Hierarchical Functionalisation of UiO-66(Zr)-NH2 with Cysteine, PEG, and SARS-CoV-2 Spike RBD to Facilitate ACE2 Receptor Targeting in Model Cells

Hierarchical functionalisation of the UiO-66(Zr)-NH2 metal–organic framework with cysteine, poly(ethylene glycol) (PEG), and the SARS-CoV-2 spike receptor-binding domain (RBD) was developed to enable receptor-specific interaction with the angiotensin-converting enzyme 2 receptor (ACE2) in model cells. Post-synthetic modification using cysteine a...

Methodology