Aptamer 学术简报 — infectious_disease — 2026-06-01

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 13 篇命中（aptamer 池 248 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [11.7] A framework for the development and validation of an aptamer-based assay for pathogen detection using SARS-CoV-2 as a model.

The COVID-19 pandemic exposed major disparities in global diagnostic capacity, particularly in low- and middle-income countries (LMICs) where reliance on conventional assays and external technologies hindered rapid response. Aptamers offer a promising alternative; however, practical and experimentally validated frameworks that connect aptamer di...

#2 [11.0] Rapid detection of Mycobacterium tuberculosis based on aptamer modified surface-enhanced Raman scattering biosensors.

Tuberculosis (TB), a deadly infectious disease caused by Mycobacterium tuberculosis (Mtb), was the second leading cause of death from a single infectious agent after COVID-19 in 2022, killing nearly twice as many people as AIDS, and still affecting more than 10 million people every year. Traditional diagnostic methods have the problems of low se...

#3 [10.7] Scalable and sustainable manufacturing of functional DNA nanoassemblies via self-folding circular single-stranded DNA.

Functional DNA nanoassemblies (fDns) hold promise for biomedical and translational applications, but broader deployment is limited by manufacturing barriers that constrain scalability, reproducibility, and stability. Current biosynthetic approaches rely heavily on downstream enzymatic processing and purification, which dominate economic, operati...

#4 [10.0] Selective capture and digital counting of intact HIV pseudovirus using designer DNA nets, tethered motion, and photonic resonator interferometric scattering microscopy.

Rapid and quantitatively accurate detection of HIV (human immunodeficiency virus) viral load using a simple workflow, automated instrumentation, and real-time data processing with easily interpretable output is required for an approach to become practical for point-of-care environments. We recently demonstrated a form of interferometric scatteri...

#5 [8.0] Fluorescent Aptamers Go Viral: Tracking the Coseparation of a SARS-CoV-2 RNA Fragment with the Nucleocapsid Protein Using the Encoded Mango II Tag.

Fluorescent aptamers (FLAPs) are encodable RNA tags that light up upon binding to their cognate fluorogenic dyes, thereby facilitating RNA imaging. While single-molecule imaging remains challenging, RNA assembly into biocondensates can be tracked by using FLAP-based systems. This has been demonstrated for human RNA-protein condensates but not fo...

#6 [8.0] Hierarchical Functionalisation of UiO-66(Zr)-NH2 with Cysteine, PEG, and SARS-CoV-2 Spike RBD to Facilitate ACE2 Receptor Targeting in Model Cells

Hierarchical functionalisation of the UiO-66(Zr)-NH2 metal–organic framework with cysteine, poly(ethylene glycol) (PEG), and the SARS-CoV-2 spike receptor-binding domain (RBD) was developed to enable receptor-specific interaction with the angiotensin-converting enzyme 2 receptor (ACE2) in model cells. Post-synthetic modification using cysteine a...

#7 [7.0] Aptamer-conjugated nanoparticles: emerging nano-enabled platforms for rapid and sensitive detection of viral infections.

During the recent outbreak of SARS-CoV-2, the global healthcare system experienced firsthand the importance of accurate and rapid detection techniques in the containment of pandemic situations. Conventional viral detection techniques, although highly specific, often suffer from slow, labour-intensive workflows that limit their applicability for ...

#8 [6.3] Nanomaterial-nucleic acid probe synergy: accelerating rapid pathogen detection and antimicrobial susceptibility testing in bloodstream infections.

Bloodstream infections (BSIs) remain among the most lethal clinical syndromes, driven in large part by diagnostic delays that compel empiric, broad-spectrum antimicrobial therapy and expose patients to avoidable toxicity and resistance selection. Conventional blood culture-based workflows, although diagnostically definitive, are intrinsically sl...

Methodology