Aptamer 学术简报 — cancer — 2026-10-12

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 59 篇命中（aptamer 池 223 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [19.6] Synergistic MIP-aptamer dual-recognition on silver-decorated sulfur-doped graphene quantum dots (S-GQDs@Ag) nanohybrids for ultra-sensitive impedimetric carcinoembryonic antigen detection.

The clinical utility of Carcinoembryonic Antigen (CEA) as a cornerstone biomarker for oncological monitoring is frequently hindered by the limitations of traditional immunoassays, including high costs, specialized storage requirements, and complex procedural workflows. To address these challenges, we report the development of a high-performance ...

#2 [14.8] Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers

Abstract Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect cytotoxic T cells ...

#3 [13.1] Temperature-responsive PDDNFs@QDs integrating simplified isolation for efficient tumor-derived small extracellular vesicles analysis enables breast cancer diagnosis and subtyping.

Multiplexed small extracellular vesicles (sEVs) biomarker detection holds great promise for breast cancer diagnosis and subtyping; however, its clinical application is often hampered by the complex isolation and detection processes. Herein, we propose a temperature-responsive sensing platform (PDDNFs@QDs) utilizing poly(N-isopropylacrylamide) (P...

#4 [13.0] Bifunctional CuPt Nanoclusters and DSN-Mediated Target Recycling Enabled Dual-Mode OPECT/Colorimetric Biosensing for Ultrasensitive and Wide-Range Detection of miRNA-21

Abstract MicroRNA-21 (miRNA-21) is an important cancer biomarker that requires highly sensitive and reliable detection across a broad concentration range. Here, we report a dual-mode biosensing platform that integrates organic photoelectrochemical transistor (OPECT) amplification with nanozyme-assisted colorimetric transduction for ultrasensitiv...

#5 [13.0] Decoupled Signal Transduction via a Non-Copper Laccase Mimic for CRISPR-Based Electrochemical Detection of Hepatocellular Carcinoma

Abstract Laccase-mimicking nanozymes have been overwhelmingly copper-dependent, and largely confined to environmental contexts, with clinical translation remaining unrealized. Here, we depart from this paradigm by designing a non-copper nanozyme, Mn-Trp NR, assembled through manganese-tryptophan coordination. Spectroscopic and theoretical analys...

#6 [12.9] Acid-Activatable Rolling Circle Replication-Based Nucleic Acid Nano-Prodrug for Combined Gene Therapy of Pancreatic Cancer.

Nucleic acid-based gene therapeutics hold great potential for precisely treating pancreatic ductal adenocarcinoma (PDAC), yet their clinical translation remains challenged by the lack of efficient delivery platforms capable of simultaneously minimizing payload leakage, intrinsic toxicity, and immunogenicity. Herein, we report an acid-activatable...

#7 [12.7] Ultrasensitive Electrochemiluminescence Aptasensor With DNA Nanotetrahedron Amplification for Multilevel Detection of cTnI From Cells to Patients.

Accurate detection of myocardial injury (MI) biomarkers for assessing anticancer drug-induced cardiotoxicity has long been constrained by insufficient capture efficiency and limited assay sensitivity. To address this challenge, we developed an electrochemiluminescence (ECL) aptasensor for the detection of cardiac troponin I (cTnI) based on a two...

#8 [12.7] NIR-II-Accelerated 2D-on-2D Silicene/MOF Heterointerfaces Disrupt Tumor Redox Homeostasis for Targeted Ferroptosis

Abstract Catalytic ferroptosis therapy provides an attractive approach for tumor treatment, but its practical efficacy is often limited by insufficient reaction kinetics and the strong redox buffering capacity of the tumor microenvironment. Herein, we report an interface-engineered 2D-on-2D catalytic nanoplatform, SNs/FTC@Apt-P (SFTCP), construc...

#9 [12.3] Double-Lock Superpolymer TDN is Used for the Theranostics of HCC

Abstract Hepatocellular carcinoma (HCC) is difficult to diagnose early and treat effectively due to its heterogeneity and lack of highly specific biomarkers. Here, we develop a double-lock superpolymer tetrahedral DNA (TDN) integrated with small extracellular vesicles (SUPDIA) for HCC theranostics. The TDN incorporates an HSP70 aptamer and a miR...

#10 [11.6] A dual-factor-gated DNA nanomachine enables spatially controlled microRNA imaging with improved tumor specificity

Methodology