Aptamer 学术简报 — cancer — 2026-09-25

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 34 篇命中（aptamer 池 124 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.8] DNA Nanoassembly Modified Polydopamine@MnO(2) Nanoparticles: Enhancement of miRNA-21 Downregulation for Reversal of Breast Cancer Drug-Resistance.

Downregulating oncogenic microRNAs (miRNAs) is an attractive strategy for reversing drug resistance in cancer therapy. Compared to antisense, DNAzyme (Dz) possesses advantages such as recyclability and stability. However, it still suffers from insufficient stability and inadequate endogenous cofactors. Herein, by using miRNA-21 (miR-21) as targe...

#2 [13.7] Isolation and Purification-Free Digital Single-Small Extracellular Vesicle Biosensing with Scalable Plasmonic Arrays

Abstract Recent advances in plasmonic biosensing and imaging have enabled label-free analysis of single biological nanoparticles. We previously developed PlAsmonic NanOapeRture lAbel-free iMAging (PANORAMA) for isolation and purification-free, digital counting and precise localization of antibody captured, tetraspanin-positive small extracellula...

#3 [13.3] Cascade-Amplified Microfluidic Detection of Tumor Biomarkers via Metal-DNA Nanospheres Activating CRISPR-Cas12a Assay

Abstract The development of ultrasensitive protein detection platforms is pivotal for early cancer diagnosis, yet existing methods are often constrained by inefficient “protein-to-signal” conversion and complex instrumentation. While CRISPR-Cas-based biosensors offer higher sensitivity for nucleic acids, their application in protein analysis is ...

#4 [13.2] A Sprayable Multifunctional Film Based on EGFR-Targeting DNA Nanoactivators for Burn Wound Healing.

Burn treatment remains a tough clinical hurdle, as traditional epidermal growth factor (EGF) treatments suffer from rapid proteolytic degradation and poor skin permeation. Herein, a sprayable, multifunctional film (STAR) based on EGFR-targeting DNA nanoactivators is reported for efficient burn wound healing. The STAR platform combines tannic aci...

#5 [13.0] Leukemic Stem Cell-Targeted Liposomal Nanoimmunotherapy Reverses Immune Evasion and Inhibits Fusion Oncoprotein-Driven Acute Myeloid Leukemia by Silencing B-Cell Lymphoma 2.

Acute Myeloid Leukemia (AML) is a prevalent and aggressive hematologic cancer driven by leukemic stem cells and immune evasion. Among its subtypes, Mixed Lineage Leukemia-AF9 (MLL-AF9)- rearranged AML is exceptionally lethal, with B-cell lymphoma 2 (Bcl2), a key anti-apoptotic protein, supporting leukemic survival and immune dysfunction. Targeti...

#6 [12.6] A self-powered biosensing platform for U937 cell detection and the induction of mitochondrial aggregation.

An EBFC platform was developed for U937 cell detection via aptamer-triggered glucose oxidation. The generated electrons reduced cathode Fe3+, disrupting an alginate hydrogel to release mitochondrial-targeting nanoparticles. Intracellularly, ATP-induced DNA hybridization caused mitochondrial aggregation and ROS-mediated intervention, achieving cl...

#7 [12.6] A target-activated AS1411 aptamer probe for in vivo and ex vivo imaging of nucleolin-overexpressing triple-negative breast cancer

Background Fluorescence imaging of breast cancer is often limited by high background signals from conventional “always-on” probes. The nucleolin-targeting AS1411 aptamer provides a promising recognition element for tumors with elevated nucleolin expression, including triple-negative breast cancer (TNBC). This study aimed to develop a target-acti...

#8 [12.1] Thermosensitive NIR-II fluorescence nanotracer for targeted detection of sentinel lymph nodes

Current tracers for sentinel lymph node (SLN) biopsy in breast cancer suffer from limitations including poor accumulation, short retention times, and background staining interference at the surgical site. To address these shortcomings, we developed a dual-functional thermoresponsive nanotracer based on PbS quantum dots functionalized with poly(N...

#9 [11.7] High‐Performance Optical Fiber SPR Biosensor for Label‐Free Detection of miRNA‐588 Toward Osteosarcoma Diagnosis

ABSTRACT Osteosarcoma is a malignant bone tumor for which diagnosis is critical to patient prognosis. MicroRNA‐588 is downregulated in osteosarcoma, highlighting its potential as a diagnostic biomarker. However, its low abundance in body fluids makes sensitive detection difficult. This study presents a label‐free reflective optical fiber surface...

#10 [11.2] A tumor-targeting strategy based on covalent aptamer-carborane conjugates.

The development of tumor-targeting agents is of great significance for cancer therapy. Despite the promising potential of Boron Neutron Capture Therapy (BNCT), efficient and selective accumulation of boron-10 agents in cancer cells remains challenging. Conjugation of carborane with tumor-targeting ligands provides an alternative strategy for sel...

Methodology