Aptamer 学术简报 — cancer — 2026-09-18

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 41 篇命中（aptamer 池 137 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.5] A Sprayable Multifunctional Film Based on EGFR-Targeting DNA Nanoactivators for Burn Wound Healing.

Burn treatment remains a tough clinical hurdle, as traditional epidermal growth factor (EGF) treatments suffer from rapid proteolytic degradation and poor skin permeation. Herein, a sprayable, multifunctional film (STAR) based on EGFR-targeting DNA nanoactivators is reported for efficient burn wound healing. The STAR platform combines tannic aci...

#2 [14.5] Thermosensitive NIR-II fluorescence nanotracer for targeted detection of sentinel lymph nodes

Current tracers for sentinel lymph node (SLN) biopsy in breast cancer suffer from limitations including poor accumulation, short retention times, and background staining interference at the surgical site. To address these shortcomings, we developed a dual-functional thermoresponsive nanotracer based on PbS quantum dots functionalized with poly(N...

#3 [14.0] High‐Performance Optical Fiber SPR Biosensor for Label‐Free Detection of miRNA‐588 Toward Osteosarcoma Diagnosis

ABSTRACT Osteosarcoma is a malignant bone tumor for which diagnosis is critical to patient prognosis. MicroRNA‐588 is downregulated in osteosarcoma, highlighting its potential as a diagnostic biomarker. However, its low abundance in body fluids makes sensitive detection difficult. This study presents a label‐free reflective optical fiber surface...

#4 [13.0] Self-Assembled Aptamer-Derived PROTAC Enables Efficient Cellular Internalization for Intracellular Sclerostin Degradation and Triple-Negative Breast Cancer Therapy.

Comprising an aptamer for protein of interest (POI) recognition, a linker, and an E3 ligand, aptamer-derived PROTAC enables precise intracellular POI degradation via ubiquitin-proteasome system. Due to hydrophilic polyanionic backbone, their efficacy was fundamentally constrained by inefficient cellular internalization. Here, we engineered a sel...

#5 [12.5] Aptamer recognition driven cascaded biocomputation on surface of serum-derived small extracellular vesicles

Multiplexed profiling of small extracellular vesicle (sEV) surface proteins holds promise for cancer diagnosis and prognosis due to the improved accuracy resulted from probing multiple biomarkers, yet simultaneously identifying these biomarkers on sEVs and directly reporting the analytical results remains a significant challenge. Here, we develo...

#6 [12.3] Self-Enhancing Photodynamic / Immunotherapy via a MOF Nanoplatform for Combined STING Activation and Immune Checkpoint Blockade.

Combinational photodynamic and immune checkpoint blockade (PDT/ICB) therapy is a promising approach for oncotherapy. However, the tumor microenvironment (TME) poses multiple biological barriers that can critically undermine the treatment outcomes of PDT/ICB. To this end, a cascade-amplified photodynamic immunotherapy nanoplatform based on the co...

#7 [12.3] Stimuli-Responsive DNA Tetrahedral Lysosome-Targeting Chimeras for Enhanced HER2 Protein Degradation.

Overexpression and abnormal activation of membrane proteins promote malignant tumor cell proliferation, while traditional interventions are often limited by drug resistance caused by target mutations. Here, we designed a stimulus-responsive DNA tetrahedron lysosome-targeted chimera (tFNA-LYTAC) strategy for degrading embrane proteins. Two tetrah...

#8 [12.2] Beyond the Needle: Is Liquid Biopsy the Future of Veterinary Medicine?

The detection of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) is a minimally invasive approach for diagnosing and monitoring cancer. These liquid biopsy-based strategies enable the identification of primary or metastatic tumors and provide valuable information on tumor biology and treatment response. A variety of techniques a...

#9 [10.8] Identification of melanotransferrin (MFI2) as a membrane target and an MFI2-directed aptamer as a theranostic tool for pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis and limited targeted therapeutic options. Melanotransferrin (MFI2) is a membrane-anchored protein that we found to be significantly upregulated in PDAC tissues and cell lines. MFI2 knockdown markedly reduced cell proliferation, migration, invasion, and epithelial-mesenchy...

#10 [10.7] Aptamer-Functionalized DNA Frameworks as Targeted Drug Buffers for Concentration Regulation of Maytansine.

Traditional chemotherapy often suffers from nonspecific distribution and poor drug concentration control, leading to compromised therapeutic efficacy and adverse effects. Mertansine (DM1), a potent cytotoxic agent with poor selectivity, dose-limiting toxicity, and a narrow therapeutic window, demands targeted delivery and precise concentration r...

Methodology