Aptamer 学术简报 — cancer — 2026-09-16

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 44 篇命中（aptamer 池 146 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.7] Self-Assembled Aptamer-Derived PROTAC Enables Efficient Cellular Internalization for Intracellular Sclerostin Degradation and Triple-Negative Breast Cancer Therapy.

Comprising an aptamer for protein of interest (POI) recognition, a linker, and an E3 ligand, aptamer-derived PROTAC enables precise intracellular POI degradation via ubiquitin-proteasome system. Due to hydrophilic polyanionic backbone, their efficacy was fundamentally constrained by inefficient cellular internalization. Here, we engineered a sel...

#2 [13.3] AuPt bimetallic nanocatalyst-amplified luminol-dissolved oxygen electrochemiluminescence for interferon-γ immunosensing

Interferon-γ (IFN-γ) is a pivotal inflammatory cytokine whose abnormal expression is associated with autoimmune disorders, infectious diseases, and cancer. Herein, a signal-off electrochemiluminescence (ECL) immunosensor was developed by integrating catalytic signal amplification with oriented antibody immobilization. An amino-functionalized ver...

#3 [13.1] Aptamer recognition driven cascaded biocomputation on surface of serum-derived small extracellular vesicles

Multiplexed profiling of small extracellular vesicle (sEV) surface proteins holds promise for cancer diagnosis and prognosis due to the improved accuracy resulted from probing multiple biomarkers, yet simultaneously identifying these biomarkers on sEVs and directly reporting the analytical results remains a significant challenge. Here, we develo...

#4 [13.0] Self-Enhancing Photodynamic / Immunotherapy via a MOF Nanoplatform for Combined STING Activation and Immune Checkpoint Blockade.

Combinational photodynamic and immune checkpoint blockade (PDT/ICB) therapy is a promising approach for oncotherapy. However, the tumor microenvironment (TME) poses multiple biological barriers that can critically undermine the treatment outcomes of PDT/ICB. To this end, a cascade-amplified photodynamic immunotherapy nanoplatform based on the co...

#5 [13.0] Stimuli-Responsive DNA Tetrahedral Lysosome-Targeting Chimeras for Enhanced HER2 Protein Degradation.

Overexpression and abnormal activation of membrane proteins promote malignant tumor cell proliferation, while traditional interventions are often limited by drug resistance caused by target mutations. Here, we designed a stimulus-responsive DNA tetrahedron lysosome-targeted chimera (tFNA-LYTAC) strategy for degrading embrane proteins. Two tetrah...

#6 [12.8] Beyond the Needle: Is Liquid Biopsy the Future of Veterinary Medicine?

The detection of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) is a minimally invasive approach for diagnosing and monitoring cancer. These liquid biopsy-based strategies enable the identification of primary or metastatic tumors and provide valuable information on tumor biology and treatment response. A variety of techniques a...

#7 [11.5] Identification of melanotransferrin (MFI2) as a membrane target and an MFI2-directed aptamer as a theranostic tool for pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis and limited targeted therapeutic options. Melanotransferrin (MFI2) is a membrane-anchored protein that we found to be significantly upregulated in PDAC tissues and cell lines. MFI2 knockdown markedly reduced cell proliferation, migration, invasion, and epithelial-mesenchy...

#8 [11.4] Aptamer-Functionalized DNA Frameworks as Targeted Drug Buffers for Concentration Regulation of Maytansine.

Traditional chemotherapy often suffers from nonspecific distribution and poor drug concentration control, leading to compromised therapeutic efficacy and adverse effects. Mertansine (DM1), a potent cytotoxic agent with poor selectivity, dose-limiting toxicity, and a narrow therapeutic window, demands targeted delivery and precise concentration r...

#9 [11.3] Single-Exosome EpCAM Heterogeneity Profiling for Breast Cancer Diagnosis and Progression Monitoring.

Exosomes are nanoscale vesicles that are attractive for liquid biopsy, but most methods deliver ensemble averages and obscure how surface biomarkers vary across individual vesicles. We develop a single-particle impact electrochemistry (SPIE) assay to profile epithelial cell adhesion molecule (EpCAM) on single exosomes. EpCAM-positive vesicles ar...

#10 [11.1] Aptamer conjugated and oleuropein loaded PLGA nanoparticles increase the apoptosis of breast cancer cells.

Newer therapeutic strategies aim to increase the sensitivity of cancer cells to apoptosis. The phytochemical, oleuropein (OLP) has shown promising anticancer properties; however, its low bioavailability and non-specific delivery limit its anticancer potential. Therefore, we developed a novel aptamer-conjugated nanocarrier delivery system for the...

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