Aptamer 学术简报 — cancer — 2026-08-23

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 51 篇命中（aptamer 池 196 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [21.7] Bifunctional DNA multivalent structure integrating stable capture of urothelial carcinoma cells with CRISPR/Cas12a signal amplification for bladder cancer detection.

Noninvasive detection of bladder cancer remains challenging due to the limited analytical performance of current urine-based assays under realistic detection conditions. Here, we report a linear programmable DNA nanostructure that integrates multivalent aptamer recognition with CRISPR/Cas12a signal transduction for detecting tumor-derived urinar...

#2 [18.1] Integrated single-tube detection of miRNAs in subpopulation-specific extracellular vesicles via spatially colocalized dual-module DNA scaffold.

Extracellular vesicles (EVs)-derived miRNAs are valuable non-invasive biomarkers for early cancer diagnosis. However, most current methods detect either total EVs-miRNAs or those from a single subpopulation, overlooking subpopulation heterogeneity. Moreover, EVs isolation and miRNA analysis are often conducted in separate workflows, increasing s...

#3 [14.0] Targeting Adaptive and Innate Immune Responses with Covalent Aptamers.

Covalent aptamers have recently found initial success as tools for fast and selective transfer of labels to target proteins. Here, aptamers targeting protein tyrosine kinase 7 (PTK7) and the mesenchymal-epithelial transition factor (cMet) were functionalized with electrophiles capable of covalently transferring small-molecule immune recruiters. ...

#4 [13.8] A bioelectronic interface for continuous neuroinflammation monitoring and neuromodulation in Parkinson's disease model.

Neuroinflammation is increasingly recognized as a critical driver in the onset and progression of Parkinson's disease (PD), yet technologies capable of continuously tracking neuroinflammatory dynamics in vivo remain limited. Here, we report an implantable bioelectronic interface that integrates multiplexed aptamer based electrochemical biosensin...

#5 [13.2] Potentiating In Vivo Precision Cancer Therapy With Modularized Aptamer-Chemotherapeutics Conjugates Based on DNA Tiling-Mediated Structural Nanotechnology.

While DNA origami nanotubes have been often used in the biomedical field, the technical challenges in the assembly at large scale and the susceptibility to degradation limit their exploration for clinical application. In the current contribution, we propose a structural DNA nanotechnology (TMM) for the construction of a degradation-resistant DNA...

#6 [13.0] Catalytic BiFeO3/g-C3N4 Heterojunction Nanosheets Coupled with DNAzyme/Low-Leakage Sequential DNA Circuit for Ultrasensitive Electrochemical Aptamer-Based Detection of Colorectal Cancer Exosomes

Abstract Tumor-derived exosomes are promising circulating biomarkers for early colorectal cancer (CRC) diagnosis, yet their low abundance and the complexity of biological fluids demand sensing strategies with both stringent specificity and amplified signal output. Here, we report an ultrasensitive electrochemical aptasensor for SW620 cell-derive...

#7 [13.0] A signal-on fluorescent probe integrating Au@Ag NPs-based fluorescence resonance energy transfer quenching and enzyme-free catalytic hairpin assembly for c arcinoembryonic antigen detection.

Carcinoembryonic antigen (CEA) is a pivotal broad-spectrum tumor marker, yet its accurate quantification in early-stage cancer remains challenging due to the limited sensitivity and operational complexity of conventional immunoassays. We report a signal-on fluorescent probe that synergistically integrates the fluorescence resonance energy transf...

#8 [12.5] A sonogenetic antigen-presenting nanoplatform enables spatiotemporal control of calcium signalling in T cells for enhanced cancer immunotherapy.

Effective T-cell activation plays the critical role in cancer immunotherapy; however, strategies to precisely and sustainably stimulate antitumor T-cell responses while minimizing systemic toxicity remain limited. Here, we develop a sonogenetic artificial antigen-presenting cell (aAPC) platform for remote, spatiotemporally controlled Ca2+ influx...

#9 [12.4] Novel RNA aptamer HPE3 suppresses angiogenesis via inhibiting endocan–VEGF-A formation in Matrigel-implanted mice

Endocan is a vascular endothelial cell-secreted factor that is closely associated with angiogenesis and inflammation, regulates VEGF-A-mediated angiogenesis. While antibody- and siRNA-based strategies have targeted endocan, limitations in intracellular delivery and specificity have driven the development of aptamer-based therapeutics. In this st...

#10 [12.3] Ortho-Fusion Metaboliprobe for Sensitive and Specific In Situ Detection of Metabolites in Tumor-Derived Exosomes.

Small molecule metabolites carried by exosomes have emerged as promising biomarkers for cancer liquid biopsy. However, their clinical application is hindered by the complexity of blood components, the difficulty in distinguishing tumor-derived exosome subpopulations, and the low abundance of metabolites. Here, we develop an Ortho-Fusion Metaboli...

Methodology