Aptamer 学术简报 — cancer — 2026-08-18

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 43 篇命中（aptamer 池 160 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [26.9] Bifunctional DNA multivalent structure integrating stable capture of urothelial carcinoma cells with CRISPR/Cas12a signal amplification for bladder cancer detection.

Noninvasive detection of bladder cancer remains challenging due to the limited analytical performance of current urine-based assays under realistic detection conditions. Here, we report a linear programmable DNA nanostructure that integrates multivalent aptamer recognition with CRISPR/Cas12a signal transduction for detecting tumor-derived urinar...

#2 [22.9] Integrated single-tube detection of miRNAs in subpopulation-specific extracellular vesicles via spatially colocalized dual-module DNA scaffold.

Extracellular vesicles (EVs)-derived miRNAs are valuable non-invasive biomarkers for early cancer diagnosis. However, most current methods detect either total EVs-miRNAs or those from a single subpopulation, overlooking subpopulation heterogeneity. Moreover, EVs isolation and miRNA analysis are often conducted in separate workflows, increasing s...

#3 [17.7] A review of exosome isolation based on membrane protein recognition: Methods, performance, and challenges.

BACKGROUND: Exosomes participate in physiological and pathological processes such as intercellular communication, immune regulation, and tumor initiation and progression, holding significant potential in early disease diagnosis, therapeutic target identification, and drug delivery system development. However, the isolation of exosomes presents s...

#4 [14.8] Potentiating In Vivo Precision Cancer Therapy With Modularized Aptamer-Chemotherapeutics Conjugates Based on DNA Tiling-Mediated Structural Nanotechnology.

While DNA origami nanotubes have been often used in the biomedical field, the technical challenges in the assembly at large scale and the susceptibility to degradation limit their exploration for clinical application. In the current contribution, we propose a structural DNA nanotechnology (TMM) for the construction of a degradation-resistant DNA...

#5 [13.2] Harnessing Synergistic Enthalpy‐Entropy Regulation: An I‐Motif‐Based Modulating Design for Programming Stimulus‐Responsive DNA Switches

ABSTRACT DNA switches with target‐induced allostery show great potential in biomedical application, yet often remain unprogrammable responses and limited accuracy. Existing designs also lack adaptability beyond predefined response windows and offer limited sensitivity tuning. Herein, we present an i‐motif‐based modulating design that leverages e...

#6 [13.2] Harnessing Synergistic Enthalpy-Entropy Regulation: An I-Motif-Based Modulating Design for Programming Stimulus-Responsive DNA Switches.

DNA switches with target-induced allostery show great potential in biomedical application, yet often remain unprogrammable responses and limited accuracy. Existing designs also lack adaptability beyond predefined response windows and offer limited sensitivity tuning. Herein, we present an i-motif-based modulating design that leverages enthalpy-e...

#7 [12.7] A Fluorinated Dual-Functional Nanoassembly Induces Potent Antitumor Immunity via Programmable PD-L1 Suppression.

Antibody-mediated blockade of the PD-1/PD-L1 immune checkpoint has revolutionized cancer treatment. However, their efficacy is often limited by the compensatory upregulation of PD-L1 synthesis, which sustains surface expression upon blockade. FOXM1, a pivotal oncogenic transcription factor overexpressed in diverse cancers, directly transactivate...

#8 [12.7] TargetingAdaptive and Innate Immune Responses withCovalent Aptamers

Abstract Covalent aptamers have recently found initial success as tools for fast and selective transfer of labels to target proteins. Here, aptamers targeting protein tyrosine kinase 7 (PTK7) and the mesenchymal-epithelial transition factor (cMet) were functionalized with electrophiles capable of covalently transferring small-molecule immune rec...

#9 [12.5] Label-free electrochemical aptasensor for sensitive and selective recognition of N(6)-Methyladenosine: Applicability in human urine.

The specific and accurate detection of ultra-low levels of N6-methyladenosine (m6A) in biological samples holds great potential in the clinical diagnosis of various cancer types and neurodegenerative diseases. In this study, a cost-effective, label-free electrochemical aptasensor was developed by self-assembling a thiol-modified aptamer onto the...

#10 [12.3] In Situ Tracking of Membrane HER2- Antibody–Drug Conjugate Interaction with Surface PlasmonResonance Imaging

Abstract Antibody–drug conjugates (ADCs) rely on specific recognition of tumor-associated membrane receptors to achieve targeted intracellular drug delivery, yet in situ characterization of their interaction dynamics remains limited. Here, we develop a single-cell plasmonic imaging platform to quantitatively resolve the interaction between the m...

Methodology