Aptamer 学术简报 — cancer — 2026-08-13

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 49 篇命中（aptamer 池 200 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [21.7] A review of exosome isolation based on membrane protein recognition: Methods, performance, and challenges.

BACKGROUND: Exosomes participate in physiological and pathological processes such as intercellular communication, immune regulation, and tumor initiation and progression, holding significant potential in early disease diagnosis, therapeutic target identification, and drug delivery system development. However, the isolation of exosomes presents s...

#2 [15.9] A PD-L1-targeted and lactate-responsive DNA hydrogel enabling Mito-US therapy: dual functions for postsurgical cancer detection and eradication.

The minimal residual disease (MRD) following tumor resection remains a major challenge for preventing recurrence. Existing treatments usually exhibit poor specificity for scattered tumor cells at the surgical site. Moreover, few strategies successfully combine real-time MRD monitoring with sustained therapeutic intervention, further limiting the...

#3 [14.9] Harnessing Synergistic Enthalpy‐Entropy Regulation: An I‐Motif‐Based Modulating Design for Programming Stimulus‐Responsive DNA Switches

ABSTRACT DNA switches with target‐induced allostery show great potential in biomedical application, yet often remain unprogrammable responses and limited accuracy. Existing designs also lack adaptability beyond predefined response windows and offer limited sensitivity tuning. Herein, we present an i‐motif‐based modulating design that leverages e...

#4 [14.9] Harnessing Synergistic Enthalpy-Entropy Regulation: An I-Motif-Based Modulating Design for Programming Stimulus-Responsive DNA Switches.

DNA switches with target-induced allostery show great potential in biomedical application, yet often remain unprogrammable responses and limited accuracy. Existing designs also lack adaptability beyond predefined response windows and offer limited sensitivity tuning. Herein, we present an i-motif-based modulating design that leverages enthalpy-e...

#5 [14.6] Aptamer-integrated DNA tetrahedral sensors for cancer cell imaging and invasiveness assessment.

DNA tetrahedron is a nanoscale framework self-assembled from DNA strands. Their nucleic acid composition confers excellent biocompatibility, rendering them highly suitable for drug delivery and biomarker imaging applications. Aptamers are short oligonucleotides that bind target proteins with high affinity and specificity. Integration of multiple...

#6 [14.3] TargetingAdaptive and Innate Immune Responses withCovalent Aptamers

Abstract Covalent aptamers have recently found initial success as tools for fast and selective transfer of labels to target proteins. Here, aptamers targeting protein tyrosine kinase 7 (PTK7) and the mesenchymal-epithelial transition factor (cMet) were functionalized with electrophiles capable of covalently transferring small-molecule immune rec...

#7 [14.1] Fabrication of electrochemical biosensor with a CD36 aptamer and AuMoS(2) heterolayer for tumor-derived exosome detection.

Breast cancer (BC), which is often diagnosed at advanced stages owing to its asymptomatic progression, presents with substantial molecular heterogeneity, leading to diverse therapeutic responses and prognostic outcomes. Among its molecular subtypes, the human epidermal growth factor receptor 2-positive/hormone receptor-negative (HER2+/HR-) pheno...

#8 [13.3] A cascade-amplified Fe(3)O(4)-based nanoplatform for miRNA-21 sensing and combined apoptosis/ferroptosis induction.

A miRNA-21-responsive analytical nanoplatform based on Fe₃O₄@polydopamine (PDA) was constructed for co-delivery of doxorubicin (DOX) and functional nucleic acids, with glucose oxidase (GOx) immobilized to achieve cascade-amplified combined therapeutic effects; notably, the proposed self-supplying oxidative cascade is a proof-of-concept deduction...

#9 [13.2] Ligand-EngineeredMn-Cysteine as a Potent LaccaseMimic for CRISPR/Cas12a Electrochemical Biosensing of HepatocellularCarcinoma Biomarkers

Abstract Laccase is an environmentally friendly catalyst with water as the sole catalytic byproduct, yet its biomedical detection potential remains underexplored. Herein, a ligand engineering strategy was employed to synthesize Mn-cysteine nanoflowers (Mn-Cys NF) with laccase-mimicking activity via a one-pot method, using manganese (Mn) with ric...

#10 [13.2] Paper-based electrochemical aptasensor using Ti(3)C(2) MXene for sensitive detection of Mammaglobin-A biomarker.

Breast cancer is one of the most prevalent cancers worldwide and a leading cause of cancer-related mortality. However, early detection of the disease can significantly reduce the mortality rate of cancer patients. The current detection methods of breast cancer are expensive, time consuming, invasive and require professional assistance. To overco...

Methodology