Aptamer 学术简报 — cancer — 2026-08-09

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 51 篇命中（aptamer 池 206 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [28.9] A review of exosome isolation based on membrane protein recognition: Methods, performance, and challenges.

BACKGROUND: Exosomes participate in physiological and pathological processes such as intercellular communication, immune regulation, and tumor initiation and progression, holding significant potential in early disease diagnosis, therapeutic target identification, and drug delivery system development. However, the isolation of exosomes presents s...

#2 [18.4] A PD-L1-targeted and lactate-responsive DNA hydrogel enabling Mito-US therapy: dual functions for postsurgical cancer detection and eradication.

The minimal residual disease (MRD) following tumor resection remains a major challenge for preventing recurrence. Existing treatments usually exhibit poor specificity for scattered tumor cells at the surgical site. Moreover, few strategies successfully combine real-time MRD monitoring with sustained therapeutic intervention, further limiting the...

#3 [17.1] Aptamer-integrated DNA tetrahedral sensors for cancer cell imaging and invasiveness assessment.

DNA tetrahedron is a nanoscale framework self-assembled from DNA strands. Their nucleic acid composition confers excellent biocompatibility, rendering them highly suitable for drug delivery and biomarker imaging applications. Aptamers are short oligonucleotides that bind target proteins with high affinity and specificity. Integration of multiple...

#4 [16.9] Fabrication of electrochemical biosensor with a CD36 aptamer and AuMoS(2) heterolayer for tumor-derived exosome detection.

Breast cancer (BC), which is often diagnosed at advanced stages owing to its asymptomatic progression, presents with substantial molecular heterogeneity, leading to diverse therapeutic responses and prognostic outcomes. Among its molecular subtypes, the human epidermal growth factor receptor 2-positive/hormone receptor-negative (HER2+/HR-) pheno...

#5 [14.5] Ligand-EngineeredMn-Cysteine as a Potent LaccaseMimic for CRISPR/Cas12a Electrochemical Biosensing of HepatocellularCarcinoma Biomarkers

Abstract Laccase is an environmentally friendly catalyst with water as the sole catalytic byproduct, yet its biomedical detection potential remains underexplored. Herein, a ligand engineering strategy was employed to synthesize Mn-cysteine nanoflowers (Mn-Cys NF) with laccase-mimicking activity via a one-pot method, using manganese (Mn) with ric...

#6 [13.9] Tetraniline-Engineered Nickel Molecular Frameworks for Combinatorial NIR-Triggered Photothermal and Photodynamic Cancer Therapy

Near-infrared (NIR)-responsive nanomaterials are of critical importance for biomedical applications owing to their superior tissue penetration depths. Herein, we present a rational design of NIR-responsive tetraniline (TANI)-engineered nickel coordination frameworks for multimodal cancer phototheranostic applications. These frameworks represent ...

#7 [12.8] Photoactivated liquid-liquid phase separation-based cascade CRISPR/Cas12a electrochemical platform for sensitive small extracellular vesicles detection.

Small extracellular vesicles (sEVs) have emerged as promising liquid biopsy biomarker for gastric cancer (GC) diagnosis. However, profiling sEVs surface proteins in complex clinical matrices remains challenging by limited sensitivity and high background interference. In this study, we developed an electrochemical platform based on the photoactiv...

#8 [12.7] Stimuli-ResponsiveDNA Tetrahedral Lysosome-TargetingChimeras for Enhanced HER2 Protein Degradation

Abstract Overexpression and abnormal activation of membrane proteins promote malignant tumor cell proliferation, while traditional interventions are often limited by drug resistance caused by target mutations. Here, we designed a stimulus-responsive DNA tetrahedron lysosome-targeted chimera (tFNA-LYTAC) strategy for degrading embrane proteins. T...

#9 [12.3] Lock-Open: An AND Logic-Gated, Entropy-Driven DNA Nanowalker for Highly Sensitive Detection of UDG and APE1 Activities in Hepatocellular Carcinoma.

Early diagnosis of HCC remains a clinical challenge, with survival strongly dependent on reliable biomarkers and translatable detection tools. Herein, we establish uracil-DNA glycosylase (UDG) and apurinic/apyrimidinic endonuclease 1 (APE1) as diagnostic biomarkers for early-stage HCC and develop a lock-open strategy based on an AND logic-gated,...

#10 [12.3] Single-ElectrodeCOF-Based Multiplex PhotoelectrochemicalBiosensor with Combinatorial DNA Logic Gate for Intelligent Discriminationof Inflammatory Biomarkers

Abstract Simultaneous and accurate detection of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) is critical for the early diagnosis and monitoring of inflammatory diseases. However, conventional analytical methods are often cumbersome, time-consuming, and limited in the capacity for simultaneous multiplex analysis and rapid biomarke...

Methodology