Aptamer 学术简报 — cancer — 2026-08-08

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 38 篇命中（aptamer 池 177 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [19.1] A PD-L1-targeted and lactate-responsive DNA hydrogel enabling Mito-US therapy: dual functions for postsurgical cancer detection and eradication.

The minimal residual disease (MRD) following tumor resection remains a major challenge for preventing recurrence. Existing treatments usually exhibit poor specificity for scattered tumor cells at the surgical site. Moreover, few strategies successfully combine real-time MRD monitoring with sustained therapeutic intervention, further limiting the...

#2 [17.8] Aptamer-integrated DNA tetrahedral sensors for cancer cell imaging and invasiveness assessment.

DNA tetrahedron is a nanoscale framework self-assembled from DNA strands. Their nucleic acid composition confers excellent biocompatibility, rendering them highly suitable for drug delivery and biomarker imaging applications. Aptamers are short oligonucleotides that bind target proteins with high affinity and specificity. Integration of multiple...

#3 [17.7] Fabrication of electrochemical biosensor with a CD36 aptamer and AuMoS(2) heterolayer for tumor-derived exosome detection.

Breast cancer (BC), which is often diagnosed at advanced stages owing to its asymptomatic progression, presents with substantial molecular heterogeneity, leading to diverse therapeutic responses and prognostic outcomes. Among its molecular subtypes, the human epidermal growth factor receptor 2-positive/hormone receptor-negative (HER2+/HR-) pheno...

#4 [13.2] Photoactivated liquid-liquid phase separation-based cascade CRISPR/Cas12a electrochemical platform for sensitive small extracellular vesicles detection.

Small extracellular vesicles (sEVs) have emerged as promising liquid biopsy biomarker for gastric cancer (GC) diagnosis. However, profiling sEVs surface proteins in complex clinical matrices remains challenging by limited sensitivity and high background interference. In this study, we developed an electrochemical platform based on the photoactiv...

#5 [12.7] Lock-Open: An AND Logic-Gated, Entropy-Driven DNA Nanowalker for Highly Sensitive Detection of UDG and APE1 Activities in Hepatocellular Carcinoma.

Early diagnosis of HCC remains a clinical challenge, with survival strongly dependent on reliable biomarkers and translatable detection tools. Herein, we establish uracil-DNA glycosylase (UDG) and apurinic/apyrimidinic endonuclease 1 (APE1) as diagnostic biomarkers for early-stage HCC and develop a lock-open strategy based on an AND logic-gated,...

#6 [12.7] Single-ElectrodeCOF-Based Multiplex PhotoelectrochemicalBiosensor with Combinatorial DNA Logic Gate for Intelligent Discriminationof Inflammatory Biomarkers

Abstract Simultaneous and accurate detection of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) is critical for the early diagnosis and monitoring of inflammatory diseases. However, conventional analytical methods are often cumbersome, time-consuming, and limited in the capacity for simultaneous multiplex analysis and rapid biomarke...

#7 [12.4] An "off-on" fluorescent aptasensor based on FRET and magnetic beads for detection of circulating tumor cells in lung cancer.

Circulating tumor cells (CTCs) serve as critical biomarkers for early diagnosis, prognosis monitoring, and treatment response evaluation in lung cancer. Herein, we report a novel "off-on" fluorescent aptasensor based on fluorescence resonance energy transfer (FRET) and streptavidin-modified magnetic beads (MBs) for the sensitive and specific det...

#8 [12.4] High-sensitivity detection of alpha-fetoprotein via an unlabelled fluorescent probe based on switchable AIEE effect of a phenolic compound.

Alpha-fetoprotein (AFP) is a crucial cancer biomarker for the early screening and diagnosis of hepatocellular carcinoma. Here, we report the discovery of a phenolic compound, 5,5'- (anthracene- 9,10-diyl)bis(benzene-1,3-diol) (ABOL), exhibiting typical aggregation-induced emission enhancement (AIEE) effect. ABOL can bind to the nucleobases of th...

#9 [12.3] Ortho-FusionMetaboliprobe for Sensitive and SpecificIn Situ Detection of Metabolites in Tumor-Derived Exosomes

Abstract Small molecule metabolites carried by exosomes have emerged as promising biomarkers for cancer liquid biopsy. However, their clinical application is hindered by the complexity of blood components, the difficulty in distinguishing tumor-derived exosome subpopulations, and the low abundance of metabolites. Here, we develop an Ortho-Fusion...

#10 [12.3] Logic-GatedDual-Aptamer Proximity AlphaLISA for Rapidand Sensitive Detection of Tumor-Derived Small Extracellular Vesicles

Abstract Small extracellular vesicles (sEVs) have emerged as promising biomarkers for liquid biopsy; however, the limited specificity of single-marker detection and the intrinsic heterogeneity of circulating sEVs hinder their reliable clinical application. Herein, we develop a programmable dual-aptamer amplified luminescent proximity homogeneous...

Methodology