Aptamer 学术简报 — cancer — 2026-07-28

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 56 篇命中（aptamer 池 192 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.0] Molecular filling and metal ion-mediated DNA self-assembly strategy enable evaluation of lung cancer metastasis.

Accurately assessing the risk of lung cancer metastasis is crucial for improving patient prognosis and quality of life. In this study, we developed a rapid, homogeneous fluorescence detection system (DNA-N@Ag+@PIX) for lung cancer mesenchymal circulating tumor cells (M-CTCs) based on a molecular filling strategy and metal ion-mediated DNA self-a...

#2 [14.2] Detection of Point Mutation in Individual Living Circulating Malignant Cells by Targeting Molecular Beacon Delivery.

As a prevalent form of genetic alteration, single-base substitution serves as a critical determinant of targeted cancer therapeutic strategies and a driver of acquired drug resistance. Despite its clinical significance, detecting these mutations at the single-cell level remains challenging due to high costs, long analysis times, and difficulties...

#3 [13.9] A versatile strategy for oligonucleotide functionalization via on-support phosphitylation

Abstract Chemically modified nucleic acids such as antisense oligonucleotides, small interfering RNA and CRISPR guide RNA have emerged as transformative modalities in modern medicine, providing new strategies for the treatment of genetic and metabolic disorders, viral infections and cancer. However, their application is limited by challenges rel...

#4 [13.8] Human Epidermal Growth Factor Receptor 2 Dynamics Regulated by Actin-Filament Integrity on Cell Membranes Revealed by Single-Nanoconstruct Tracking.

This work demonstrates that the integrity of actin filaments can selectively regulate both lateral motion and in-plane orientation of transmembrane proteins on cell membranes. Using anisotropic gold nanostars functionalized with HER2 (human epidermal growth factor receptor)-targeting aptamers as optical probes, we tracked HER2 receptor dynamics ...

#5 [13.3] Self-Splicing RNA Platform Encodes Twin PROTACs for Dual-E3 Ligase Recruitment and Programmable Protein Degradation.

Proteolysis-targeting chimeras (PROTACs) offer a powerful strategy for targeted protein degradation but are frequently constrained by synthetic complexity and overreliance on a single-E3 ligase, leading to diminished efficacy in tumors with low or heterogeneous ligase expression. Here, we report a genetically encoded artificial self-splicing RNA...

#6 [13.3] Ultrasensitive Detection of Tumor-Derived Extracellular Vesicle microRNAs via Aptamer-Driven Targeted Membrane Fusion and Nonenzymatic Amplification.

Extracellular vesicles (EVs) have emerged as a prominent and rapidly evolving class of biomarkers, garnering an increasing amount of attention in recent years. The analysis of diverse EV-derived biomolecules, including proteins, mRNA, and miRNA, has driven the development of numerous innovative analytical technologies for EV detection. Neverthel...

#7 [13.3] Photothermal and colorimetric dual mode assay based on nanozymes for gastric cancer exosomes.

Exosome analysis in gastric cancer (GC) serum requires sensitive readout with reduced matrix interference. Circulating GC-related CD63-positive exosomes can indicate vesicle burden and stress-induced secretion. Herein, we developed a dual-mode photothermal/colorimetric aptasensor using CD63 aptamer-functionalized core-shell AuPt nanozymes for de...

#8 [13.2] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#9 [13.2] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#10 [12.1] A triangular split-DNAzyme scaffold for high-contrast microRNA imaging in living cells.

The 10-23 DNAzyme is a potent catalytic nucleic acid for biosensing; however, traditional single-blocker designs suffer from high background signal leakage due to spontaneous thermal "breathing." To overcome this, we engineered a triangular DNA probe-DNAzyme (TDPzyme) that spatially separates the enzyme components onto a rigid 3D scaffold. By sp...

Methodology