Aptamer 学术简报 — cancer — 2026-07-26

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 54 篇命中（aptamer 池 187 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [16.1] Molecular filling and metal ion-mediated DNA self-assembly strategy enable evaluation of lung cancer metastasis.

Accurately assessing the risk of lung cancer metastasis is crucial for improving patient prognosis and quality of life. In this study, we developed a rapid, homogeneous fluorescence detection system (DNA-N@Ag+@PIX) for lung cancer mesenchymal circulating tumor cells (M-CTCs) based on a molecular filling strategy and metal ion-mediated DNA self-a...

#2 [14.5] A versatile strategy for oligonucleotide functionalization via on-support phosphitylation

Abstract Chemically modified nucleic acids such as antisense oligonucleotides, small interfering RNA and CRISPR guide RNA have emerged as transformative modalities in modern medicine, providing new strategies for the treatment of genetic and metabolic disorders, viral infections and cancer. However, their application is limited by challenges rel...

#3 [14.5] Human Epidermal Growth Factor Receptor 2 Dynamics Regulated by Actin-Filament Integrity on Cell Membranes Revealed by Single-Nanoconstruct Tracking.

This work demonstrates that the integrity of actin filaments can selectively regulate both lateral motion and in-plane orientation of transmembrane proteins on cell membranes. Using anisotropic gold nanostars functionalized with HER2 (human epidermal growth factor receptor)-targeting aptamers as optical probes, we tracked HER2 receptor dynamics ...

#4 [14.0] Self-Splicing RNA Platform Encodes Twin PROTACs for Dual-E3 Ligase Recruitment and Programmable Protein Degradation.

Proteolysis-targeting chimeras (PROTACs) offer a powerful strategy for targeted protein degradation but are frequently constrained by synthetic complexity and overreliance on a single-E3 ligase, leading to diminished efficacy in tumors with low or heterogeneous ligase expression. Here, we report a genetically encoded artificial self-splicing RNA...

#5 [13.9] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#6 [13.9] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#7 [12.8] A triangular split-DNAzyme scaffold for high-contrast microRNA imaging in living cells.

The 10-23 DNAzyme is a potent catalytic nucleic acid for biosensing; however, traditional single-blocker designs suffer from high background signal leakage due to spontaneous thermal "breathing." To overcome this, we engineered a triangular DNA probe-DNAzyme (TDPzyme) that spatially separates the enzyme components onto a rigid 3D scaffold. By sp...

#8 [12.7] Integrated Low-Speed Isolation and Ultrasensitive In-Situ Detection of Glioblastoma EVs via UiO-66-NH 2 @Au Nanocomposite with Temperature Synergistic Membrane Fusion and Y-EXPAR Assay

Extracellular vesicles (EVs) secreted by glioblastoma (GBM) cells carry tumor-specific biomarkers such as microRNA-1246 (miR-1246), offering significant potential for noninvasive GBM detection. However, the efficient isolation of EVs from complex biofluids and ultrasensitive detection of their low-abundance miRNAs encapsulated in EVs remain form...

#9 [12.6] 3D-printed perovskite flowers on textile: a functional scaffold for aptamer based point-of-care breast cancer diagnostics.

A portable and disposable aptasensing strategy is introduced in this study, that has merged 3D printing, perovskite chemistry and aptasensor technology onto a textile fabric substrate. This work involves the synthesis and characterization of CeCuO3-LSCF perovskite nanocomposite (PNC) and its application in the fabrication of a 3D printed aptasen...

#10 [12.6] ETTAS: a modular aptamer-recruited platform for programmable translational activation.

Precise enhancement of endogenous protein synthesis offers a reversible therapeutic strategy without permanent genomic modification. However, existing Cas13-mediated translational activation systems are limited by modest potency and restricted modular expandability. Here, we developed the Enhanced Targeted Translational Activation System (ETTAS)...

Methodology