Aptamer 学术简报 — cancer — 2026-07-23

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 46 篇命中（aptamer 池 166 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [18.1] Molecular filling and metal ion-mediated DNA self-assembly strategy enable evaluation of lung cancer metastasis.

Accurately assessing the risk of lung cancer metastasis is crucial for improving patient prognosis and quality of life. In this study, we developed a rapid, homogeneous fluorescence detection system (DNA-N@Ag+@PIX) for lung cancer mesenchymal circulating tumor cells (M-CTCs) based on a molecular filling strategy and metal ion-mediated DNA self-a...

#2 [14.9] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#3 [14.9] Logic‐Responsive Superspherical Nucleic Acid Enables Tumor‐Specific Multiplexed Gene Silencing for Efficient Cancer Therapy

ABSTRACT Gene‐targeted therapies are of considerable interest for targeting multiple “undruggable” oncogenes. However, their therapeutic efficacy is largely hampered by off‐target toxicity and inherent tumor heterogeneity. Herein, we describe a logic‐responsive s uper s pherical n ucleic a cid (SSNA) with on‐demand, activatable functionality tha...

#4 [13.3] Dual-mode fluorescence and UV-vis aptasensor for hepatocellular carcinoma detection using magnetic separation.

A dual-mode aptasensor based on magnetic separation with a sequential signal conversion mechanism is developed for sensitive and specific detection of HepG2 cells. The system uses magnetic bead-labeled aptamers (MB-Apt, T1 strand), thiol-modified T2-functionalized silver nanoparticles (T2-AgNPs), and CdTe quantum dots (QDs). Without target cells...

#5 [13.2] Electrochemical biosensors for MLKL-related necroptosis biomarkers in lung cancer: From bench to clinical laboratory.

Lung cancer continues to be a leading cause of cancer-related mortality globally, necessitating the development of enhanced biomarkers for early detection and ongoing disease monitoring in clinical practice. Current diagnostic methodologies predominantly rely on imaging and tissue biopsy, which may not sufficiently capture the dynamic molecular ...

#6 [13.1] Biological properties of soluble CD146 and its role and mechanisms in disease progression

Soluble CD146 (sCD146) is a key circulating biomarker released from vascular endothelial cells via enzymatic cleavage under conditions of stress or activation.sCD146 not only dynamically reflects the integrity of the microvascular endothelial barrier but also profoundly drives the malignant progression of multisystem diseases through targeted in...

#7 [13.0] The versatile world of MXene nanohybrids: designed synthesis, functional diversity, and promising theranostics

MXenes, a rapidly expanding class of two-dimensional (2D) transition metal carbides, nitrides, and carbonitrides (Mₙ₊₁XₙTₓ), have emerged as transformative platforms for advanced analytical and biosensing technologies because of their metallic conductivity, tunable surface terminations, and high interfacial reactivity. This review establishes a ...

#8 [12.5] A wearable electrochemical aptamer platform based on microneedles for continuous real-time multiplexed hormone monitoring to advance hormone-related health management.

Real-time, multiplexed monitoring of sex hormones is essential for managing reproductive health and endocrine disorders. Traditional invasive blood sampling lacks the temporal resolution required to capture the dynamic hormonal fluctuations necessary for personalized clinical insights. Here, we present a wearable microneedle-based electrochemica...

#9 [12.1] Hairpin fuel-driven fluorogenic DNA aptamer amplifier for high-contrast imaging of microRNAs in living cells.

The spontaneous leakage and constitutive activity of the conventional fluorescent dye-labeled entropy-driven catalytic (EDC) circuit severely compromise the accuracy of low-abundance intracellular microRNAs (miRNAs) analysis. Herein, a Hairpin fuel-Driven Fluorogenic DNA Aptamer (HDFA) amplifier has been engineered for high-contrast imaging of m...

#10 [12.1] PAM-assembled CRISPR-Cas12a activation-based fluorescent and colorimetric dual-modal biosensor for detecting prostate cancer exosomes.

Prostate specific membrane antigen (PSMA)-positive exosomes hold significant potential for the diagnosis and risk assessment of prostate cancer. However, accurate detection is severely hindered by their low abundance in blood and interference from similarly sized particles. In this study, we have developed a protospacer adjacent motif (PAM)-asse...

Methodology