Aptamer 学术简报 — cancer — 2026-07-22

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 49 篇命中（aptamer 池 171 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [18.8] Molecular filling and metal ion-mediated DNA self-assembly strategy enable evaluation of lung cancer metastasis.

Accurately assessing the risk of lung cancer metastasis is crucial for improving patient prognosis and quality of life. In this study, we developed a rapid, homogeneous fluorescence detection system (DNA-N@Ag+@PIX) for lung cancer mesenchymal circulating tumor cells (M-CTCs) based on a molecular filling strategy and metal ion-mediated DNA self-a...

#2 [14.0] Electrochemical biosensors for MLKL-related necroptosis biomarkers in lung cancer: From bench to clinical laboratory.

Lung cancer continues to be a leading cause of cancer-related mortality globally, necessitating the development of enhanced biomarkers for early detection and ongoing disease monitoring in clinical practice. Current diagnostic methodologies predominantly rely on imaging and tissue biopsy, which may not sufficiently capture the dynamic molecular ...

#3 [13.5] Biological properties of soluble CD146 and its role and mechanisms in disease progression

Soluble CD146 (sCD146) is a key circulating biomarker released from vascular endothelial cells via enzymatic cleavage under conditions of stress or activation.sCD146 not only dynamically reflects the integrity of the microvascular endothelial barrier but also profoundly drives the malignant progression of multisystem diseases through targeted in...

#4 [12.5] Hairpin fuel-driven fluorogenic DNA aptamer amplifier for high-contrast imaging of microRNAs in living cells.

The spontaneous leakage and constitutive activity of the conventional fluorescent dye-labeled entropy-driven catalytic (EDC) circuit severely compromise the accuracy of low-abundance intracellular microRNAs (miRNAs) analysis. Herein, a Hairpin fuel-Driven Fluorogenic DNA Aptamer (HDFA) amplifier has been engineered for high-contrast imaging of m...

#5 [12.5] PAM-assembled CRISPR-Cas12a activation-based fluorescent and colorimetric dual-modal biosensor for detecting prostate cancer exosomes.

Prostate specific membrane antigen (PSMA)-positive exosomes hold significant potential for the diagnosis and risk assessment of prostate cancer. However, accurate detection is severely hindered by their low abundance in blood and interference from similarly sized particles. In this study, we have developed a protospacer adjacent motif (PAM)-asse...

#6 [11.7] In Situ SERS Monitoring of Membrane Protein Homo- and Hetero-Dimerizations at the Single-Cell Level.

Dimerization of cell membrane receptors governs essential cellular processes─including signal transduction, growth, proliferation, and apoptosis─yet precise discrimination between homo- and heterodimers remains a persistent technical challenge. To address this, we developed an in situ surface-enhanced Raman scattering (SERS) imaging strategy tha...

#7 [11.7] Aptamer-Modified Nanostructured Particles Exhibiting Sensitive Cell-Scale FRET Enable Precise Pancreatic Cancer Diagnosis.

Diagnosis of pancreatic cancer (PC) at early stage remains a challenge due to the limited sensitivity and specificity of current biomarkers. Here, we develop nanostructured magnetic particles (NMPs) exhibiting highly sensitive and specific circulating tumor cells (CTCs) quantification enabled by Förster resonance energy transfer (FRET), and demo...

#8 [11.7] Multivalence Aptamers Enhance Transmembrane Efficiency of Localized Catalytic Hairpin Assembly-Based Nanomachine for Sensitive Cell Imaging.

As a promising scaffold material, DNA tetrahedrons (TDNs) were integrated with localized catalytic hairpin assembly (LCHA) to develop a nanomachine. However, the TDN nanomachine, as an exogenous material, has difficulty directly penetrating the membrane, posing a bottleneck for cell imaging. To address this issue, multivalent aptamers were assem...

#9 [11.4] Development of Small Interfering RNA-Loaded Extracellular Vesicles via a High-Pressure Homogenization Approach

Extracellular vesicles (EVs) have garnered significant interest as potential bioderived drug delivery systems for RNA therapeutics owing to their distinctive characteristics, which include their inherent capability to transport various biological molecules throughout the body. However, several issues still pose challenges, such as the limited lo...

#10 [11.2] Therapeutic platforms for cancer management centered on blocking the PD-L1/PD-1 interaction through the use of aptamers: A review.

Blocking the PD-1/PD-L1 (Programmed Cell Death Protein-1/Programmed Cell Death Ligand-1) pathway represents a pivotal approach in cancer immunotherapy, effectively promoting sustained antitumor immune responses while alleviating immunosuppressive mechanisms. Advancing novel technologies to enhance the efficacy of PD-1/PD-L1 blockade remains a cr...

Methodology