Aptamer 学术简报 — cancer — 2026-07-15

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 75 篇命中（aptamer 池 253 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.8] A Targeted Nanozyme for STING Activation Improves BiTEs Therapy Outcomes in Colorectal Cancer.

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with limited efficacy of conventional therapies due to immunosuppressive tumor microenvironments and high recurrence. While bispecific T-cell engagers (BiTEs) show promise by engaging T cells against tumors, their clinical translation is hindered by poor stabi...

#2 [13.6] Therapeutic platforms for cancer management centered on blocking the PD-L1/PD-1 interaction through the use of aptamers: A review.

Blocking the PD-1/PD-L1 (Programmed Cell Death Protein-1/Programmed Cell Death Ligand-1) pathway represents a pivotal approach in cancer immunotherapy, effectively promoting sustained antitumor immune responses while alleviating immunosuppressive mechanisms. Advancing novel technologies to enhance the efficacy of PD-1/PD-L1 blockade remains a cr...

#3 [13.6] COF@DNAzyme Empowering Endogenous Copper for One‐Stitch Bioorthogonal Catalysis‐Based Anticancer Therapy

ABSTRACT Bioorthogonal chemistry, particularly the copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) reaction, holds great promise for in situ prodrug activation to minimize systemic toxicity in disease treatments. However, existing approaches mainly rely on exogenous copper catalysts, which pose a risk of disrupting copper homeostasis and suf...

#4 [13.6] COF@DNAzyme Empowering Endogenous Copper for One-Stitch Bioorthogonal Catalysis-Based Anticancer Therapy.

Bioorthogonal chemistry, particularly the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, holds great promise for in situ prodrug activation to minimize systemic toxicity in disease treatments. However, existing approaches mainly rely on exogenous copper catalysts, which pose a risk of disrupting copper homeostasis and suffer from ...

#5 [13.5] Multiplexed biosensing: A review of surface plasmon resonance platforms for biomarker analysis.

Surface plasmon resonance (SPR) has emerged as an important optical technology for the real-time, label-free analysis of biomolecular interactions. While its utility in detecting single analytes is well-established, the growing complexity of disease diagnostics demands tools capable of simultaneous multi-analyte detection. Many complex diseases,...

#6 [13.5] Non-Invasive Transdermal Delivery of miR-30a-5p via MUC1-Aptamer-Guided Tetrahedral DNA Nanostructures for Gene Silencing in Cutaneous Melanoma.

Cutaneous malignant melanoma is a highly aggressive skin cancer with poor prognosis. Although microRNA (miRNA)-based gene therapy shows promise, its clinical translation is limited by rapid degradation in serum and the barrier function of the stratum corneum. Herein, we engineer a programmable, targeted, and non-invasive nanoplatform, termed MAR...

#7 [13.3] Aptamer-based fluorescence "off-on" sensor for EGFR-positive lung cancer CTCs using streptavidin magnetic beads and N-CQDs@Ag⁺.

Circulating tumor cells (CTCs) are rare but critical biomarkers for lung cancer diagnosis and metastasis monitoring. We report an aptamer-based fluorescence "off-on" sensor for the sensitive and specific detection of epidermal growth factor receptor (EGFR)-positive lung cancer CTCs. The sensor integrates streptavidin magnetic beads (MBs) for tar...

#8 [13.0] Highly Efficient Isolation and Rapid Detection of Pancreatic Cancer-Derived Small Extracellular Vesicles by Specific Aggregation from Aptamer-Functionalized DNA Long Chains.

Small extracellular vesicles (sEV) are increasingly reported as biomarkers for the early diagnosis of pancreatic cancer (PC), but the current techniques for isolation and detection of sEV rely on expensive instruments and tedious protocols. In this work, a facile and rapid sEV isolation and detection method (LAPT-sEViso) was developed, which is ...

#9 [12.7] Membrane-anchored DNA nanodevice with allosteric aptamer arms enables parallel probing and on-site drug delivery.

DNA-based molecular computation enables targeting of cells via multiple surface receptors. However, existing platforms are often limited to single-receptor detection per operation or rely on freely diffusing components, a common source of off-target interference. Here we show an intelligent DNA nanodevice (DND) that integrates multivalent recogn...

#10 [12.2] A Droplet-Microarray Platform for Multiplex Profiling of Breast Cancer Exosome Subtypes in Patients' Blood Plasma Samples.

Breast cancer is highly heterogeneous, with distinct subtypes-luminal A, HER2-positive, and triple-negative-each exhibiting unique behaviors and treatment responses. Accurate identification of these subtypes is essential for guiding personalized therapies and improving outcomes. Exosomes, small extracellular vesicles secreted by tumor cells, hav...

Methodology