Aptamer 学术简报 — cancer — 2026-07-04

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 52 篇命中（aptamer 池 215 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [21.9] Multiplexed biosensing: A review of surface plasmon resonance platforms for biomarker analysis.

Surface plasmon resonance (SPR) has emerged as an important optical technology for the real-time, label-free analysis of biomolecular interactions. While its utility in detecting single analytes is well-established, the growing complexity of disease diagnostics demands tools capable of simultaneous multi-analyte detection. Many complex diseases,...

#2 [18.1] Next-generation electrochemical aptasensors for thrombin detection: the rise of aptamer-MOF architectures.

Thrombin is a crucial regulatory enzyme in the blood coagulation cascade that significantly influences cancer metastasis, cardiovascular disease, inflammation, and immunological regulation. Because of its dynamic, concentration-dependent activity, thrombin has emerged as a potential biomarker for the early diagnosis of a wide range of pathologic...

#3 [18.1] Self-assembled Nano-PROTACs: bridging chemical design and biological barriers in targeted protein degradation.

Self-assembled Nano-PROTACs represent an emerging class of programmable supramolecular degraders that integrate targeted protein degradation with nanoscale delivery to overcome the intrinsic limitations of conventional PROTACs. Conventional PROTACs are often constrained by poor solubility, limited membrane permeability, suboptimal pharmacokineti...

#4 [18.1] G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology.

INTRODUCTION: G-quadruplexes have emerged as a versatile class of oligonucleotides that combine molecular recognition, intrinsic anticancer activity and drug carrier functions, offering new opportunities to improve tumor selectivity and overcome limitations of conventional chemotherapy. AREAS COVERED: This review summarizes structural and biolog...

#5 [16.4] A photocurrent polarity switching photoelectrochemical aptasensor based on Er-MOF nanosheets and methylene blue for high-performance determination of CA15-3.

BACKGROUND: Photoelectrochemical (PEC) biosensors have attracted increasing interest for tumor biomarker detection due to their intrinsic advantages. However, conventional PEC sensing strategies are typically based on unidirectional "signal-on" or "signal-off" modes, which are vulnerable to matrix interferences in complex biological samples and ...

#6 [14.2] Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq.

Extracellular vesicles (EVs) have emerged as promising biomarkers for monitoring physiological homeostasis and pathological progression. However, current analytic methods face limitations in preserving spatial information about EVs and their intricate connections to parental and recipient cells. Here, we present Spatial-EV-seq, a method for in s...

#7 [13.0] Nanoparticles-assisted SELEX strategies for aptamer screening: a comprehensive review.

Aptamers, short oligonucleotide strands hold excellent potential for diverse applications in the field of biomedicine and bioanalytics such as drug delivery, bioimaging, biosensors, therapy and theranostics, thereby emerging as potential alternatives to antibodies. Since the introduction of SELEX (Systematic Evolution of Ligands by Exponential E...

#8 [12.8] Biofilm surface proximity-induced branched hybridization chain reaction strategy based on microchip electrophoresis for distinguishing exosomes from different cancer cells.

The exosome surface contains various cancer markers that can be suitable candidates for early cancer diagnosis and therapeutic efficacy evaluation. However, due to the very small size of exosomes, major challenges remain to detect tumor markers on their surface. To circumvent these challenges, a signal amplification strategy based on microchip e...

#9 [12.7] Structural DNA Nanotechnology-Based Branch-Sprouted Biomimetic Nanobamboo for Efficient Isolation of Rare Circulating Tumor Cells.

Because of very few sequence-identified viral scaffolds suitable for origami assembly and the unavailability of tile-based, nondeformable, superlarge DNA structures with architecturally defined collective properties, the biomedical application of structural DNA nanotechnology is hampered. In the current contribution, we demonstrate a backbone-in...

#10 [12.6] Naked-eye fluorescence sensing of aluminum using a bis(rhodamine)-phenyl hybrid for environmental monitoring and in vitro/in vivo bioimaging

A new probe, Rh-Ph-Rh, featuring two rhodamine groups attached to a phenyl ring, was developed. This hybrid compound serves multiple purposes: it turns on with a strong fluorescent signal in the presence of aluminum ions (Al3+) and can detect them at concentrations as low as 358 nM. When both Al3+ and cyanide ions (CN⁻) are present, fluorescence...

Methodology