Aptamer 学术简报 — cancer — 2026-06-23

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 45 篇命中（aptamer 池 166 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [28.9] A photocurrent polarity switching photoelectrochemical aptasensor based on Er-MOF nanosheets and methylene blue for high-performance determination of CA15-3.

BACKGROUND: Photoelectrochemical (PEC) biosensors have attracted increasing interest for tumor biomarker detection due to their intrinsic advantages. However, conventional PEC sensing strategies are typically based on unidirectional "signal-on" or "signal-off" modes, which are vulnerable to matrix interferences in complex biological samples and ...

#2 [13.8] Target-Specific Recognition and Standardized Readout: A DNA Nanotransduction Strategy for Nanopore Exosome Sensing toward Clinical Applications.

Solid-state nanopores are powerful single-molecule sensing tools, but their reliance on direct translocation requires high analyte concentrations and complicates biochemical specificity. We propose a DNA nanotransduction strategy featuring target-specific molecular recognition and standardized electrical readout, converting complex vesicular inf...

#3 [13.5] Engineered Lysosome-Targeted Protein Degradation via Hijacking Macropinocytosis.

Recently, targeted protein degradation (TPD) strategies have emerged as an effective tool for addressing undruggable targets in both biomedical research and the pharmaceutical industry, selectively binding proteins of interest and targeting them to the intracellular degradation machinery for degradation. However, the targeting of extracellular p...

#4 [12.9] An Engineered Core-Satellite Magnetic Aptasensor with Built-In Calibration and Regeneration for Accurate Quantification of Oral Cancer Exosomes.

Exosomes carry diverse biologically active substances that can be transferred between cells, thereby influencing physiological and pathological states of the organism. Abnormal exosome levels are closely associated with cancer. Consequently, the precise detection of exosomes holds considerable importance for noninvasive cancer diagnosis and moni...

#5 [12.7] Real-Time Monitoring of Trastuzumab Monoclonal Antibodies Using Electrochemical Aptamer-Based Sensors.

The real-time monitoring of trastuzumab (Tmab), a monoclonal antibody used for cancer treatment, is critical for personalized, response-guided dosing and improved biomanufacturing quality control. Currently, Tmab concentrations are quantified using immunoassays and mass spectrometry, but these platforms provide only discrete measurements and req...

#6 [12.7] A Biomimetic Dual-Targeting Nano-APA-Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy.

Targeting post-transcriptional dysregulation of tumor suppressors represents a new frontier in cancer therapy. Here, we identify the alternative polyadenylation (APA) regulator NUDT21 as a pivotal therapeutic target in oral squamous cell carcinoma (OSCC). NUDT21 is highly upregulated, correlating strongly with poor survival and advanced clinical...

#7 [11.8] A thiol-tolerant Au-Se anchored fluorescent aptamer nanosensor for GP73 detection with anti-interference validation and proof-of-concept serum/cellular imaging.

Golgi protein 73 (GP73) is a clinically relevant biomarker associated with hepatocellular carcinoma (HCC). However, fluorescence-based quantification and intracellular imaging are susceptible to interference and signal instability in thiol-rich biological environments. Herein, we report a fluorescent aptamer nanosensor based on Au-Se anchoring, ...

#8 [11.7] Engineering human PEG10-based nanoparticles for RNA self-packaging, delivery and cancer therapy

PEG10 protein was recently uncovered to self-assemble and self-package its own mRNA into nanoparticles, but the particles require expensive transfection for production and have yet to be explored for cancer therapy. Here we develop a human PEG10-based nanoparticles (PBNPs) platform for cargo RNA self-packaging and delivery for cancer therapy. We...

#9 [11.3] An Aptamer-Engineered Phenotyping System for Extracellular Vesicles Based on Honeycomb-like Melamine-Formaldehyde Microspheres and Carbon Dot Nanozymes.

Molecular phenotyping of extracellular vesicles (EVs) holds promise for noninvasive cancer diagnosis; however, current methodologies encounter limitations in cost, throughput, and sensitivity. Herein, we developed an aptamer-engineered phenotyping system designed for multiplexed, cost-effective, and user-friendly detection of EV membrane protein...

#10 [11.0] Ratiometric copper nanocluster fluorescence probe coupled with deep learning for intelligent recognition of tetracycline antibiotics in food

In this study, a ratiometric fluorescence sensing strategy combined with deep learning was developed for the intelligent detection of tetracycline antibiotics (TCs) in food matrices. Blue-emitting and saffron yellow-emitting copper nanoclusters (Cu NCs) were synthesized using bovine serum albumin (BSA) and 2,3,5,6-tetrafluorothiophenol (TFTP) as...

Methodology