Aptamer 学术简报 — cancer — 2026-06-16

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 41 篇命中（aptamer 池 155 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.0] A Biomimetic Dual-Targeting Nano-APA-Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy.

Targeting post-transcriptional dysregulation of tumor suppressors represents a new frontier in cancer therapy. Here, we identify the alternative polyadenylation (APA) regulator NUDT21 as a pivotal therapeutic target in oral squamous cell carcinoma (OSCC). NUDT21 is highly upregulated, correlating strongly with poor survival and advanced clinical...

#2 [14.1] Engineering human PEG10-based nanoparticles for RNA self-packaging, delivery and cancer therapy

PEG10 protein was recently uncovered to self-assemble and self-package its own mRNA into nanoparticles, but the particles require expensive transfection for production and have yet to be explored for cancer therapy. Here we develop a human PEG10-based nanoparticles (PBNPs) platform for cargo RNA self-packaging and delivery for cancer therapy. We...

#3 [13.7] An Aptamer-Engineered Phenotyping System for Extracellular Vesicles Based on Honeycomb-like Melamine-Formaldehyde Microspheres and Carbon Dot Nanozymes.

Molecular phenotyping of extracellular vesicles (EVs) holds promise for noninvasive cancer diagnosis; however, current methodologies encounter limitations in cost, throughput, and sensitivity. Herein, we developed an aptamer-engineered phenotyping system designed for multiplexed, cost-effective, and user-friendly detection of EV membrane protein...

#4 [13.3] Multifunctional DNA Nanoplatform Based on CuInS/ZnS QDs and Rolling Circle Amplification for Synergistic PTT/CDT/CT of Multidrug Resistant Cancer Cells.

Synergistic therapy holds significant potential in cancer diagnosis and treatment, yet faces substantial challenges such as nonspecific drug release and tumor multidrug resistance (MDR). Herein, we report a self-assembled DNA nanoplatform (ZCIS QDs@RD) based on CuInS/ZnS QDs (ZCIS QDs) and rolling circle amplification (RCA) for synergistic photo...

#5 [13.0] A Photosensitizer-Intercalated Programmable DNA System for Enhanced Photoimmunotherapy via Tumor Microenvironment Remodeling.

Photoimmunotherapy (PIT) has emerged as a minimally invasive therapeutic modality for cancer, offering high spatial precision and favorable therapeutic outcomes. However, the aggregation-caused quenching (ACQ) of photosensitizers and the hypoxic tumor microenvironment (TME) limit its overall efficacy. Herein, a DNA tetrahedron-based nanoplatform...

#6 [12.9] Programmable Chimeric Antigen Receptor T Cell Circuits With DNA Computing for Precision Tumor Therapy.

Chimeric antigen receptor (CAR) T cells, a promising cancer therapeutics, still face challenges in safety and efficacy due to the incapability to precisely regulate T cell activation. Here we develop a DNA-logic CAR (DL-CAR) system that enables programmable targeting and precise ablation of tumors with specific antigen combination patterns. The ...

#7 [12.8] DNA hydrogel-delivered hypoxic exosomes alleviate radiation-induced skin injury by stabilizing AKT.

BACKGROUND: Radiation-induced skin injury (RISI) is a common and refractory complication during tumor radiotherapy, characterized by radiation stress-induced impairment of keratinocyte viability and regenerative signaling, ultimately leading to delayed skin repair. Recently, hypoxia-preconditioned adipose-derived stem cell-derived exosomes (A-He...

#8 [12.6] Protamine-modified CuAu nanocarrier enhances aptamer-mediated synergistic therapy for breast cancer.

Although aptamers held promise for precision cancer therapy, their physiological instability and the lack of multifunctional delivery platforms that enabled synergistic therapeutic effects remained key challenges. In this study, a nanocarrier based on protamine-modified CuAu bimetallic nanozyme was constructed to co-load AT11 aptamer and Doxorub...

#9 [12.3] Functionalized Fluorescent Nanodiamonds Reveal Therapeutic Protein Clearance Through ENDOTAC Linked to AUTOTAC

Targeted protein degradation has emerged as a transformative therapeutic modality in cancer therapy, enabling the elimination of undruggable proteins and overcoming conventional small-molecule resistance. Therapeutic approaches such as endocytosis-targeting chimera (ENDOTAC) and autophagy-targeting chimera (AUTOTAC) facilitate undruggable protei...

#10 [11.2] Tracing Tumor-Derived Extracellular Vesicle Matrix Metalloproteinase 14 Using Dual-Target Orthogonal Barcoding-Based Microscale Thermophoretic Assays.

Longitudinal monitoring of tumor progression and metastasis provides significant benefits to improve the treatment outcome of breast cancer. Matrix metalloproteinase 14 (MMP14) on extracellular vesicles (EVs) is highly relevant to tumor invasiveness, yet the sensitivity and specificity of detection are hindered by tremendous amounts of normal EV...

Methodology