Aptamer 学术简报 — cancer — 2026-06-11

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 63 篇命中（aptamer 池 224 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.4] Engineered dual-fluorescence functional nucleic acid-based CRISPR/Cas12a biosensor for label-free ratiometric detection of site-specific DNA methylation.

The CRISPR/Cas12a system holds significant promise for biomedical applications. Nevertheless, the commonly used reporter, fluorophore-quencher-labeled substrates, is hindered by labor-intensive synthesis procedures and high costs, while also relying on a single-photon method and being vulnerable to environmental interference. Herein, a label-fre...

#2 [14.6] Programmable Chimeric Antigen Receptor T Cell Circuits With DNA Computing for Precision Tumor Therapy.

Chimeric antigen receptor (CAR) T cells, a promising cancer therapeutics, still face challenges in safety and efficacy due to the incapability to precisely regulate T cell activation. Here we develop a DNA-logic CAR (DL-CAR) system that enables programmable targeting and precise ablation of tumors with specific antigen combination patterns. The ...

#3 [14.1] An electrochemical biosensing platform based on α‑iron trioxide/ferriferrous oxide magnetic nanocomposites for early diagnosis of hepatocellular carcinoma.

The detection of biologically active proteins in complex biological matrices such as serum remains challenging. To enhance the sensitivity and accuracy of detecting the hepatocellular carcinoma biomarker stress-induced phosphoprotein 1 (STIP1), we proposed a label-free "Turn-off" electrochemical aptamer-based biosensing platform without requirin...

#4 [12.8] Tracing Tumor-Derived Extracellular Vesicle Matrix Metalloproteinase 14 Using Dual-Target Orthogonal Barcoding-Based Microscale Thermophoretic Assays.

Longitudinal monitoring of tumor progression and metastasis provides significant benefits to improve the treatment outcome of breast cancer. Matrix metalloproteinase 14 (MMP14) on extracellular vesicles (EVs) is highly relevant to tumor invasiveness, yet the sensitivity and specificity of detection are hindered by tremendous amounts of normal EV...

#5 [12.8] Electrochemically activated DNA circuit for the amplified and accurate biosensing of cancer cells.

The detection of cancer cells not only facilitates the early diagnosis of cancers but also provides valuable support for formulating personalized treatment plans for patients. In this work, we develop a new aptamer-based electrochemical biosensing method for cancer cell detection, employing an electrochemically activated DNA circuit as a signal ...

#6 [12.3] A Proximity-Induced pH-Responsive DNA Switch for Reversible Capture and Release of Extracellular Vesicles.

Extracellular vesicles (EV) serve as critical mediators in physiological and pathological processes, holding great promise for cancer diagnosis, real-time monitoring, and prognostic applications. However, their small size and low density present considerable challenges in achieving efficient, specific, and mild isolation, which currently hinders...

#7 [12.2] Modular Vaccine Robots for Spatiotemporal Programming of the CD4(+) T Cell-Myeloid Cell Axis.

Here, we developed a magnetically driven modular Janus vaccine robot (MVR) with orthogonally functional domains to achieve spatiotemporal coordination of CD4+ T cell-myeloid cell-mediated tumor killing. The oleic acid-modified CoFe2O4 (OA@CF) and carboxyl-modified T cell-targeting aptamers are selectively assembled onto the hydrophobic and hydro...

#8 [11.9] Nuclear-targeted CRISPR/Cas delivery by using aptamer-modified polymer lipid nanoparticles.

Efficient nuclear delivery of CRISPR/Cas ribonucleoproteins (RNP) remains a significant hurdle for non-viral systems. To address this, we developed a polymer-lipid hybrid nanoparticle functionalized with the AS1411 aptamer, targeting nucleolin to facilitate nucleus-directed delivery. Confocal imaging confirmed the accumulation of these aptamer-m...

#9 [11.9] Proteogenomic Analysis of Coronary Artery Calcification in Human Populations.

BACKGROUND: Joint use of multiple molecular layers can be useful to prioritize targets for mechanistic studies. Application of this approach to coronary disease in large populations is an emerging field. METHODS: We used reported circulating proteomic data (Somascan aptamer-based) from ≈3000 individuals in the CARDIA study (Coronary Artery Risk ...

#10 [11.9] CRISPR/Cas12a-driven miRNA-hypersensitive intelligent nanodrug release system for precision therapy of resistant triple-negative breast cancer

Methodology