Aptamer 学术简报 — cancer — 2026-06-02

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 73 篇命中（aptamer 池 236 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [26.8] Engineered dual-fluorescence functional nucleic acid-based CRISPR/Cas12a biosensor for label-free ratiometric detection of site-specific DNA methylation.

The CRISPR/Cas12a system holds significant promise for biomedical applications. Nevertheless, the commonly used reporter, fluorophore-quencher-labeled substrates, is hindered by labor-intensive synthesis procedures and high costs, while also relying on a single-photon method and being vulnerable to environmental interference. Herein, a label-fre...

#2 [25.3] An electrochemical biosensing platform based on α‑iron trioxide/ferriferrous oxide magnetic nanocomposites for early diagnosis of hepatocellular carcinoma.

The detection of biologically active proteins in complex biological matrices such as serum remains challenging. To enhance the sensitivity and accuracy of detecting the hepatocellular carcinoma biomarker stress-induced phosphoprotein 1 (STIP1), we proposed a label-free "Turn-off" electrochemical aptamer-based biosensing platform without requirin...

#3 [14.3] Carrier-free spherical nucleic acids engineered by coordination-competition for programmable release and cancer immunotherapy.

Oligonucleotide-based therapeutics offer precise genetic and immunological modulation but meet critical barriers including instability, poor cellular uptake, and carrier-associated toxicity. Although spherical nucleic acids (SNAs) provide a robust framework, the conventional designs relied on inactive cores impede multifunctional combinations an...

#4 [13.9] Structural characterization and molecular interaction studies of a novel RNA aptamer-MC1R macromolecular system using integrated computational and experimental approaches.

The structure-guided design of RNA aptamers targeting membrane proteins represents a growing opportunity, particularly given the therapeutic potential of nucleic acid therapeutics and the prevalence of G protein-coupled receptors (GPCRs) as drug targets. Here, we report an integrated computational and experimental approach to prioritize and stru...

#5 [13.7] Nucleic Acid Therapeutics for "Undruggable" Cancer Targets: Mechanisms, Challenges, and Prospects.

Despite significant advances in precision oncology, key oncoproteins such as Ras, MYC, and p53 remain historically difficult to drug. Conventional pharmacologic strategies are fundamentally constrained by their dependency on direct interactions with well-defined structural domains, which these targets lack. Nucleic acid therapeutics offer a tran...

#6 [13.7] Proximity-Catalyzed In Situ Anchoring Strategy for Fluorescence-Guided Precise Delineation of Minimal Residual Disease in Breast Cancer Surgery.

Minimal residual disease (MRD) after breast cancer surgery frequently triggers tumor recurrence and metastasis, creating an urgent unmet clinical need for accurate intraoperative MRD visualization. Conventional approaches, such as intraoperative histopathology and preoperative imaging, fail to provide adequate real-time surgical guidance. Their ...

#7 [13.5] Photoelectrochemical aptasensor for ultrasensitive detection of MUC1 based on titanium dioxide/polypyrrole/carboxy polyethylene glycol hybrid anti-fouling interface.

Achieving ultrasensitive detection of MUC1 in the early stages of breast cancer is critical for reducing mortality and improving patient prognoses. Photoelectrochemical sensing has emerged as a promising technology for the detection of MUC1, primarily due to its straightforward operation and user-friendly instrumentation. However, titanium dioxi...

#8 [13.5] A one-step electrochemical strategy for rapid exosome detection using Cu(2+)-coordinated DNA nanoparticles.

Stimulus-responsive nucleic acid nanomaterials are attractive for label-free electrochemical biosensing because their programmable structures enable target-triggered signal generation in homogeneous systems. Herein, we report a one-step electrochemical strategy for rapid and highly sensitive detection of ovarian cancer (OC)-derived exosomes base...

#9 [12.8] Screening molecular recognition element-based SWCNT optical sensors for the inflammatory cytokine TNF-α.

TNF-α (Tumor Necrosis Factor) is a proinflammatory cytokine that amplifies inflammatory response and promotes leukocyte recruitment. TNF-α is primarily produced by activated macrophages, among others, in response to infection, inflammation, or tissue damage. Given its central role in normal and abnormal immune responses, it is the target of seve...

#10 [12.7] DNA Tetrahedron-Mediated Sensing Platform on a Single Gold Nanowire: Special Signal Amplification, Self-Referencing Capability, and Cross-Validated Exosome Detection for Liver Cancer Liquid Biopsy.

Exosomes have emerged as promising biomarkers for noninvasive cancer diagnosis, while highly sensitive, reliable, and convenient assays remain challenging, particularly with conventional single-signal approaches. Herein, we report an exosome-tailored dual-mode self-referencing biosensing platform on a single gold nanowire (AuNW) substrate for th...

Methodology