Aptamer 学术简报 — cancer — 2026-06-01

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 70 篇命中（aptamer 池 248 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.7] Carrier-free spherical nucleic acids engineered by coordination-competition for programmable release and cancer immunotherapy.

Oligonucleotide-based therapeutics offer precise genetic and immunological modulation but meet critical barriers including instability, poor cellular uptake, and carrier-associated toxicity. Although spherical nucleic acids (SNAs) provide a robust framework, the conventional designs relied on inactive cores impede multifunctional combinations an...

#2 [14.2] Structural characterization and molecular interaction studies of a novel RNA aptamer-MC1R macromolecular system using integrated computational and experimental approaches.

The structure-guided design of RNA aptamers targeting membrane proteins represents a growing opportunity, particularly given the therapeutic potential of nucleic acid therapeutics and the prevalence of G protein-coupled receptors (GPCRs) as drug targets. Here, we report an integrated computational and experimental approach to prioritize and stru...

#3 [14.0] Nucleic Acid Therapeutics for "Undruggable" Cancer Targets: Mechanisms, Challenges, and Prospects.

Despite significant advances in precision oncology, key oncoproteins such as Ras, MYC, and p53 remain historically difficult to drug. Conventional pharmacologic strategies are fundamentally constrained by their dependency on direct interactions with well-defined structural domains, which these targets lack. Nucleic acid therapeutics offer a tran...

#4 [13.8] Photoelectrochemical aptasensor for ultrasensitive detection of MUC1 based on titanium dioxide/polypyrrole/carboxy polyethylene glycol hybrid anti-fouling interface.

Achieving ultrasensitive detection of MUC1 in the early stages of breast cancer is critical for reducing mortality and improving patient prognoses. Photoelectrochemical sensing has emerged as a promising technology for the detection of MUC1, primarily due to its straightforward operation and user-friendly instrumentation. However, titanium dioxi...

#5 [13.8] A one-step electrochemical strategy for rapid exosome detection using Cu(2+)-coordinated DNA nanoparticles.

Stimulus-responsive nucleic acid nanomaterials are attractive for label-free electrochemical biosensing because their programmable structures enable target-triggered signal generation in homogeneous systems. Herein, we report a one-step electrochemical strategy for rapid and highly sensitive detection of ovarian cancer (OC)-derived exosomes base...

#6 [13.1] Screening molecular recognition element-based SWCNT optical sensors for the inflammatory cytokine TNF-α.

TNF-α (Tumor Necrosis Factor) is a proinflammatory cytokine that amplifies inflammatory response and promotes leukocyte recruitment. TNF-α is primarily produced by activated macrophages, among others, in response to infection, inflammation, or tissue damage. Given its central role in normal and abnormal immune responses, it is the target of seve...

#7 [13.0] DNA Tetrahedron-Mediated Sensing Platform on a Single Gold Nanowire: Special Signal Amplification, Self-Referencing Capability, and Cross-Validated Exosome Detection for Liver Cancer Liquid Biopsy.

Exosomes have emerged as promising biomarkers for noninvasive cancer diagnosis, while highly sensitive, reliable, and convenient assays remain challenging, particularly with conventional single-signal approaches. Herein, we report an exosome-tailored dual-mode self-referencing biosensing platform on a single gold nanowire (AuNW) substrate for th...

#8 [13.0] Accurate Phenotyping at the Single-Exosome Level Using a Proximity-Ligation RCA-Based Light-Scattering Counting Platform for Breast Cancer Diagnosis.

Tumor-derived exosomes (TEXs), carrying rich proteomic information, have shown great promise as noninvasive biomarkers for cancer detection. However, their inherent heterogeneity, relatively low abundance, and significant interference from non-TEXs in biological fluids pose considerable challenges for accurate and sensitive TEX quantification. T...

#9 [13.0] Matrix-Boosted Electrochemiluminescence Biosensor for Ultrasensitive Exosome Detection and Automated Phenotype Discrimination.

Accurate quantification and phenotypic discrimination of exosomes in complex biological fluids remain technically challenging sensing issues, yet they are essential for early cancer diagnosis. To address this challenge, an ultrasensitive electrochemiluminescence (ECL) biosensor is engineered by integrating a "matrix-boosted" Cp-Pt-Ti3-xC2Ty MXen...

#10 [12.8] An intramolecular self-catalysis-boosted electrochemiluminescence biosensor for alpha fetoprotein detection in serum samples from liver cancer patients.

Constructing a highly boosted biosensor is critical for sensitive detection of trace targets in biological matrices with enhanced signal intensity and anti-interference capacity. Herein, an intramolecular self-catalysis-boosted electrochemiluminescence (ECL) biosensor is designed for alpha fetoprotein (AFP) detection, accompanying with entropy-d...

Methodology