Aptamer 学术简报 — cancer — 2026-05-31

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 56 篇命中（aptamer 池 212 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.3] Nucleic Acid Therapeutics for "Undruggable" Cancer Targets: Mechanisms, Challenges, and Prospects.

Despite significant advances in precision oncology, key oncoproteins such as Ras, MYC, and p53 remain historically difficult to drug. Conventional pharmacologic strategies are fundamentally constrained by their dependency on direct interactions with well-defined structural domains, which these targets lack. Nucleic acid therapeutics offer a tran...

#2 [14.1] A one-step electrochemical strategy for rapid exosome detection using Cu(2+)-coordinated DNA nanoparticles.

Stimulus-responsive nucleic acid nanomaterials are attractive for label-free electrochemical biosensing because their programmable structures enable target-triggered signal generation in homogeneous systems. Herein, we report a one-step electrochemical strategy for rapid and highly sensitive detection of ovarian cancer (OC)-derived exosomes base...

#3 [13.3] DNA Tetrahedron-Mediated Sensing Platform on a Single Gold Nanowire: Special Signal Amplification, Self-Referencing Capability, and Cross-Validated Exosome Detection for Liver Cancer Liquid Biopsy.

Exosomes have emerged as promising biomarkers for noninvasive cancer diagnosis, while highly sensitive, reliable, and convenient assays remain challenging, particularly with conventional single-signal approaches. Herein, we report an exosome-tailored dual-mode self-referencing biosensing platform on a single gold nanowire (AuNW) substrate for th...

#4 [13.3] Accurate Phenotyping at the Single-Exosome Level Using a Proximity-Ligation RCA-Based Light-Scattering Counting Platform for Breast Cancer Diagnosis.

Tumor-derived exosomes (TEXs), carrying rich proteomic information, have shown great promise as noninvasive biomarkers for cancer detection. However, their inherent heterogeneity, relatively low abundance, and significant interference from non-TEXs in biological fluids pose considerable challenges for accurate and sensitive TEX quantification. T...

#5 [13.3] Matrix-Boosted Electrochemiluminescence Biosensor for Ultrasensitive Exosome Detection and Automated Phenotype Discrimination.

Accurate quantification and phenotypic discrimination of exosomes in complex biological fluids remain technically challenging sensing issues, yet they are essential for early cancer diagnosis. To address this challenge, an ultrasensitive electrochemiluminescence (ECL) biosensor is engineered by integrating a "matrix-boosted" Cp-Pt-Ti3-xC2Ty MXen...

#6 [12.8] Digital droplet microfluidics integrating DNA walkers and CRISPR-Cas13a for simultaneous surface protein and miRNA profiling in single exosomes.

Tumor-derived exosomes carry multi-scale molecular signatures (e.g., surface proteins and nucleic acids) that reflect tumor heterogeneity, yet simultaneously profiling these biomarkers in single intact vesicles remains technically challenging. Herein, we developed a digital droplet microfluidic platform that integrates a DNA walker and a CRISPR/...

#7 [12.6] Robotic Centrifugal Microfluidics with In-Rotation Liquid Supply for the Extraction of Multiple Liquid Biopsy Analytes in One Platform

Background: The growing demand for versatile laboratory automation is exemplified in the context of liquid biopsy, where multi-analyte approaches are increasingly recognised for their potential to enhance diagnostic sensitivity in oncology. However, current practice often necessitates the use of dedicated instruments and workflows for the extrac...

#8 [12.3] Aptamer-Coupled Droplet CRISPR/Cas12a Enables Ultrasensitive sPD-L1 Detection.

Ultrasensitive detection of soluble programmed death-ligand 1 (sPD-L1) in peripheral blood is essential for early cancer diagnosis and immunotherapy monitoring. Conventional enzyme-linked immunosorbent assays lack the requisite sensitivity, whereas PCR quantifies nucleic-acid surrogates rather than the immunologically active protein. Here we rep...

#9 [12.0] Discovery and Cryo-EM-Guided Development of a Neuropilin-2-Binding Aptamer for Receptor Antagonism.

Receptor antagonists represent a major class of targeted cancer therapeutics, yet SELEX-based aptamer discovery often yields high-affinity binders that display limited functional blockade because epitope positioning is not explicitly selected. Herein, we report a multistage discovery and optimization workflow that integrates cell-SELEX, cryo-ele...

#10 [11.7] A magnetic separation-based dual-mode aptasensor integrating FRET fluorescence and UV absorption for early diagnosis of hepatocellular carcinoma.

Early diagnosis of hepatocellular carcinoma (HCC) is crucial for improving patient survival; however, conventional detection methods using HepG2 cells (a typical HCC cell line) have inherent limitations. To address this issue, we constructed a magnetic separation-based dual-mode aptasensor that integrates FRET fluorescence (using FAM-labeled apt...

Methodology