Aptamer 学术简报 — biosensor — 2026-10-01

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 123 篇命中（aptamer 池 201 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.2] Recognition Mechanism of Serotonin by a G‐Quadruplex–Duplex Hybrid Aptamer

ABSTRACT Serotonin is a key neurotransmitter, and aptamer‐based tools using the 44‐nt Apt44 have been successfully developed for its in vitro and in vivo detection. Nevertheless, the structural basis of recognition by this aptamer remains unclear. Here, we report high‐resolution NMR structures of Apt38, a 6‐nt truncated variant in the third loop...

#2 [14.2] Recognition Mechanism of Serotonin by a G-Quadruplex-Duplex Hybrid Aptamer.

Serotonin is a key neurotransmitter, and aptamer-based tools using the 44-nt Apt44 have been successfully developed for its in vitro and in vivo detection. Nevertheless, the structural basis of recognition by this aptamer remains unclear. Here, we report high-resolution NMR structures of Apt38, a 6-nt truncated variant in the third loop of Apt44...

#3 [14.0] Continuous Molecular Monitoring Using Electrochemical Aptamer-Based Sensors: Remaining Challenges for Long-Term In Vivo Deployment.

In vivo continuous molecular monitoring represents a long-standing, transformative objective in medicine, with the potential to fundamentally reshape disease diagnostics, therapeutic decision-making, and long-term patient management by providing dynamic biochemical information that is currently inaccessible. Electrochemical aptamer-based biosens...

#4 [14.0] Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

ABSTRACT Accurate and in situ detection of uracil‐DNA glycosylase (UDG) is crucial for clinical diagnosis and prognosis assessment. However, conventional methods show low accuracy, limited sensitivity, and off‐target signal leakage due to flawed signal input/output and amplification mechanisms. Therefore, an engineered allosteric biosensor (UUU‐...

#5 [13.9] Photoelectrochemical Fiber Cytometry With 60 nm Tip Size for Measuring Serotonin Dynamics at Edges of Cleft and Varicosities

ABSTRACT Tools and methods for investigating neurotransmitter dynamics at synaptic and nonsynaptic varicosities are essential for deciphering neural signaling events. Here, we first built a photoelectrochemical fiber cytometry with a tip size down to ∼60 nm for real‐time collection of photoelectrochemical signals in brain slices. Meanwhile, a se...

#6 [13.9] Photoelectrochemical Fiber Cytometry With 60 nm Tip Size for Measuring Serotonin Dynamics at Edges of Cleft and Varicosities.

Tools and methods for investigating neurotransmitter dynamics at synaptic and nonsynaptic varicosities are essential for deciphering neural signaling events. Here, we first built a photoelectrochemical fiber cytometry with a tip size down to ∼60 nm for real-time collection of photoelectrochemical signals in brain slices. Meanwhile, a serotonin (...

#7 [13.8] An ultrasensitive colorimetric platform for tetracycline based on the aptamer tailoring strategy and synergistic signal amplification of Au@Ce MOF.

In this study, a rapid Au@Ce MOF-Apt functionalized three-dimensional (3D) paper platform was constructed for the detection of TC in milk. To obtain a high-affinity aptamer (Apt), based on truncation and base mutation, resulting in high-affinity G-rich sequence aptamer (Apt-M24) (27 nt, -10.4 kcal/mol). Subsequently, the Apt-M24 was efficiently ...

#8 [13.8] Group detection of phthalates from mulches: Two competitive aptamer-based electrochemical approaches.

Phthalates, known as endocrine disruptors, are often contained in plastic-based materials and may enter food webs, threatening human health. In this study, an oligonucleotide-based competitive assay for phthalates detection was built on an electrochemical platform, based on poly(l-glutamic acid) and gold nanoparticles. Different assay formats we...

#9 [13.8] High-sensitivity simultaneous discrimination and detection of structurally similar adenosine phosphates via DNA aptamer conformational changes in α-hemolysin nanopore.

Adenosine phosphates (ATP, ADP, and AMP) play critical roles in cellular processes, yet their simultaneous detection remains challenging due to high structural similarity. To overcome this limitation, we developed a nanopore-aptamer sensing platform capable of tracking single-molecule binding dynamics in real time. This method leverages the spec...

#10 [13.8] Synergistic MIP-aptamer dual-recognition on silver-decorated sulfur-doped graphene quantum dots (S-GQDs@Ag) nanohybrids for ultra-sensitive impedimetric carcinoembryonic antigen detection.

The clinical utility of Carcinoembryonic Antigen (CEA) as a cornerstone biomarker for oncological monitoring is frequently hindered by the limitations of traditional immunoassays, including high costs, specialized storage requirements, and complex procedural workflows. To address these challenges, we report the development of a high-performance ...

Methodology