Aptamer 学术简报 — biosensor — 2026-09-29

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 96 篇命中（aptamer 池 164 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.9] Recognition Mechanism of Serotonin by a G‐Quadruplex–Duplex Hybrid Aptamer

ABSTRACT Serotonin is a key neurotransmitter, and aptamer‐based tools using the 44‐nt Apt44 have been successfully developed for its in vitro and in vivo detection. Nevertheless, the structural basis of recognition by this aptamer remains unclear. Here, we report high‐resolution NMR structures of Apt38, a 6‐nt truncated variant in the third loop...

#2 [14.9] Recognition Mechanism of Serotonin by a G-Quadruplex-Duplex Hybrid Aptamer.

Serotonin is a key neurotransmitter, and aptamer-based tools using the 44-nt Apt44 have been successfully developed for its in vitro and in vivo detection. Nevertheless, the structural basis of recognition by this aptamer remains unclear. Here, we report high-resolution NMR structures of Apt38, a 6-nt truncated variant in the third loop of Apt44...

#3 [14.7] Continuous Molecular Monitoring Using Electrochemical Aptamer-Based Sensors: Remaining Challenges for Long-Term In Vivo Deployment.

In vivo continuous molecular monitoring represents a long-standing, transformative objective in medicine, with the potential to fundamentally reshape disease diagnostics, therapeutic decision-making, and long-term patient management by providing dynamic biochemical information that is currently inaccessible. Electrochemical aptamer-based biosens...

#4 [14.7] Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

ABSTRACT Accurate and in situ detection of uracil‐DNA glycosylase (UDG) is crucial for clinical diagnosis and prognosis assessment. However, conventional methods show low accuracy, limited sensitivity, and off‐target signal leakage due to flawed signal input/output and amplification mechanisms. Therefore, an engineered allosteric biosensor (UUU‐...

#5 [14.6] Photoelectrochemical Fiber Cytometry With 60 nm Tip Size for Measuring Serotonin Dynamics at Edges of Cleft and Varicosities

ABSTRACT Tools and methods for investigating neurotransmitter dynamics at synaptic and nonsynaptic varicosities are essential for deciphering neural signaling events. Here, we first built a photoelectrochemical fiber cytometry with a tip size down to ∼60 nm for real‐time collection of photoelectrochemical signals in brain slices. Meanwhile, a se...

#6 [14.6] Photoelectrochemical Fiber Cytometry With 60 nm Tip Size for Measuring Serotonin Dynamics at Edges of Cleft and Varicosities.

Tools and methods for investigating neurotransmitter dynamics at synaptic and nonsynaptic varicosities are essential for deciphering neural signaling events. Here, we first built a photoelectrochemical fiber cytometry with a tip size down to ∼60 nm for real-time collection of photoelectrochemical signals in brain slices. Meanwhile, a serotonin (...

#7 [13.5] Matrix conditioning and magnetic bead target transfer for fluorescence aptamer-CRISPR/Cas12a detection of kanamycin in river water.

Fluorescence aptamer-CRISPR/Cas12a assays provide efficient signal conversion and amplification for the detection of small molecules. However, their practical application in complex environmental water remains limited. Matrix components can cause signal loss before CRISPR amplification. In this study, a fluorescence aptamer-CRISPR/Cas12a assay w...

#8 [13.3] Programmable Fc-encoded DNA tile-cube capture enables a thrombin-activated ratiometric ECL/SERS biosensor via a PAM-engineered toehold switch and CRISPR/Cas12a cleavage.

BACKGROUND: Accurate thrombin detection is important for coagulation-related assessment, but reliable quantification at ultralow levels remains challenging because matrix interference, electrode-to-electrode variation, and single-channel signal drift can compromise analytical accuracy. Herein, we developed a thrombin-responsive ratiometric elect...

#9 [13.1] Mechanistic insights into graphene quantum dots-mediated regulation of single-atom nanozyme activity for homogeneous dual-mode detection of acetamiprid.

A homogeneous colorimetric/ratiometric fluorescence biosensor was developed for acetamiprid (Ace) detection based on graphene quantum dots (GQDs)-regulated Fe/Mn-N-C single-atom nanozyme (SAzyme) activity. Aptamer-functionalized SAzymes with high peroxidase-like activity were hybridized with complementary DNA-modified GQDs (CS/GQDs) emitting flu...

#10 [12.8] Oxygen-vacancy-rich amorphous MnO(2)@MOF-808 nanozyme for dual-mode colorimetric and smartphone-assisted determination of Sr(2+) and H(2)O(2).

The rapid and specific monitoring of toxic strontium (Sr2+) contamination is critically important yet challenging, as it typically relies on non-portable and expensive instrumentation. Herein, the crystal-phase dependence of MnO2 nanozymes was systematically investigated by in situ growth of five representative polymorphs, α-, β-, γ-, δ- and amo...

Methodology