Aptamer 学术简报 — biosensor — 2026-09-28

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 91 篇命中（aptamer 池 157 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [15.2] Recognition Mechanism of Serotonin by a G-Quadruplex-Duplex Hybrid Aptamer.

Serotonin is a key neurotransmitter, and aptamer-based tools using the 44-nt Apt44 have been successfully developed for its in vitro and in vivo detection. Nevertheless, the structural basis of recognition by this aptamer remains unclear. Here, we report high-resolution NMR structures of Apt38, a 6-nt truncated variant in the third loop of Apt44...

#2 [15.0] Continuous Molecular Monitoring Using Electrochemical Aptamer-Based Sensors: Remaining Challenges for Long-Term In Vivo Deployment.

In vivo continuous molecular monitoring represents a long-standing, transformative objective in medicine, with the potential to fundamentally reshape disease diagnostics, therapeutic decision-making, and long-term patient management by providing dynamic biochemical information that is currently inaccessible. Electrochemical aptamer-based biosens...

#3 [14.9] Photoelectrochemical Fiber Cytometry With 60 nm Tip Size for Measuring Serotonin Dynamics at Edges of Cleft and Varicosities

ABSTRACT Tools and methods for investigating neurotransmitter dynamics at synaptic and nonsynaptic varicosities are essential for deciphering neural signaling events. Here, we first built a photoelectrochemical fiber cytometry with a tip size down to ∼60 nm for real‐time collection of photoelectrochemical signals in brain slices. Meanwhile, a se...

#4 [14.9] Photoelectrochemical Fiber Cytometry With 60 nm Tip Size for Measuring Serotonin Dynamics at Edges of Cleft and Varicosities.

Tools and methods for investigating neurotransmitter dynamics at synaptic and nonsynaptic varicosities are essential for deciphering neural signaling events. Here, we first built a photoelectrochemical fiber cytometry with a tip size down to ∼60 nm for real-time collection of photoelectrochemical signals in brain slices. Meanwhile, a serotonin (...

#5 [13.8] Programmable Fc-encoded DNA tile-cube capture enables a thrombin-activated ratiometric ECL/SERS biosensor via a PAM-engineered toehold switch and CRISPR/Cas12a cleavage.

BACKGROUND: Accurate thrombin detection is important for coagulation-related assessment, but reliable quantification at ultralow levels remains challenging because matrix interference, electrode-to-electrode variation, and single-channel signal drift can compromise analytical accuracy. Herein, we developed a thrombin-responsive ratiometric elect...

#6 [13.5] Mechanistic insights into graphene quantum dots-mediated regulation of single-atom nanozyme activity for homogeneous dual-mode detection of acetamiprid.

A homogeneous colorimetric/ratiometric fluorescence biosensor was developed for acetamiprid (Ace) detection based on graphene quantum dots (GQDs)-regulated Fe/Mn-N-C single-atom nanozyme (SAzyme) activity. Aptamer-functionalized SAzymes with high peroxidase-like activity were hybridized with complementary DNA-modified GQDs (CS/GQDs) emitting flu...

#7 [12.8] Shared-Output Aptamer-Gated DNA Nanodevices Program NbaSPARDA Trans-Cleavage for Metabolite and Drug Sensing.

Routing chemically distinct small-molecule aptamers into a common nuclease trans-cleavage pathway is constrained by the target-specific output handles of conventional structure-switching aptamers (SSAs). Shared-output aptamer-gated DNA nanodevices are designed so that recognition cores control release of the same short trigger DNA (tDNA). The re...

#8 [12.5] Aptamer-engineered signal-loaded MCOFs as a turn-on fluorescent platform for trace detection of immunosuppressants and prognostic biomarkers in serum.

The simultaneous detection of immunosuppressive drugs and prognostic biomarkers in the serum of post-transplant patients enables a more accurate assessment of patient status, allowing for timely adjustments to medication regimens and the prevention of graft-versus-host disease (GVHD). In this study, an ordered porous structure based on a covalen...

#9 [12.5] Entropy-driven strand displacement switches a DNA fluorescent light-up aptamer for label-free miRNA detection

#10 [12.3] Cascade-Amplified Microfluidic Detection of Tumor Biomarkers via Metal-DNA Nanospheres Activating CRISPR-Cas12a Assay

Abstract The development of ultrasensitive protein detection platforms is pivotal for early cancer diagnosis, yet existing methods are often constrained by inefficient “protein-to-signal” conversion and complex instrumentation. While CRISPR-Cas-based biosensors offer higher sensitivity for nucleic acids, their application in protein analysis is ...

Methodology