Aptamer 学术简报 — biosensor — 2026-09-27

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 77 篇命中（aptamer 池 136 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.4] Programmable Fc-encoded DNA tile-cube capture enables a thrombin-activated ratiometric ECL/SERS biosensor via a PAM-engineered toehold switch and CRISPR/Cas12a cleavage.

BACKGROUND: Accurate thrombin detection is important for coagulation-related assessment, but reliable quantification at ultralow levels remains challenging because matrix interference, electrode-to-electrode variation, and single-channel signal drift can compromise analytical accuracy. Herein, we developed a thrombin-responsive ratiometric elect...

#2 [13.2] Shared-Output Aptamer-Gated DNA Nanodevices Program NbaSPARDA Trans-Cleavage for Metabolite and Drug Sensing.

Routing chemically distinct small-molecule aptamers into a common nuclease trans-cleavage pathway is constrained by the target-specific output handles of conventional structure-switching aptamers (SSAs). Shared-output aptamer-gated DNA nanodevices are designed so that recognition cores control release of the same short trigger DNA (tDNA). The re...

#3 [12.8] Aptamer-engineered signal-loaded MCOFs as a turn-on fluorescent platform for trace detection of immunosuppressants and prognostic biomarkers in serum.

The simultaneous detection of immunosuppressive drugs and prognostic biomarkers in the serum of post-transplant patients enables a more accurate assessment of patient status, allowing for timely adjustments to medication regimens and the prevention of graft-versus-host disease (GVHD). In this study, an ordered porous structure based on a covalen...

#4 [12.7] Cascade-Amplified Microfluidic Detection of Tumor Biomarkers via Metal-DNA Nanospheres Activating CRISPR-Cas12a Assay

Abstract The development of ultrasensitive protein detection platforms is pivotal for early cancer diagnosis, yet existing methods are often constrained by inefficient “protein-to-signal” conversion and complex instrumentation. While CRISPR-Cas-based biosensors offer higher sensitivity for nucleic acids, their application in protein analysis is ...

#5 [12.6] Porous Transducers and Hybrid Recognition for Bulky Nitrosamine Impurities: Toward 3D–MXene–Aptamer Detection of Tricyclic NDSRIs

Pharmaceutical quality control faces an emerging problem with Tricyclic nitrosamine drug substance-related impurities (NDSRIs), for example, N-nitroso clozapine. The impurities preserve the compl ete structure of their parent active pharmaceutical ingredients, which consist of bulky lipophilic molecules with restricted conformational flexibility...

#6 [12.5] Antibody- and enzyme-free point-of-care detection of procalcitonin via synergistic nanomachines-activated catalytic assembly (SNCA) assay for early sepsis monitoring.

Procalcitonin (PCT) is an important biomarker for the early assessment and dynamic monitoring of sepsis. However, its routine measurement largely relies on centralized laboratory testing and protein-based recognition or signal-amplification components. Here, we developed an antibody- and enzyme-free synergistic nanomachines-activated catalytic a...

#7 [12.1] DNA origami-based lateral flow biosensors for detection of small molecule, protein, and nucleic acid.

Lateral flow assays (LFAs) are widely used in point-of-care diagnostics due to their rapid readout, low cost, and operational simplicity; however, their limited sensitivity hinders the detection of low-abundance biomarkers. Existing signal amplification strategies often fail to precisely modulate signal intensity while maintaining a simple and v...

#8 [12.1] Highly Sensitive Detection of Food Contaminants Based on an Efficient Quadrupedal DNA Walker

Abstract This research details the development of a highly efficient quadrupedal DNA walker designed for the detection of food contaminants. A cruciform DNA probe was synthesized through a straightforward methodology. Upon specific recognition between target analytes and aptamer sequences, the quadrupedal DNA walker is activated. This activation...

#9 [12.0] Electrospun nanofiber-based solid-phase extraction coupled with aptamer-mediated FRET assay for detection of aflatoxin M(1) in milk.

BACKGROUND: Aflatoxin M1 (AFM1), a highly toxic hydroxylated metabolite of aflatoxin B1, is a major contaminant of concern in milk and dairy products, posing significant risks to food safety and public health. Since AFM1 contamination is closely associated with feed quality, storage conditions, climatic factors, and farm management, reliable AFM...

#10 [11.9] A self-powered biosensing platform for U937 cell detection and the induction of mitochondrial aggregation.

An EBFC platform was developed for U937 cell detection via aptamer-triggered glucose oxidation. The generated electrons reduced cathode Fe3+, disrupting an alginate hydrogel to release mitochondrial-targeting nanoparticles. Intracellularly, ATP-induced DNA hybridization caused mitochondrial aggregation and ROS-mediated intervention, achieving cl...

Methodology