Aptamer 学术简报 — biosensor — 2026-09-24

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 73 篇命中（aptamer 池 124 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [16.2] Programmable Fc-encoded DNA tile-cube capture enables a thrombin-activated ratiometric ECL/SERS biosensor via a PAM-engineered toehold switch and CRISPR/Cas12a cleavage.

BACKGROUND: Accurate thrombin detection is important for coagulation-related assessment, but reliable quantification at ultralow levels remains challenging because matrix interference, electrode-to-electrode variation, and single-channel signal drift can compromise analytical accuracy. Herein, we developed a thrombin-responsive ratiometric elect...

#2 [14.2] Shared-Output Aptamer-Gated DNA Nanodevices Program NbaSPARDA Trans-Cleavage for Metabolite and Drug Sensing.

Routing chemically distinct small-molecule aptamers into a common nuclease trans-cleavage pathway is constrained by the target-specific output handles of conventional structure-switching aptamers (SSAs). Shared-output aptamer-gated DNA nanodevices are designed so that recognition cores control release of the same short trigger DNA (tDNA). The re...

#3 [13.5] Antibody- and enzyme-free point-of-care detection of procalcitonin via synergistic nanomachines-activated catalytic assembly (SNCA) assay for early sepsis monitoring.

Procalcitonin (PCT) is an important biomarker for the early assessment and dynamic monitoring of sepsis. However, its routine measurement largely relies on centralized laboratory testing and protein-based recognition or signal-amplification components. Here, we developed an antibody- and enzyme-free synergistic nanomachines-activated catalytic a...

#4 [13.1] Highly Sensitive Detection of Food Contaminants Based on an Efficient Quadrupedal DNA Walker

Abstract This research details the development of a highly efficient quadrupedal DNA walker designed for the detection of food contaminants. A cruciform DNA probe was synthesized through a straightforward methodology. Upon specific recognition between target analytes and aptamer sequences, the quadrupedal DNA walker is activated. This activation...

#5 [13.0] Electrospun nanofiber-based solid-phase extraction coupled with aptamer-mediated FRET assay for detection of aflatoxin M(1) in milk.

BACKGROUND: Aflatoxin M1 (AFM1), a highly toxic hydroxylated metabolite of aflatoxin B1, is a major contaminant of concern in milk and dairy products, posing significant risks to food safety and public health. Since AFM1 contamination is closely associated with feed quality, storage conditions, climatic factors, and farm management, reliable AFM...

#6 [12.9] A self-powered biosensing platform for U937 cell detection and the induction of mitochondrial aggregation.

An EBFC platform was developed for U937 cell detection via aptamer-triggered glucose oxidation. The generated electrons reduced cathode Fe3+, disrupting an alginate hydrogel to release mitochondrial-targeting nanoparticles. Intracellularly, ATP-induced DNA hybridization caused mitochondrial aggregation and ROS-mediated intervention, achieving cl...

#7 [12.8] Integrated microdroplet workflow for high-throughput cell-free transcription in double emulsion picoreactors.

Precise characterization of regulatory sequence performance is fundamental to synthetic biology and next-generation gene therapies, driving the need for scalable gene expression assays. While droplet-based microfluidics offers the ultra-high throughput required to scale these assays, it often depends on complex, custom fluorescence-activated dro...

#8 [12.8] Universal contamination-free nucleic acid biosensing enabled by guide-independent Argonaute amplicon elimination

Amplicon contamination remains a major challenge in nucleic acid biosensing, frequently compromising diagnostic accuracy in both clinical testing and field-deployable sensing systems. Although strategies such as uracil-DNA glycosylase (UDG) treatment and CRISPR-based approaches have been developed to mitigate this problem, their broader implemen...

#9 [12.8] A self-calibrating ratio fluorescence aptamer sensor based on PCN-224 for the highly sensitive detection of alternariol in cereals.

Alternariol (AOH) is an emerging mycotoxin widely found in agricultural products. It has drawn attention due to the potential health risks associated with long-term dietary exposure. Therefore, a ratiometric fluorescent aptamer sensor based on PCN-224 was developed. By combining the intrinsic fluorescence properties of PCN-224 with aptamer recog...

#10 [12.7] Rapid‐Forming Conductive Antifouling Hydrogel Coating Enables Magnetically Guided Electrochemical POCT for Direct at‑Home Blood Testing

ABSTRACT Electrochemical point‐of‐care testing for complex clinical samples is frequently hampered by matrix interference, signal instability, and laborious electrode modification procedures. Herein, we report a magnetic portable electrochemical immunosensor utilizing a conductive, anti‐fouling hydrogel coating composed of sodium alginate, polye...

Methodology