Aptamer 学术简报 — biosensor — 2026-09-23

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 77 篇命中（aptamer 池 130 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.5] Shared-Output Aptamer-Gated DNA Nanodevices Program NbaSPARDA Trans-Cleavage for Metabolite and Drug Sensing.

Routing chemically distinct small-molecule aptamers into a common nuclease trans-cleavage pathway is constrained by the target-specific output handles of conventional structure-switching aptamers (SSAs). Shared-output aptamer-gated DNA nanodevices are designed so that recognition cores control release of the same short trigger DNA (tDNA). The re...

#2 [13.4] Highly Sensitive Detection of Food Contaminants Based on an Efficient Quadrupedal DNA Walker

Abstract This research details the development of a highly efficient quadrupedal DNA walker designed for the detection of food contaminants. A cruciform DNA probe was synthesized through a straightforward methodology. Upon specific recognition between target analytes and aptamer sequences, the quadrupedal DNA walker is activated. This activation...

#3 [13.3] Electrospun nanofiber-based solid-phase extraction coupled with aptamer-mediated FRET assay for detection of aflatoxin M(1) in milk.

BACKGROUND: Aflatoxin M1 (AFM1), a highly toxic hydroxylated metabolite of aflatoxin B1, is a major contaminant of concern in milk and dairy products, posing significant risks to food safety and public health. Since AFM1 contamination is closely associated with feed quality, storage conditions, climatic factors, and farm management, reliable AFM...

#4 [13.1] Universal contamination-free nucleic acid biosensing enabled by guide-independent Argonaute amplicon elimination

Amplicon contamination remains a major challenge in nucleic acid biosensing, frequently compromising diagnostic accuracy in both clinical testing and field-deployable sensing systems. Although strategies such as uracil-DNA glycosylase (UDG) treatment and CRISPR-based approaches have been developed to mitigate this problem, their broader implemen...

#5 [13.0] Rapid‐Forming Conductive Antifouling Hydrogel Coating Enables Magnetically Guided Electrochemical POCT for Direct at‑Home Blood Testing

ABSTRACT Electrochemical point‐of‐care testing for complex clinical samples is frequently hampered by matrix interference, signal instability, and laborious electrode modification procedures. Herein, we report a magnetic portable electrochemical immunosensor utilizing a conductive, anti‐fouling hydrogel coating composed of sodium alginate, polye...

#6 [13.0] Development of a graphene oxide-based PEGylated fluorescent aptasensor with ultrahigh-sensitivity and anti-fouling properties for the detection of serum carcinoembryonic antigen levels.

The specificity and sensitivity of aptamer-based serum biomarker assays can be compromised by nonspecific adsorption of proteins. In this study, we used the carcinoembryonic antigen (CEA) aptamer as a model to develop a fluorescent aptasensor capable of specifically and sensitively detecting serum biomarkers. This aptasensor employs the good ant...

#7 [12.8] Machine learning-assisted broad-spectrum aptamer discovery and intelligent detection of neonicotinoid pesticides.

A machine learning-assisted computational strategy was developed for the de novo discovery of broad-spectrum aptamers targeting neonicotinoid pesticides (NEOs). Randomly generated DNA sequences were first classified according to secondary-structure similarity using t-distributed stochastic neighbor embedding (t-SNE) and K-means clustering, provi...

#8 [12.8] Thermosensitive NIR-II fluorescence nanotracer for targeted detection of sentinel lymph nodes

Current tracers for sentinel lymph node (SLN) biopsy in breast cancer suffer from limitations including poor accumulation, short retention times, and background staining interference at the surgical site. To address these shortcomings, we developed a dual-functional thermoresponsive nanotracer based on PbS quantum dots functionalized with poly(N...

#9 [12.3] High‐Performance Optical Fiber SPR Biosensor for Label‐Free Detection of miRNA‐588 Toward Osteosarcoma Diagnosis

ABSTRACT Osteosarcoma is a malignant bone tumor for which diagnosis is critical to patient prognosis. MicroRNA‐588 is downregulated in osteosarcoma, highlighting its potential as a diagnostic biomarker. However, its low abundance in body fluids makes sensitive detection difficult. This study presents a label‐free reflective optical fiber surface...

#10 [12.3] RPA-CRISPR/Cas12a and Aptamer-Based Electrochemical Biosensing Duplex Platform for On-Site Monitoring of Antimicrobial Resistance in Water

Abstract Monitoring antimicrobial resistance (AMR) in aquatic systems is essential for tracking resistance mechanisms and identifying microbial sources. Here, we present a dual-module electrochemical sensing platform that integrates a gold-electrode-based RPA–CRISPR/Cas12a biosensor for detecting antibiotic resistance genes (ARGs) with a paper-b...

Methodology