Aptamer 学术简报 — biosensor — 2026-09-18

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 84 篇命中（aptamer 池 137 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [16.4] Selection and validation of novel DNA aptamer panel co-specific to Plasmodium falciparum and Plasmodium ovale lactate dehydrogenase.

Malaria remains a major global health concern. The development of point-of-care diagnostic aptasensors could improve malaria detection, patient management, and eradication efforts. We selected and validated single-stranded DNA aptamers against Plasmodium falciparum lactate dehydrogenase (Pf-LDH), using systematic evolution of ligands by exponent...

#2 [14.7] Rapid‐Forming Conductive Antifouling Hydrogel Coating Enables Magnetically Guided Electrochemical POCT for Direct at‑Home Blood Testing

ABSTRACT Electrochemical point‐of‐care testing for complex clinical samples is frequently hampered by matrix interference, signal instability, and laborious electrode modification procedures. Herein, we report a magnetic portable electrochemical immunosensor utilizing a conductive, anti‐fouling hydrogel coating composed of sodium alginate, polye...

#3 [14.5] Thermosensitive NIR-II fluorescence nanotracer for targeted detection of sentinel lymph nodes

Current tracers for sentinel lymph node (SLN) biopsy in breast cancer suffer from limitations including poor accumulation, short retention times, and background staining interference at the surgical site. To address these shortcomings, we developed a dual-functional thermoresponsive nanotracer based on PbS quantum dots functionalized with poly(N...

#4 [14.0] High‐Performance Optical Fiber SPR Biosensor for Label‐Free Detection of miRNA‐588 Toward Osteosarcoma Diagnosis

ABSTRACT Osteosarcoma is a malignant bone tumor for which diagnosis is critical to patient prognosis. MicroRNA‐588 is downregulated in osteosarcoma, highlighting its potential as a diagnostic biomarker. However, its low abundance in body fluids makes sensitive detection difficult. This study presents a label‐free reflective optical fiber surface...

#5 [13.8] Highly specific aptamer-based structure-switching sensor for detection of the smallest alkali metal ion Li(+) in serum.

Lithium carbonate, a frontline drug for bipolar disorder (BD), requires strict therapeutic drug monitoring (TDM) due to its narrow therapeutic window (0.6-1.2 mM). Existing methods like inductively coupled plasma mass spectrometry (ICP-MS) and ion-selective electrodes (ISE) struggle to balance point-of-care testing (POCT) demands with interferen...

#6 [13.8] In situ monitoring of ferroptosis via dual-mode imaging of TFR1 expression using an aptamer-engineered MOF-Ag nanohybrid.

Ferroptosis is closely associated with the cytotoxicity of foodborne contaminants, with Transferrin Receptor 1 (TFR1) serving as a critical biomarker. Consequently, the in situ dynamic monitoring of TFR1 is crucial for unraveling the toxicological mechanisms underlying foodborne toxicity. To address the challenges of interference and insufficien...

#7 [13.5] Atomically dispersed ruthenium on magnetic layered double hydroxide nanozyme for a multi-mode aptasensor enabling highly sensitive kanamycin detection.

Kanamycin residues in food pose health risks due to their ototoxicity, nephrotoxicity, and antimicrobial resistance promotion. This work reports a multi-mode aptasensor combining atomically dispersed ruthenium-doped magnetic layered double hydroxide (RuSA/MLDH) with exonuclease I-assisted amplification. RuSA/MLDH exhibits DNA-enhanced peroxidase...

#8 [12.7] Fusion of a non-specific DNA-binding domain enhances Cas12a trans-cleavage for robust nucleic-acid diagnostics

CRISPR–Cas12a underlies powerful genome-editing and nucleic-acid detection technologies, yet its performance is limited by inefficient target engagement and low catalytic turnover, particularly at low target abundance and elevated temperatures. Here, we report a modular protein-engineering strategy to enhance Cas12a trans-activity by fusing the ...

#9 [12.6] Programmable Fc-encoded DNA tile-cube capture enables a thrombin-activated ratiometric ECL/SERS biosensor via a PAM-engineered toehold switch and CRISPR/Cas12a cleavage.

BACKGROUND: Accurate thrombin detection is important for coagulation-related assessment, but reliable quantification at ultralow levels remains challenging because matrix interference, electrode-to-electrode variation, and single-channel signal drift can compromise analytical accuracy. Herein, we developed a thrombin-responsive ratiometric elect...

#10 [12.4] Self-reduced anchoring of dispersed silver nanoparticles on Wurster COFs combined with graphene quantum dots: signal amplification for a femtomolar chlorpyrifos dual-recognition electrochemical aptasensor.

Accurate detection of the widely used organophosphorus pesticide chlorpyrifos (CPF) is of great significance for ecological systems and human health. In this study, a dual-recognition electrochemical sensing platform was constructed by assembling graphene quantum dots (GQDs) with highly dispersed Ag nanoparticles (AgNPs) anchored on Wurster-type...

Methodology