Aptamer 学术简报 — biosensor — 2026-09-16

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 93 篇命中（aptamer 池 146 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [17.7] Selection and validation of novel DNA aptamer panel co-specific to Plasmodium falciparum and Plasmodium ovale lactate dehydrogenase.

Malaria remains a major global health concern. The development of point-of-care diagnostic aptasensors could improve malaria detection, patient management, and eradication efforts. We selected and validated single-stranded DNA aptamers against Plasmodium falciparum lactate dehydrogenase (Pf-LDH), using systematic evolution of ligands by exponent...

#2 [14.5] Highly specific aptamer-based structure-switching sensor for detection of the smallest alkali metal ion Li(+) in serum.

Lithium carbonate, a frontline drug for bipolar disorder (BD), requires strict therapeutic drug monitoring (TDM) due to its narrow therapeutic window (0.6-1.2 mM). Existing methods like inductively coupled plasma mass spectrometry (ICP-MS) and ion-selective electrodes (ISE) struggle to balance point-of-care testing (POCT) demands with interferen...

#3 [14.5] In situ monitoring of ferroptosis via dual-mode imaging of TFR1 expression using an aptamer-engineered MOF-Ag nanohybrid.

Ferroptosis is closely associated with the cytotoxicity of foodborne contaminants, with Transferrin Receptor 1 (TFR1) serving as a critical biomarker. Consequently, the in situ dynamic monitoring of TFR1 is crucial for unraveling the toxicological mechanisms underlying foodborne toxicity. To address the challenges of interference and insufficien...

#4 [13.3] Programmable Fc-encoded DNA tile-cube capture enables a thrombin-activated ratiometric ECL/SERS biosensor via a PAM-engineered toehold switch and CRISPR/Cas12a cleavage.

BACKGROUND: Accurate thrombin detection is important for coagulation-related assessment, but reliable quantification at ultralow levels remains challenging because matrix interference, electrode-to-electrode variation, and single-channel signal drift can compromise analytical accuracy. Herein, we developed a thrombin-responsive ratiometric elect...

#5 [13.3] AuPt bimetallic nanocatalyst-amplified luminol-dissolved oxygen electrochemiluminescence for interferon-γ immunosensing

Interferon-γ (IFN-γ) is a pivotal inflammatory cytokine whose abnormal expression is associated with autoimmune disorders, infectious diseases, and cancer. Herein, a signal-off electrochemiluminescence (ECL) immunosensor was developed by integrating catalytic signal amplification with oriented antibody immobilization. An amino-functionalized ver...

#6 [12.8] Beyond the Needle: Is Liquid Biopsy the Future of Veterinary Medicine?

The detection of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) is a minimally invasive approach for diagnosing and monitoring cancer. These liquid biopsy-based strategies enable the identification of primary or metastatic tumors and provide valuable information on tumor biology and treatment response. A variety of techniques a...

#7 [12.7] Aptamer-Based Sensing with Fluorescent Light-Up DNA.

DNA aptamers are widely used in the construction of fluorescent sensors, typically employing labelled fluorophores as signaling indicators. However, this covalent labeling approach suffers from several limitations, including complex and costly chemical modification, incompatibility with long aptamer sequences, and susceptibility to false-positiv...

#8 [12.7] Self-Propagating Rolling Circle Amplification Enabled by a Dual-Function Fluorogenic Primer for Ultrasensitive Detection of Salmonella

Abstract Sensitive detection of foodborne pathogenic bacteria is essential for food safety monitoring and public health protection. Herein, we report a self-propagating hyperbranched rolling circle amplification (SP-HRCA) biosensing strategy enabled by a dual-function fluorogenic primer (DFP) for ultrasensitive detection of Salmonella. In this s...

#9 [12.3] Surface Topology-Regulated DNA Walking on Quasi-3D rGO Interfaces for Enhanced Electrochemical Kanamycin Sensing.

Three-dimensional (3D) DNA tracks, typically assembled on nanoparticles, can improve DNA walker performance by creating locally confined environments that increase the probability of successive walker-track encounters. However, these architectures often require complex multistep fabrication and are difficult to integrate with planar electrode pl...

#10 [12.2] Harmonizing amplification and cleavage kinetics through crRNA scaffold mutation enables robust one-pot CRISPR–Cas12 diagnostics

CRISPR-based diagnostics (CRISPR-Dx) integrated with isothermal nucleic acid amplification have emerged as a promising strategy for point-of-care molecular testing. Their practical deployment, however, remains constrained by workflow-related limitations. Conventional two-step formats are laborious and highly susceptible to aerosol contamination ...

Methodology