Aptamer 学术简报 — biosensor — 2026-08-22

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 111 篇命中（aptamer 池 182 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [22.5] Bifunctional DNA multivalent structure integrating stable capture of urothelial carcinoma cells with CRISPR/Cas12a signal amplification for bladder cancer detection.

Noninvasive detection of bladder cancer remains challenging due to the limited analytical performance of current urine-based assays under realistic detection conditions. Here, we report a linear programmable DNA nanostructure that integrates multivalent aptamer recognition with CRISPR/Cas12a signal transduction for detecting tumor-derived urinar...

#2 [21.1] Shell-thickness-modulated electrochemiluminescence of colloidal quantum dots for ultrasensitive PSA detection.

Electrochemiluminescence (ECL) biosensors hold great promise for clinical diagnostics, yet their performance is often constrained by the limited efficiency and stability of available luminophores in complex biological matrices. Colloidal quantum dots (QDs) have emerged as attractive alternatives to conventional emitters, but a systematic underst...

#3 [18.8] Integrated single-tube detection of miRNAs in subpopulation-specific extracellular vesicles via spatially colocalized dual-module DNA scaffold.

Extracellular vesicles (EVs)-derived miRNAs are valuable non-invasive biomarkers for early cancer diagnosis. However, most current methods detect either total EVs-miRNAs or those from a single subpopulation, overlooking subpopulation heterogeneity. Moreover, EVs isolation and miRNA analysis are often conducted in separate workflows, increasing s...

#4 [17.8] Steric hindrance effect synergizing hole-trapping technique: High-Stability and high-accuracy Si/CdS n-n heterojunction photoelectrochemical biosensing of amyloid-β42.

Due to rapid carrier recombination and photodegradation, cadmium sulfide (CdS), an n-type semiconductor photosensitive material, has a low utilization efficiency that restricts its use in biosensing. A synergistic hole-trapping approach utilizing steric hindrance effects is proposed in this paper. First, chemical bath deposition (CBD) is used to...

#5 [15.5] Electropolymerized Aptasensor for Femtogram-Level Cytokine Detection.

Detecting cytokines at ultralow concentrations is important for the early diagnosis and monitoring of inflammatory and immune disorders, yet remains constrained by the sensitivity and stability of bioelectronic interfaces. Here, we present an electropolymerization strategy for preparing poly(amino-ʟ-tyrosine) (pALT) nanofilms as functional bioin...

#6 [14.0] Near-Adjacent HeavyLanthanide Separation and SensingUsing Dimerizing Lanmodulins

Abstract Protein-based recovery, detection, and separation of rare earth elements (REs) have accelerated since the discovery of the lanmodulin (LanM) proteins. While exceptional at total RE recovery, prior proteins, like most ligands, exhibited limited ability to differentiate REs, whether in detection or separations. Here we report two dimerizi...

#7 [13.3] A signal-on fluorescent probe integrating Au@Ag NPs-based fluorescence resonance energy transfer quenching and enzyme-free catalytic hairpin assembly for c arcinoembryonic antigen detection.

Carcinoembryonic antigen (CEA) is a pivotal broad-spectrum tumor marker, yet its accurate quantification in early-stage cancer remains challenging due to the limited sensitivity and operational complexity of conventional immunoassays. We report a signal-on fluorescent probe that synergistically integrates the fluorescence resonance energy transf...

#8 [13.2] High-ThroughputOn-Chip Screening Enables Rapid Adaptationof DNA Aptamers to SARS-CoV-2 Evolution

Abstract Rapid pathogen evolution threatens public health by eroding the effectiveness of vaccines, therapeutics, and diagnostic tools. Although spike-protein-targeting monoclonal antibodies (mAbs) were developed within 10–12 months of the initial outbreak to serve as key theranostic agents, their redesign has struggled to keep pace with viral e...

#9 [13.0] Lanthanide Metal–Organic Frameworks Enable Target-Triggered CRISPR-Cas12a Activator Release for Ultrasensitive Non-nucleic Acid Biomarker Detection

Abstract Rapid, ultrasensitive detection of cardiac troponin I (cTnI) is critical for the early diagnosis of acute myocardial infarction (AMI). However, CRISPR-Cas systems, despite their unparalleled nucleic acid detection performance, face inherent bottlenecks in protein sensing, including inefficient signal transduction, high background noise,...

#10 [13.0] Corrigendum to "Construction of a multiplex biosensor for the on-site rapid detection of phthalates in biological fluids based on single-stranded DNA aptamers" [J Hazard Mater 499 (2025) 140164].

Methodology