Aptamer 学术简报 — biosensor — 2026-08-19

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 111 篇命中（aptamer 池 180 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [25.5] Bifunctional DNA multivalent structure integrating stable capture of urothelial carcinoma cells with CRISPR/Cas12a signal amplification for bladder cancer detection.

Noninvasive detection of bladder cancer remains challenging due to the limited analytical performance of current urine-based assays under realistic detection conditions. Here, we report a linear programmable DNA nanostructure that integrates multivalent aptamer recognition with CRISPR/Cas12a signal transduction for detecting tumor-derived urinar...

#2 [24.0] Shell-thickness-modulated electrochemiluminescence of colloidal quantum dots for ultrasensitive PSA detection.

Electrochemiluminescence (ECL) biosensors hold great promise for clinical diagnostics, yet their performance is often constrained by the limited efficiency and stability of available luminophores in complex biological matrices. Colloidal quantum dots (QDs) have emerged as attractive alternatives to conventional emitters, but a systematic underst...

#3 [21.6] Integrated single-tube detection of miRNAs in subpopulation-specific extracellular vesicles via spatially colocalized dual-module DNA scaffold.

Extracellular vesicles (EVs)-derived miRNAs are valuable non-invasive biomarkers for early cancer diagnosis. However, most current methods detect either total EVs-miRNAs or those from a single subpopulation, overlooking subpopulation heterogeneity. Moreover, EVs isolation and miRNA analysis are often conducted in separate workflows, increasing s...

#4 [20.6] Steric hindrance effect synergizing hole-trapping technique: High-Stability and high-accuracy Si/CdS n-n heterojunction photoelectrochemical biosensing of amyloid-β42.

Due to rapid carrier recombination and photodegradation, cadmium sulfide (CdS), an n-type semiconductor photosensitive material, has a low utilization efficiency that restricts its use in biosensing. A synergistic hole-trapping approach utilizing steric hindrance effects is proposed in this paper. First, chemical bath deposition (CBD) is used to...

#5 [15.0] Near-Adjacent HeavyLanthanide Separation and SensingUsing Dimerizing Lanmodulins

Abstract Protein-based recovery, detection, and separation of rare earth elements (REs) have accelerated since the discovery of the lanmodulin (LanM) proteins. While exceptional at total RE recovery, prior proteins, like most ligands, exhibited limited ability to differentiate REs, whether in detection or separations. Here we report two dimerizi...

#6 [14.2] High-ThroughputOn-Chip Screening Enables Rapid Adaptationof DNA Aptamers to SARS-CoV-2 Evolution

Abstract Rapid pathogen evolution threatens public health by eroding the effectiveness of vaccines, therapeutics, and diagnostic tools. Although spike-protein-targeting monoclonal antibodies (mAbs) were developed within 10–12 months of the initial outbreak to serve as key theranostic agents, their redesign has struggled to keep pace with viral e...

#7 [14.0] Corrigendum to "Construction of a multiplex biosensor for the on-site rapid detection of phthalates in biological fluids based on single-stranded DNA aptamers" [J Hazard Mater 499 (2025) 140164].

#8 [13.9] CRISPR RNA Engineering Enables Single Nucleotide Polymorphism Discrimination in Nucleic Acid Detection

ABSTRACT Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)‐based diagnostic systems have emerged as powerful platforms for sensitive nucleic acid detection, yet their clinical reliability is frequently constrained by off‐target activation and insufficient discrimination of closely related sequences. This review synthesizes curre...

#9 [13.7] Ortho-Fusion Metaboliprobe for Sensitive and Specific In Situ Detection of Metabolites in Tumor-Derived Exosomes.

Small molecule metabolites carried by exosomes have emerged as promising biomarkers for cancer liquid biopsy. However, their clinical application is hindered by the complexity of blood components, the difficulty in distinguishing tumor-derived exosome subpopulations, and the low abundance of metabolites. Here, we develop an Ortho-Fusion Metaboli...

#10 [13.7] Single-Electrode COF-Based Multiplex Photoelectrochemical Biosensor with Combinatorial DNA Logic Gate for Intelligent Discrimination of Inflammatory Biomarkers.

Simultaneous and accurate detection of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) is critical for the early diagnosis and monitoring of inflammatory diseases. However, conventional analytical methods are often cumbersome, time-consuming, and limited in the capacity for simultaneous multiplex analysis and rapid biomarker discrim...

Methodology