Aptamer 学术简报 — biosensor — 2026-08-08

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 105 篇命中（aptamer 池 177 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [20.1] AptaStick: A 3D-printed aptamer-functionalized stir-stick for selective extraction of bisphenol A from soft drinks.

This work presents AptaStick, a stereolithography 3D-printed stir-stick device functionalized with a bisphenol A (BPA)-specific aptamer for selective extraction from soft drinks. For this purpose, several geometries were evaluated to optimize extraction performance, with a star-shaped design providing the highest extraction efficiency and reprod...

#2 [19.1] A PD-L1-targeted and lactate-responsive DNA hydrogel enabling Mito-US therapy: dual functions for postsurgical cancer detection and eradication.

The minimal residual disease (MRD) following tumor resection remains a major challenge for preventing recurrence. Existing treatments usually exhibit poor specificity for scattered tumor cells at the surgical site. Moreover, few strategies successfully combine real-time MRD monitoring with sustained therapeutic intervention, further limiting the...

#3 [18.1] Aptamer-cDNA-driven nanozyme strategy: A recyclable dual-signal immunosensor for amplified detection of aflatoxin B(1) in edible oil.

Aflatoxin B1 (AFB1) poses a serious threat to human health, highlighting theurgent need for sensitive, precise and visual detection methods in daily foods. However,traditional detection methods relying on peroxidase (POD)-mimetic activity are susceptible to external interference, which increases false-positive or false-negative rates and comprom...

#4 [17.8] Aptamer-integrated DNA tetrahedral sensors for cancer cell imaging and invasiveness assessment.

DNA tetrahedron is a nanoscale framework self-assembled from DNA strands. Their nucleic acid composition confers excellent biocompatibility, rendering them highly suitable for drug delivery and biomarker imaging applications. Aptamers are short oligonucleotides that bind target proteins with high affinity and specificity. Integration of multiple...

#5 [17.7] Fabrication of electrochemical biosensor with a CD36 aptamer and AuMoS(2) heterolayer for tumor-derived exosome detection.

Breast cancer (BC), which is often diagnosed at advanced stages owing to its asymptomatic progression, presents with substantial molecular heterogeneity, leading to diverse therapeutic responses and prognostic outcomes. Among its molecular subtypes, the human epidermal growth factor receptor 2-positive/hormone receptor-negative (HER2+/HR-) pheno...

#6 [16.2] Surface activation and functionalization with aryl-diazonium chemistry enable biomolecules grafting on 3D printed carbon-based electrodes.

Carbon-based electrodes printed using fused deposition modelling (FDM) technology constitute appealing platforms for electrochemical biosensors. However, immobilizing bioreceptors that retain their stability and recognition properties at the electrode surface is quite challenging. So far, only few successful biosensors based on covalently bindin...

#7 [14.0] A novel label-free electrochemical aptamer sensor based on base mismatch and strand displacement for detection of kanamycin.

Misuse of kanamycin in animal husbandry has led to serious food safety issues. In this study, a label-free electrochemical aptasensor based on the base mismatch and strand displacement was developed for detection of kanamycin residue in agricultural products. A novel ferrocene-naphthalimide derivative was employed as the electroactive indicator....

#8 [13.2] Photoactivated liquid-liquid phase separation-based cascade CRISPR/Cas12a electrochemical platform for sensitive small extracellular vesicles detection.

Small extracellular vesicles (sEVs) have emerged as promising liquid biopsy biomarker for gastric cancer (GC) diagnosis. However, profiling sEVs surface proteins in complex clinical matrices remains challenging by limited sensitivity and high background interference. In this study, we developed an electrochemical platform based on the photoactiv...

#9 [13.0] AptaNexus:An AI-Driven Platform for Aptamer DataDiscovery and Intelligent Interaction

Abstract Aptamers are widely used in biosensing and targeted therapeutics, yet reported data remain fragmented across unstructured text, tables, and figures. Existing databases are limited in coverage and diversity, which constrains computational modeling. Here, we present AptaNexus (https://www.aptanexus.com/), a multitier aptamer database cont...

#10 [12.7] Lock-Open: An AND Logic-Gated, Entropy-Driven DNA Nanowalker for Highly Sensitive Detection of UDG and APE1 Activities in Hepatocellular Carcinoma.

Early diagnosis of HCC remains a clinical challenge, with survival strongly dependent on reliable biomarkers and translatable detection tools. Herein, we establish uracil-DNA glycosylase (UDG) and apurinic/apyrimidinic endonuclease 1 (APE1) as diagnostic biomarkers for early-stage HCC and develop a lock-open strategy based on an AND logic-gated,...

Methodology