Aptamer 学术简报 — biosensor — 2026-07-15

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 biosensor：近 14 天 151 篇命中（aptamer 池 253 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [17.8] High affinity and selective DNA aptamers for the detection of tobramycin in eye drops.

Tobramycin is a frontline aminoglycoside antibiotic with a narrow therapeutic window. Here, we report the selection of high-affinity DNA aptamers using a library-immobilization based SELEX strategy. The lead aptamer, TOB-2, binds tobramycin with a dissociation constant of 420 nM as determined by isothermal titration calorimetry, while exhibiting...

#2 [16.5] Magnetically induced aggregation-assisted mesoporous polydopamine/single-atom nanozyme platform for dual-channel detection and two-stage synergistic eradication of pathogens.

Contamination with foodborne pathogenic bacteria poses a severe threat to public health, necessitating the integration of detection with source sterilization technologies. Herein, we developed an integrated nanoplatform by combining an aptamer-modified mesoporous polydopamine/palladium single-atom carbon dot composite probe (MPDA/Pd SA@DA-CDs/Ap...

#3 [15.9] A Fentanyl-Responsive Microneedle Patch for Harm Reduction.

The efficacy of current opioid overdose interventions is fundamentally limited by their reliance on bystander detection and administration, leaving unwitnessed overdoses, a predominant cause of fatalities, unaddressed. Herein, we developed an innovative fentanyl-responsive microneedle (MN) patch (iNal patch) engineered as an autonomous harm redu...

#4 [14.5] Coordination‐Driven Metal‐Phenolic Network Complexes for Programmable Colorimetric Signal Transduction and Defined Nano‐Bio Interfaces

Self-assembled coordination networks provide opportunities to engineer functional nanostructures with programmable physicochemical properties, yet their optical responses and nano-bio interfacial interactions remain poorly understood. Herein, we employ a coordination-driven self-assembly approach to construct metal-phenolic network complexes (MP...

#5 [13.7] Colorimetric/Fluorescent/SERS Triple-Mode Synergistic Sensing for Highly Sensitive and Accurate Cardiac Troponin I Detection.

Cardiac troponin I (cTnI) is a cardiomyocyte-specific protein, and its serum level positively correlates with the degree of myocardial damage, making it a gold-standard biomarker for the clinical diagnosis of acute myocardial infarction (AMI). Nevertheless, conventional strategies for cTnI detection generally suffer from insufficient sensitivity...

#6 [13.5] Microscale thermophoresis sensor for homogeneous and one-step protein detection based on dual aptamers binding induced DNA switch.

Rapid and sensitive detection of proteins is in great demand in disease diagnostics, drug discovery, basic research, and other biomedical applications. The emerging microscale thermophoresis (MST) technique, which enables to monitor fluorescence responses of fluorescent molecules under heating in real time, provides an attractive avenue for sens...

#7 [13.5] Multiplexed biosensing: A review of surface plasmon resonance platforms for biomarker analysis.

Surface plasmon resonance (SPR) has emerged as an important optical technology for the real-time, label-free analysis of biomolecular interactions. While its utility in detecting single analytes is well-established, the growing complexity of disease diagnostics demands tools capable of simultaneous multi-analyte detection. Many complex diseases,...

#8 [13.3] An enhanced photoelectrochemical sensor based on CuBi(2)O(4)/HOF-101 heterojunction for highly sensitive detection of sulfadiazine.

A type-II heterojunction was constructed by integrating p‑type CuBi2O4 with n‑type HOF‑101 to enhance charge separation and transport. The resulting heterostructure generated a photocurrent response of 650 nA, more than twice that of pristine HOF‑101. Based on this improved photoactive interface, a photoelectrochemical aptasensor was developed f...

#9 [13.3] Aptamer-based fluorescence "off-on" sensor for EGFR-positive lung cancer CTCs using streptavidin magnetic beads and N-CQDs@Ag⁺.

Circulating tumor cells (CTCs) are rare but critical biomarkers for lung cancer diagnosis and metastasis monitoring. We report an aptamer-based fluorescence "off-on" sensor for the sensitive and specific detection of epidermal growth factor receptor (EGFR)-positive lung cancer CTCs. The sensor integrates streptavidin magnetic beads (MBs) for tar...

#10 [13.0] Highly Efficient Isolation and Rapid Detection of Pancreatic Cancer-Derived Small Extracellular Vesicles by Specific Aggregation from Aptamer-Functionalized DNA Long Chains.

Small extracellular vesicles (sEV) are increasingly reported as biomarkers for the early diagnosis of pancreatic cancer (PC), but the current techniques for isolation and detection of sEV rely on expensive instruments and tedious protocols. In this work, a facile and rapid sEV isolation and detection method (LAPT-sEViso) was developed, which is ...

Methodology