Aptamer 学术简报 — 2026-10-29

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 208 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [17.6] A bifunctional triblock zwitterionic copolymer combined with gold nanostars for antifouling electrochemical aptasensor to detect chloramphenicol in food samples.

To address the issue of electrochemical sensors being susceptible to fouling interference in complex food matrices, this work proposed a high-performance antifouling aptasensor based on a triblock zwitterionic copolymer and a gold nanostars (Au NSs) conductive substrate. Through precise control over the composition of two zwitterionic monomers [...

#2 [15.0] Amplifying the invisible: Liquid crystal-hydrogel microcavities decode trace Hg ions and aflatoxin B1.

Chinese herbal medicines (CHMs) have been applied to the prevention and treatment of numerous diseases. Ensuring the safety and pharmacological efficacy of CHMs demands precise detection of trace heavy metal ions and toxins, especially Hg and aflatoxin B1 (AFB1). However, due to subtle chemical signals, current technologies still make it challen...

#3 [14.9] Adaptation of a Fluorogenic RNA to N1-Methylpseudouridine Nucleoside Chemistry.

N1-methylpseudouridine (mΨ) is a modified nucleoside that entirely replaces uridine in the design of many therapeutic messenger RNAs (mRNA) to alleviate their intrinsic immunogenicity while preserving their capacity to be translated into protein. However, the impact of such replacement in functional non-coding RNAs has only been scarcely studied...

#4 [14.8] Beyond Static Architectures: Responsive Tetrahedral Framework Nucleic Acids for Precise Theranostics.

Precise theranostics requires spatiotemporal control and high specificity to adapt to complex physiological microenvironments. Tetrahedral framework nucleic acids (tFNA), classic 3D DNA nanostructures, offer distinct advantages such as atomic-level structural precision, intrinsic programmability, and excellent biocompatibility. While traditional...

#5 [14.8] Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers.

Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmable artificial immunological interface to redirect cytotoxic T cells toward ca...

#6 [14.0] Phosphate‐Engineered DNA Reporters Boost CRISPR‐Cas12a Trans ‐Cleavage for Rapid and Sensitive Nucleic Acid Detection

ABSTRACT CRISPR–Cas12a molecular diagnostics rely on target‐activated collateral cleavage of single‐stranded DNA (ssDNA) reporters to generate fluorescence signals, yet the mechanisms governing reporter substrate processing remain poorly understood. Here we show that Cas12a trans ‐cleavage involves both endonucleolytic cleavage and exonucleolyti...

#7 [13.9] Time‐Resolved Multidimensional NMR Spectroscopy Reveals the Bifurcated Folding Pathway of a Thrombin‐Binding DNA G4–Azobenzene Derivative Complex

ABSTRACT Resolving the complex folding landscape of biomolecules contributes greatly to understanding cellular function, since cellular regulation and signal transduction are often linked to their conformational dynamics. We here investigate conformational transitions of a DNA deoxyguanosine G‐quadruplex (G4) induced by binding of a low molecula...

#8 [13.9] Time-Resolved Multidimensional NMR Spectroscopy Reveals the Bifurcated Folding Pathway of a Thrombin-Binding DNA G4-Azobenzene Derivative Complex.

Resolving the complex folding landscape of biomolecules contributes greatly to understanding cellular function, since cellular regulation and signal transduction are often linked to their conformational dynamics. We here investigate conformational transitions of a DNA deoxyguanosine G-quadruplex (G4) induced by binding of a low molecular weight ...

#9 [13.7] Unconventional DNA architecture in a dopamine–bound aptamer complex

Abstract Aptamers are oligonucleotides that have been selected to bind a particular target. Despite the growing popularity of functional DNA aptamers, there remains limited knowledge of their binding mechanisms, as few have been characterized at the atomic level. Here, we use NMR spectroscopy to obtain structural details of RKEC1, a shortened ve...

#10 [13.7] Exosome‐Inspired Proteolipid Nanoparticles Enable Safe, Extrahepatic RNAi–Chemo Therapy Through Cholesterol‐Free, Tumor‐Preferential Delivery

Lipid nanoparticle (LNP)-enabled genetic medicines are reshaping cancer therapy yet remain constrained by liver-biased tropism, dose-limiting toxicities, and limited efficacy in refractory solid tumors such as pancreatic ductal adenocarcinoma (PDAC). Here, exosome-inspired proteolipid nanoparticles (Em-pLNPs) are developed to embed three exosoma...

Methodology