Aptamer 学术简报 — 2026-10-21

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 175 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [18.4] Triple quenching strategy-based highly sensitive electrochemiluminescence sensor for perfluorooctanoic acid.

Quenching-based electrochemiluminescence (ECL) sensing boasts prominent advantages for trace analysis, while single-mechanism systems have inherent flaws, making the development of efficient synergistic quenching strategies of great practical significance for ultra-trace perfluorooctanoic acid (PFOA) detection. In this work, a zinc-coordinated p...

#2 [18.2] A dual-aptamer colorimetric sensor based on Cu-MOF@PtPdNPs for the highly sensitive detection of MUC1.

The abnormally high expression of MUC1 in various malignant tumors makes it a crucial biomarker for early cancer diagnosis. This study synthesized a Cu-MOF@PtPdNPs nanocomposite exhibiting robust peroxidase-like activity via an in-situ reduction method. By integrating this nanomaterial with a dual-aptamer recognition sandwich strategy, an effici...

#3 [15.2] A Bispecific Nanobridge Derived from Immunogenic Tumor Membranes Restores Dendritic Cell-T Cell Crosstalk for Enhanced Solid Tumor Immunotherapy.

In solid tumors, communication between dendritic cells (DCs) and T cells is impaired by poor immune infiltration and lack of physical contact, limiting current immunotherapies. Here, we develop a bispecific immune-bridging platform (NVMB) to address these limitations. NVMB consists of tumor cell membrane-derived nanovesicles enriched with damage...

#4 [14.3] Digitally Printed Gold Nanoelectronics for Tap-to-Detect Electrochemical Biosensing and Chemical Sensing.

Printed electrochemical sensors offer a promising route toward decentralized diagnostics and environmental monitoring, but their practical use remains constrained by complex electrode fabrication and instrument-dependent readout. Here, we present a tap-to-detect sensing platform that couples digitally printed gold nanoparticle nanoelectronics wi...

#5 [14.0] PK-Tracker: A Real-Time Bedside Device for Continuous Therapeutic Drug Monitoring.

Medical procedures often require the administration of drugs, whose dosing is typically guided by pharmacodynamic responses rather than direct measurement of concentrations. This limitation largely arises from traditional monitoring procedures that rely on repeated venous sampling followed by laboratory analyses using cumbersome and costly instr...

#6 [13.9] Optimizing Endosomal Escape for Effective Aptamer-Based Ubiquitin-Mediated Degradation of c-Met.

Endosomal escape is a significant challenge in the delivery of nucleic acid therapeutics, which also limits the cytosolic activity of aptamers that bind membrane proteins and enter cells by endocytosis. Here, we systematically mapped the colocalization of the c-Met targeting aptamer SL1 with early, recycling, and late endosomes following endocyt...

#7 [13.7] Cryo-Engineered DNA Cryogels with Interconnected Macroporous Architectures for Enhanced Mass Transfer and Ultrasensitive cTnI Detection via an Integrated Microfluidic Platform

Abstract Cardiac Troponin I (cTnI) is a definitive clinical biomarker for the diagnosis of acute myocardial infarction (AMI). Thus, its rapid and precise quantification is of paramount significance for clinical intervention. DNA hydrogels represent a premier choice for constructing rapid detection platforms due to their excellent target responsi...

#8 [13.3] Highly-Time-Resolved Measurements of Tryptophan's Distribution and Homeostatic Regulation in Live, Intact Animals.

Current theories regarding tryptophan's homeostatic regulation, which are derived from in vitro, post-mortem, and cell-culture studies, lack any direct evidence supporting their occurrence in living subjects. In response, here we have used 20 s resolution, multi-hour plasma measurements to confirm, for the first time, that the cooperativity and ...

#9 [13.2] Integrated Antigen–DNA Co‐Detection Using Digital Microfluidics for Improving Diagnostic Accuracy in POCT Analysis

ABSTRACT Simultaneous detection of protein and nucleic acid (NA) provides complementary information essential for accurate analysis of complex samples. Conventional approaches for the analysis of protein and NA typically rely on separate workflows and instruments, limiting the reliability of point‐of‐care testing. Here, we present a digital micr...

#10 [13.2] Integrated Antigen–DNA Co‐Detection Using Digital Microfluidics for Improving Diagnostic Accuracy in POCT Analysis

Simultaneous detection of protein and nucleic acid (NA) provides complementary information essential for accurate analysis of complex samples. Conventional approaches for the analysis of protein and NA typically rely on separate workflows and instruments, limiting the reliability of point-of-care testing. Here, we present a digital microfluidics...

Methodology