Aptamer 学术简报 — 2026-10-09

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 206 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [21.7] Synergistic MIP-aptamer dual-recognition on silver-decorated sulfur-doped graphene quantum dots (S-GQDs@Ag) nanohybrids for ultra-sensitive impedimetric carcinoembryonic antigen detection.

The clinical utility of Carcinoembryonic Antigen (CEA) as a cornerstone biomarker for oncological monitoring is frequently hindered by the limitations of traditional immunoassays, including high costs, specialized storage requirements, and complex procedural workflows. To address these challenges, we report the development of a high-performance ...

#2 [19.3] An ultrasensitive colorimetric platform for tetracycline based on the aptamer tailoring strategy and synergistic signal amplification of Au@Ce MOF.

In this study, a rapid Au@Ce MOF-Apt functionalized three-dimensional (3D) paper platform was constructed for the detection of TC in milk. To obtain a high-affinity aptamer (Apt), based on truncation and base mutation, resulting in high-affinity G-rich sequence aptamer (Apt-M24) (27 nt, -10.4 kcal/mol). Subsequently, the Apt-M24 was efficiently ...

#3 [19.3] A bioelectrochemical aptamer sensor using vanadium-porphyrinic metal-organic framework for noninvasive hydrocortisone monitoring in sweat.

Hydrocortisone (HC) is a vital steroid hormone secreted by the adrenal cortex that regulates how the body responds to stress, the immune system and metabolism. The primary objective of this study is the fabrication of an electrochemical aptamer sensor founded on a vanadium-porphyrin metal-organic framework (V-PMOF) to detect HC. V2CTx MXene acts...

#4 [17.1] High-sensitivity simultaneous discrimination and detection of structurally similar adenosine phosphates via DNA aptamer conformational changes in α-hemolysin nanopore.

Adenosine phosphates (ATP, ADP, and AMP) play critical roles in cellular processes, yet their simultaneous detection remains challenging due to high structural similarity. To overcome this limitation, we developed a nanopore-aptamer sensing platform capable of tracking single-molecule binding dynamics in real time. This method leverages the spec...

#5 [17.1] Multiplexed electrochemical aptasensor on a nanoporous electrode: towards sensitive and anti-fouling detection of procaine, ATP and adenosine in biofluids.

This study presents a green and simple one-step electrochemical strategy for preparing nanoporous gold electrodes. The method involves anodizing the gold electrode by linear sweep voltammetry (LSV) in an aqueous solution of l-ascorbic acid (AA) and hydrochloric acid (HCl). The gold electrodes were etched in solution by hydrochloric acid to gener...

#6 [16.9] Online aptamer-based solid-phase extraction coupled with high-performance liquid chromatography-mass spectrometry for the determination of Alzheimer's disease biomarkers.

BACKGROUND: Reliable quantification of amyloid-β (Aβ) peptides in biological fluids is of major clinical and research interest in Alzheimer disease context. Conventional offline extraction approaches often involve labor-intensive manual steps and high solvent consumption, limiting throughput routine applications, reproducibility, and sustainabil...

#7 [14.6] dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

ABSTRACT Double‐stranded RNA (dsRNA) is recognized by cellular receptors as a sign of viral infection, triggering the innate immune response. Cellular dysregulation can also lead to accumulation of endogenously produced dsRNA that stimulates a viral‐like immune response. Additionally, dsRNA contamination in RNA therapeutics can lead to harmful s...

#8 [14.6] dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

ABSTRACT Double‐stranded RNA (dsRNA) is recognized by cellular receptors as a sign of viral infection, triggering the innate immune response. Cellular dysregulation can also lead to accumulation of endogenously produced dsRNA that stimulates a viral‐like immune response. Additionally, dsRNA contamination in RNA therapeutics can lead to harmful s...

#9 [14.0] Topology-enforced synthesis of atomically precise silver nanoclusters in 3D DNA lattices

DNA nanotechnology leverages the molecular design resolution of the DNA double helix to fold and tile matter into designer architectures. Recent advances in bioinorganic chemistry have exploited DNA/Ag + affinity to carry out the templated reduction of silver nanoclusters. Here, we develop a unified method that leverages the topology of DNA tria...

#10 [13.9] Acid-Activatable Rolling Circle Replication-Based Nucleic Acid Nano-Prodrug for Combined Gene Therapy of Pancreatic Cancer.

Nucleic acid-based gene therapeutics hold great potential for precisely treating pancreatic ductal adenocarcinoma (PDAC), yet their clinical translation remains challenged by the lack of efficient delivery platforms capable of simultaneously minimizing payload leakage, intrinsic toxicity, and immunogenicity. Herein, we report an acid-activatable...

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